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ZNF618 zinc finger protein 618 [ Homo sapiens (human) ]

Gene ID: 114991, updated on 8-Jul-2021

Summary

Official Symbol
ZNF618provided by HGNC
Official Full Name
zinc finger protein 618provided by HGNC
Primary source
HGNC:HGNC:29416
See related
Ensembl:ENSG00000157657 MIM:617077
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NEDD10; FP13169
Expression
Ubiquitous expression in ovary (RPKM 1.9), kidney (RPKM 1.8) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF618 in Genome Data Viewer
Location:
9q32
Exon count:
20
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (113876285..114056595)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (116638589..116818873)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene KIAA1586 pseudogene Neighboring gene programmed cell death 2 pseudogene Neighboring gene VISTA enhancer hs641 Neighboring gene Sharpr-MPRA regulatory region 15709 Neighboring gene uncharacterized LOC107987120 Neighboring gene alpha-1-microglobulin/bikunin precursor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coregulator binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in positive regulation of chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in pericentric heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 618
Names
neural precursor cell expressed, developmentally down-regulated 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318040.2NP_001304969.1  zinc finger protein 618 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which is longer than isoform 1.
    Source sequence(s)
    AJ420454, AL137850, BC036039, BC136287
    Consensus CDS
    CCDS83403.1
    UniProtKB/Swiss-Prot
    Q5T7W0
    Related
    ENSP00000483198.1, ENST00000615615.4
    Conserved Domains (2) summary
    pfam09595
    Location:250358
    Metaviral_G; Metaviral_G glycoprotein
    sd00017
    Location:117137
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001318041.2NP_001304970.1  zinc finger protein 618 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 3, which is longer than isoform 1.
    Source sequence(s)
    AJ420454, AL137850, BC036039, BC143826
    UniProtKB/Swiss-Prot
    Q5T7W0
    Conserved Domains (2) summary
    pfam09595
    Location:250359
    Metaviral_G; Metaviral_G glycoprotein
    sd00017
    Location:117137
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. NM_001318042.2NP_001304971.1  zinc finger protein 618 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 4, which is longer than isoform 1.
    Source sequence(s)
    AJ420454, AL137850, BC036039
    Consensus CDS
    CCDS83402.1
    UniProtKB/Swiss-Prot
    Q5T7W0
    Related
    ENSP00000363241.5, ENST00000374126.9
    Conserved Domains (2) summary
    pfam09595
    Location:282391
    Metaviral_G; Metaviral_G glycoprotein
    sd00017
    Location:149169
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. NM_133374.3NP_588615.2  zinc finger protein 618 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the shortest isoform (1).
    Source sequence(s)
    AJ420454, AL137850, BC053892, BI463128
    Consensus CDS
    CCDS48008.1
    UniProtKB/Swiss-Prot
    Q5T7W0
    Related
    ENSP00000288466.7, ENST00000288466.11
    Conserved Domains (2) summary
    COG5189
    Location:107175
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:117137
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    113876285..114056595
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005251692.3XP_005251749.1  zinc finger protein 618 isoform X1

    Conserved Domains (1) summary
    sd00017
    Location:149169
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. XM_017014242.2XP_016869731.1  zinc finger protein 618 isoform X4

  3. XM_017014241.2XP_016869730.1  zinc finger protein 618 isoform X2

  4. XM_017014243.2XP_016869732.1  zinc finger protein 618 isoform X5

  5. XM_017014248.2XP_016869737.1  zinc finger protein 618 isoform X13

  6. XM_017014249.2XP_016869738.1  zinc finger protein 618 isoform X14

  7. XM_017014250.2XP_016869739.1  zinc finger protein 618 isoform X15

  8. XM_011518201.2XP_011516503.1  zinc finger protein 618 isoform X6

    Conserved Domains (1) summary
    sd00017
    Location:149169
    ZF_C2H2; C2H2 Zn finger [structural motif]
  9. XM_017014244.2XP_016869733.1  zinc finger protein 618 isoform X8

  10. XM_017014252.2XP_016869741.1  zinc finger protein 618 isoform X17

  11. XM_005251699.3XP_005251756.1  zinc finger protein 618 isoform X18

    Conserved Domains (1) summary
    sd00017
    Location:149169
    ZF_C2H2; C2H2 Zn finger [structural motif]
  12. XM_011518200.2XP_011516502.1  zinc finger protein 618 isoform X3

    Conserved Domains (1) summary
    sd00017
    Location:149169
    ZF_C2H2; C2H2 Zn finger [structural motif]
  13. XM_011518203.3XP_011516505.1  zinc finger protein 618 isoform X7

    Conserved Domains (1) summary
    sd00017
    Location:117137
    ZF_C2H2; C2H2 Zn finger [structural motif]
  14. XM_017014245.2XP_016869734.1  zinc finger protein 618 isoform X9

  15. XM_017014246.2XP_016869735.1  zinc finger protein 618 isoform X10

  16. XM_011518204.3XP_011516506.1  zinc finger protein 618 isoform X11

    Conserved Domains (1) summary
    sd00017
    Location:117137
    ZF_C2H2; C2H2 Zn finger [structural motif]
  17. XM_017014247.2XP_016869736.1  zinc finger protein 618 isoform X12

  18. XM_017014251.2XP_016869740.1  zinc finger protein 618 isoform X16

  19. XM_011518209.3XP_011516511.1  zinc finger protein 618 isoform X19

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001040063.1: Suppressed sequence

    Description
    NM_001040063.1: This RefSeq was permanently suppressed because it was primarily UTR sequence.
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