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ZNF618 zinc finger protein 618 [ Homo sapiens (human) ]

Gene ID: 114991, updated on 9-Sep-2025
Official Symbol
ZNF618provided by HGNC
Official Full Name
zinc finger protein 618provided by HGNC
Primary source
HGNC:HGNC:29416
See related
Ensembl:ENSG00000157657 MIM:617077; AllianceGenome:HGNC:29416
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NEDD10; FP13169
Summary
Enables identical protein binding activity and transcription coregulator binding activity. Predicted to be involved in regulation of DNA-templated transcription. Located in pericentric heterochromatin. [provided by Alliance of Genome Resources, Apr 2025]
Expression
Ubiquitous expression in ovary (RPKM 1.9), kidney (RPKM 1.8) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table
See ZNF618 in Genome Data Viewer
Location:
9q32
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (113876309..114056593)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (126074898..126255263)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (116638589..116818873)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene KIAA1586 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28854 Neighboring gene PDCD2 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:116636012-116636512 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:116636513-116637013 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:116697421-116697921 Neighboring gene VISTA enhancer hs641 Neighboring gene Sharpr-MPRA regulatory region 15709 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:116751538-116752038 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:116768395-116768894 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:116770304-116770804 Neighboring gene uncharacterized LOC107987120 Neighboring gene alpha-1-microglobulin/bikunin precursor

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Zinc Finger Protein 618 Regulates the Function of UHRF2 (Ubiquitin-like with PHD and Ring Finger Domains 2) as a Specific 5-Hydroxymethylcytosine Reader. Liu Y, et al. J Biol Chem, 2016 Jun 24. PMID 27129234, Free PMC Article
  2. Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate. Letra A, et al. Am J Med Genet A, 2010 Jul. PMID 20583170, Free PMC Article
  3. Association of gene polymorphisms with chronic kidney disease in Japanese individuals. Yoshida T, et al. Int J Mol Med, 2009 Oct. PMID 19724895
  4. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. Nagase T, et al. DNA Res, 2001 Dec 31. PMID 11853319
  5. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. Oguri M, et al. Am J Hypertens, 2010 Jan. PMID 19851296

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. study suggests that ZNF618 is a key protein that regulates UHRF2 function as a specific 5hmC reader in vivo.
    Title: Zinc Finger Protein 618 Regulates the Function of UHRF2 (Ubiquitin-like with PHD and Ring Finger Domains 2) as a Specific 5-Hydroxymethylcytosine Reader.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin-protein adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coregulator binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in pericentric heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
zinc finger protein 618
Names
neural precursor cell expressed, developmentally down-regulated 10

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318040.2 → NP_001304969.1  zinc finger protein 618 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which is longer than isoform 1.
    Source sequence(s)
    AJ420454, AL137850, BC036039, BC136287
    Consensus CDS
    CCDS83403.1
    UniProtKB/Swiss-Prot
    Q5T7W0
    Related
    ENSP00000483198.1, ENST00000615615.4
    Conserved Domains (2) summary
    pfam09595
    Location:250 → 358
    Metaviral_G; Metaviral_G glycoprotein
    sd00017
    Location:117 → 137
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001318041.2 → NP_001304970.1  zinc finger protein 618 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 3, which is longer than isoform 1.
    Source sequence(s)
    AJ420454, AL137850, BC036039, BC143826
    UniProtKB/Swiss-Prot
    Q5T7W0
    Related
    ENSP00000571637.1, ENST00000901578.1
    Conserved Domains (2) summary
    pfam09595
    Location:250 → 359
    Metaviral_G; Metaviral_G glycoprotein
    sd00017
    Location:117 → 137
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_001318042.2 → NP_001304971.1  zinc finger protein 618 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 4, which is longer than isoform 1.
    Source sequence(s)
    AJ420454, AL137850, BC036039
    Consensus CDS
    CCDS83402.1
    UniProtKB/Swiss-Prot
    B9EG82, Q4G0X6, Q5T7W0, Q5T7W1, Q6ZT53, Q7Z6B9, Q8TF49, Q96E49
    Related
    ENSP00000363241.5, ENST00000374126.10
    Conserved Domains (2) summary
    pfam09595
    Location:282 → 391
    Metaviral_G; Metaviral_G glycoprotein
    sd00017
    Location:149 → 169
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. NM_133374.3 → NP_588615.2  zinc finger protein 618 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the shortest isoform (1).
    Source sequence(s)
    AJ420454, AL137850, BC053892, BI463128
    Consensus CDS
    CCDS48008.1
    UniProtKB/Swiss-Prot
    Q5T7W0
    Related
    ENSP00000288466.7, ENST00000288466.11
    Conserved Domains (2) summary
    COG5189
    Location:107 → 175
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:117 → 137
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    113876309..114056593
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005251692.4 → XP_005251749.1  zinc finger protein 618 isoform X1

