Adam7 a disintegrin and metallopeptidase domain 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adam7provided by MGI
Official Full Name: a disintegrin and metallopeptidase domain 7provided by MGI
Primary source: MGI:MGI:107247
See related: Ensembl:ENSMUSG00000022056 AllianceGenome:MGI:107247
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EAP1; EAPI; ADAM 7
Summary: This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. This gene is specifically expressed in epididymis where the encoded protein is transferred to the sperm surface during epididymal transit. This gene is located adjacent to a related gene from the ADAM family of proteins on chromosome 14. [provided by RefSeq, Oct 2015]
Expression: Restricted expression toward genital fat pad adult (RPKM 292.3) See more
Orthologs: human all
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Genomic context

Location:: 14; 14 D1

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (68734785..68771138, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (68497336..68533689, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ADAM7 is required for normal fertility and is important for the maintenance of epididymal integrity and for sperm morphology
Title: Reduced Fertility and Altered Epididymal and Sperm Integrity in Mice Lacking ADAM7.
Suggest that Adam7 functions in fertilization through the formation of a complex with heat shock protein 5, calnexin and Itm2b during capacitation in sperm.
Title: Identification of heat shock protein 5, calnexin and integral membrane protein 2B as Adam7-interacting membrane proteins in mouse sperm.
This study provides new information regarding the unique mode of secretion and interaction of ADAM7 during the epididymis-to-sperm transfer process.
Title: ADAM7 is associated with epididymosomes and integrated into sperm plasma membrane.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the Adam7 gene: The Adam7 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, and rat.
Orthologs from Annotation Pipeline: 199 organisms have orthologs with human gene Adam7
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: disintegrin and metalloproteinase domain-containing protein 7

Names: a disintegrin and metalloprotease domain (ADAM) 7; epididymal apical protein I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007402.2 → NP_031428.2 disintegrin and metalloproteinase domain-containing protein 7 preproprotein

See identical proteins and their annotated locations for NP_031428.2

Status: REVIEWED

Source sequence(s)

AC154706, AF013107, AK136692

Consensus CDS

CCDS27234.1

UniProtKB/Swiss-Prot

F8VQC6, O35227

Related

ENSMUSP00000022640.8, ENSMUST00000022640.8

Conserved Domains (6) summary

smart00608
Location:486 → 623

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:199 → 391

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam00200
Location:410 → 482

Disintegrin; Disintegrin

pfam01421
Location:199 → 393

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:63 → 153

Pep_M12B_propep; Reprolysin family propeptide

cl14106
Location:655 → 698

Rifin_STEVOR; Rifin/stevor family