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VASN vasorin [ Homo sapiens (human) ]

Gene ID: 114990, updated on 21-Dec-2019

Summary

Official Symbol
VASNprovided by HGNC
Official Full Name
vasorinprovided by HGNC
Primary source
HGNC:HGNC:18517
See related
Ensembl:ENSG00000168140 MIM:608843
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLITL2
Expression
Broad expression in placenta (RPKM 16.9), kidney (RPKM 16.4) and 24 other tissues See more
Orthologs

Genomic context

See VASN in Genome Data Viewer
Location:
16p13.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (4371848..4383538)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (4421849..4433529)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene GLIS2 antisense RNA 1 Neighboring gene GLIS family zinc finger 2 Neighboring gene CORO7-PAM16 readthrough Neighboring gene presequence translocase associated motor 16 Neighboring gene coronin 7 Neighboring gene DnaJ heat shock protein family (Hsp40) member A3 Neighboring gene NmrA like redox sensor 1 Neighboring gene heme oxygenase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cadherin binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transforming growth factor beta binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transforming growth factor beta binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
lysosomal membrane HDA PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
vasorin
Names
protein slit-like 2
slit-like 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138440.3NP_612449.2  vasorin precursor

    See identical proteins and their annotated locations for NP_612449.2

    Status: VALIDATED

    Source sequence(s)
    AC012676, BC013767, BC068575
    Consensus CDS
    CCDS10514.1
    UniProtKB/Swiss-Prot
    Q6EMK4
    Related
    ENSP00000306864.3, ENST00000304735.4
    Conserved Domains (7) summary
    smart00013
    Location:2354
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:298349
    LRRCT; Leucine rich repeat C-terminal domain
    sd00033
    Location:3456
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00008
    Location:409440
    EGF; EGF-like domain
    pfam00041
    Location:466535
    fn3; Fibronectin type III domain
    pfam12799
    Location:76117
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:101158
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    4371848..4383538
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187608.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    74171..85861
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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