    Conserved Domains (1) summary
    sd00017
    Location:149 → 169
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_017014242.3 → XP_016869731.1  zinc finger protein 618 isoform X4

    Related
    ENSP00000638462.1, ENST00000968403.1

  3. XM_017014241.3 → XP_016869730.1  zinc finger protein 618 isoform X2

    Related
    ENSP00000638468.1, ENST00000968409.1

  4. XM_017014243.3 → XP_016869732.1  zinc finger protein 618 isoform X5

    Related
    ENSP00000638460.1, ENST00000968401.1

  5. XM_017014248.3 → XP_016869737.1  zinc finger protein 618 isoform X26

  6. XM_047422732.1 → XP_047278688.1  zinc finger protein 618 isoform X29

    Related
    ENSP00000638465.1, ENST00000968406.1

  7. XM_017014249.3 → XP_016869738.1  zinc finger protein 618 isoform X27

  8. XM_017014250.3 → XP_016869739.1  zinc finger protein 618 isoform X30

    Related
    ENSP00000571643.1, ENST00000901584.1

  9. XM_011518201.3 → XP_011516503.1  zinc finger protein 618 isoform X6

    Related
    ENSP00000571659.1, ENST00000901600.1
    Conserved Domains (1) summary
    sd00017
    Location:149 → 169
    ZF_C2H2; C2H2 Zn finger [structural motif]

  10. XM_047422717.1 → XP_047278673.1  zinc finger protein 618 isoform X7

    Related
    ENSP00000571652.1, ENST00000901593.1

  11. XM_017014244.3 → XP_016869733.1  zinc finger protein 618 isoform X13

    Related
    ENSP00000571651.1, ENST00000901592.1

  12. XM_017014252.3 → XP_016869741.1  zinc finger protein 618 isoform X34

    Related
    ENSP00000571650.1, ENST00000901591.1
    Conserved Domains (1) summary
    sd00017
    Location:149 → 169
    ZF_C2H2; C2H2 Zn finger [structural motif]

  13. XM_047422733.1 → XP_047278689.1  zinc finger protein 618 isoform X31

  14. XM_005251699.4 → XP_005251756.1  zinc finger protein 618 isoform X35

    Related
    ENSP00000571638.1, ENST00000901579.1
    Conserved Domains (1) summary
    sd00017
    Location:149 → 169
    ZF_C2H2; C2H2 Zn finger [structural motif]

  15. XM_011518200.3 → XP_011516502.1  zinc finger protein 618 isoform X3

    Conserved Domains (1) summary
    sd00017
    Location:149 → 169
    ZF_C2H2; C2H2 Zn finger [structural motif]

  16. XM_047422718.1 → XP_047278674.1  zinc finger protein 618 isoform X8

  17. XM_047422719.1 → XP_047278675.1  zinc finger protein 618 isoform X9

    Related
    ENSP00000571647.1, ENST00000901588.1

  18. XM_047422731.1 → XP_047278687.1  zinc finger protein 618 isoform X28

    Related
    ENSP00000571656.1, ENST00000901597.1

  19. XM_047422720.1 → XP_047278676.1  zinc finger protein 618 isoform X11

    Related
    ENSP00000638455.1, ENST00000968396.1

  20. XM_047422723.1 → XP_047278679.1  zinc finger protein 618 isoform X16

    Related
    ENSP00000571660.1, ENST00000901601.1

  21. XM_047422738.1 → XP_047278694.1  zinc finger protein 618 isoform X38

    Related
    ENSP00000571642.1, ENST00000901583.1

  22. XM_011518203.4 → XP_011516505.1  zinc finger protein 618 isoform X10

    Conserved Domains (1) summary
    sd00017
    Location:117 → 137
    ZF_C2H2; C2H2 Zn finger [structural motif]

  23. XM_017014245.3 → XP_016869734.1  zinc finger protein 618 isoform X15

    Related
    ENSP00000571636.1, ENST00000901577.1

  24. XM_047422721.1 → XP_047278677.1  zinc finger protein 618 isoform X12

  25. XM_017014246.3 → XP_016869735.1  zinc finger protein 618 isoform X17

  26. XM_047422734.1 → XP_047278690.1  zinc finger protein 618 isoform X32

    Related
    ENSP00000571648.1, ENST00000901589.1

  27. XM_047422737.1 → XP_047278693.1  zinc finger protein 618 isoform X37

    Related
    ENSP00000571639.1, ENST00000901580.1

  28. XM_047422735.1 → XP_047278691.1  zinc finger protein 618 isoform X33

    Related
    ENSP00000571646.1, ENST00000901587.1

  29. XM_011518204.4 → XP_011516506.1  zinc finger protein 618 isoform X18

    Related
    ENSP00000638467.1, ENST00000968408.1
    Conserved Domains (1) summary
    sd00017
    Location:117 → 137
    ZF_C2H2; C2H2 Zn finger [structural motif]

  30. XM_047422724.1 → XP_047278680.1  zinc finger protein 618 isoform X19

    Related
    ENSP00000571654.1, ENST00000901595.1

  31. XM_047422739.1 → XP_047278695.1  zinc finger protein 618 isoform X39

    Related
    ENSP00000571644.1, ENST00000901585.1

  32. XM_047422745.1 → XP_047278701.1  zinc finger protein 618 isoform X45

    Related
    ENSP00000638456.1, ENST00000968397.1

  33. XM_047422740.1 → XP_047278696.1  zinc finger protein 618 isoform X40

    Related
    ENSP00000571649.1, ENST00000901590.1

  34. XM_047422746.1 → XP_047278702.1  zinc finger protein 618 isoform X46

    Related
    ENSP00000571641.1, ENST00000901582.1

  35. XM_047422722.1 → XP_047278678.1  zinc finger protein 618 isoform X14

    Related
    ENSP00000638459.1, ENST00000968400.1

  36. XM_047422725.1 → XP_047278681.1  zinc finger protein 618 isoform X20

    Related
    ENSP00000638454.1, ENST00000968395.1

  37. XM_047422726.1 → XP_047278682.1  zinc finger protein 618 isoform X21

  38. XM_047422741.1 → XP_047278697.1  zinc finger protein 618 isoform X41

    Related
    ENSP00000638453.1, ENST00000968394.1

  39. XM_047422736.1 → XP_047278692.1  zinc finger protein 618 isoform X36

    Related
    ENSP00000571655.1, ENST00000901596.1

  40. XM_047422742.1 → XP_047278698.1  zinc finger protein 618 isoform X42

    Related
    ENSP00000571653.1, ENST00000901594.1

  41. XM_047422727.1 → XP_047278683.1  zinc finger protein 618 isoform X22

    Related
    ENSP00000598242.1, ENST00000928183.1

  42. XM_047422729.1 → XP_047278685.1  zinc finger protein 618 isoform X24

    Related
    ENSP00000571645.1, ENST00000901586.1

  43. XM_047422728.1 → XP_047278684.1  zinc finger protein 618 isoform X23

    Related
    ENSP00000571662.1, ENST00000901603.1

  44. XM_047422730.1 → XP_047278686.1  zinc finger protein 618 isoform X25

    Related
    ENSP00000598241.1, ENST00000928182.1

  45. XM_047422743.1 → XP_047278699.1  zinc finger protein 618 isoform X43

    Related
    ENSP00000638470.1, ENST00000968411.1

  46. XM_047422744.1 → XP_047278700.1  zinc finger protein 618 isoform X44

    Related
    ENSP00000571657.1, ENST00000901598.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    126074898..126255263
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054361896.1 → XP_054217871.1  zinc finger protein 618 isoform X1

  2. XM_054361899.1 → XP_054217874.1  zinc finger protein 618 isoform X4

  3. XM_054361897.1 → XP_054217872.1  zinc finger protein 618 isoform X2

  4. XM_054361900.1 → XP_054217875.1  zinc finger protein 618 isoform X5

  5. XM_054361921.1 → XP_054217896.1  zinc finger protein 618 isoform X26

  6. XM_054361924.1 → XP_054217899.1  zinc finger protein 618 isoform X29

  7. XM_054361922.1 → XP_054217897.1  zinc finger protein 618 isoform X27

  8. XM_054361925.1 → XP_054217900.1  zinc finger protein 618 isoform X30

  9. XM_054361901.1 → XP_054217876.1  zinc finger protein 618 isoform X6

  10. XM_054361902.1 → XP_054217877.1  zinc finger protein 618 isoform X7

  11. XM_054361908.1 → XP_054217883.1  zinc finger protein 618 isoform X13

  12. XM_054361929.1 → XP_054217904.1  zinc finger protein 618 isoform X34

  13. XM_054361926.1 → XP_054217901.1  zinc finger protein 618 isoform X31

  14. XM_054361930.1 → XP_054217905.1  zinc finger protein 618 isoform X35

  15. XM_054361898.1 → XP_054217873.1  zinc finger protein 618 isoform X3

  16. XM_054361903.1 → XP_054217878.1  zinc finger protein 618 isoform X8

  17. XM_054361904.1 → XP_054217879.1  zinc finger protein 618 isoform X9

  18. XM_054361923.1 → XP_054217898.1  zinc finger protein 618 isoform X28

  19. XM_054361906.1 → XP_054217881.1  zinc finger protein 618 isoform X11

  20. XM_054361911.1 → XP_054217886.1  zinc finger protein 618 isoform X16

  21. XM_054361933.1 → XP_054217908.1  zinc finger protein 618 isoform X38

  22. XM_054361905.1 → XP_054217880.1  zinc finger protein 618 isoform X10

  23. XM_054361910.1 → XP_054217885.1  zinc finger protein 618 isoform X15

  24. XM_054361907.1 → XP_054217882.1  zinc finger protein 618 isoform X12

  25. XM_054361912.1 → XP_054217887.1  zinc finger protein 618 isoform X17

  26. XM_054361927.1 → XP_054217902.1  zinc finger protein 618 isoform X32

  27. XM_054361932.1 → XP_054217907.1  zinc finger protein 618 isoform X37

  28. XM_054361928.1 → XP_054217903.1  zinc finger protein 618 isoform X33

  29. XM_054361913.1 → XP_054217888.1  zinc finger protein 618 isoform X18

  30. XM_054361914.1 → XP_054217889.1  zinc finger protein 618 isoform X19

  31. XM_054361934.1 → XP_054217909.1  zinc finger protein 618 isoform X39

  32. XM_054361940.1 → XP_054217915.1  zinc finger protein 618 isoform X45

  33. XM_054361935.1 → XP_054217910.1  zinc finger protein 618 isoform X40

  34. XM_054361941.1 → XP_054217916.1  zinc finger protein 618 isoform X46

  35. XM_054361909.1 → XP_054217884.1  zinc finger protein 618 isoform X14

  36. XM_054361915.1 → XP_054217890.1  zinc finger protein 618 isoform X20

  37. XM_054361916.1 → XP_054217891.1  zinc finger protein 618 isoform X21

  38. XM_054361936.1 → XP_054217911.1  zinc finger protein 618 isoform X41

  39. XM_054361931.1 → XP_054217906.1  zinc finger protein 618 isoform X36

  40. XM_054361937.1 → XP_054217912.1  zinc finger protein 618 isoform X42

  41. XM_054361917.1 → XP_054217892.1  zinc finger protein 618 isoform X22

  42. XM_054361919.1 → XP_054217894.1  zinc finger protein 618 isoform X24

  43. XM_054361918.1 → XP_054217893.1  zinc finger protein 618 isoform X23

  44. XM_054361920.1 → XP_054217895.1  zinc finger protein 618 isoform X25

  45. XM_054361938.1 → XP_054217913.1  zinc finger protein 618 isoform X43

  46. XM_054361939.1 → XP_054217914.1  zinc finger protein 618 isoform X44

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001040063.1: Suppressed sequence

    Description
    NM_001040063.1: This RefSeq was permanently suppressed because it was primarily UTR sequence.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5T7W0.1 GenPept UniProtKB/Swiss-Prot:Q5T7W0

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