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Adam19 ADAM metallopeptidase domain 19 [ Mus musculus (house mouse) ]

Gene ID: 11492, updated on 3-Jun-2024

Summary

Official Symbol
Adam19provided by MGI
Official Full Name
ADAM metallopeptidase domain 19provided by MGI
Primary source
MGI:MGI:105377
See related
Ensembl:ENSMUSG00000011256 AllianceGenome:MGI:105377
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MTLNB; Mltnb; MADDAM
Summary
This gene encodes a cell surface glycoprotein and member of the ADAM (a disintegrin and metalloproteinase) family of endopeptidases. The encoded protein may play a role in the ectodomain shedding of neuregulin proteins. Homozygous knockout mice for this gene exhibit heart development defects and perinatal lethality. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that undergoes proteolytic processing to generate a mature protein product. [provided by RefSeq, Aug 2015]
Expression
Ubiquitous expression in lung adult (RPKM 11.0), limb E14.5 (RPKM 10.3) and 26 other tissues See more
Orthologs
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Genomic context

See Adam19 in Genome Data Viewer
Location:
11 B1.1; 11 27.54 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (45945329..46038174)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (46054502..46147347)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29310 Neighboring gene predicted gene 12165 Neighboring gene STARR-positive B cell enhancer ABC_E10671 Neighboring gene SFT2 domain containing 1, retrotransposed Neighboring gene STARR-seq mESC enhancer starr_29320 Neighboring gene microRNA 8100 Neighboring gene STARR-seq mESC enhancer starr_29321 Neighboring gene STARR-positive B cell enhancer ABC_E3942 Neighboring gene STARR-positive B cell enhancer ABC_E8393 Neighboring gene STARR-positive B cell enhancer ABC_E5219 Neighboring gene NIPA-like domain containing 4 Neighboring gene predicted gene, 35624 Neighboring gene microRNA 7239

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH3 domain binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metalloendopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables metalloendopeptidase activity involved in amyloid precursor protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in collagen-containing extracellular matrix HDA PubMed 
NOT located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
disintegrin and metalloproteinase domain-containing protein 19
Names
MDC beta
Mel beta
a disintegrin and metallopeptidase domain 19 (meltrin beta)
a disintegrin and metalloproteinase domain 19 (meltrin beta)
adamalysin 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291890.1NP_001278819.1  disintegrin and metalloproteinase domain-containing protein 19 isoform 2

    See identical proteins and their annotated locations for NP_001278819.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK147549, BC093480, CJ248266
    UniProtKB/TrEMBL
    Q3UH67
    Conserved Domains (5) summary
    smart00050
    Location:420480
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:482630
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:191387
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:191389
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:35142
    Pep_M12B_propep; Reprolysin family propeptide
  2. NM_001291891.1NP_001278820.1  disintegrin and metalloproteinase domain-containing protein 19 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate internal splice site, compared to variant 1. This variant represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG to encode an isoform (3) that has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL663031, BC093480, CJ248266
    Conserved Domains (3) summary
    smart00050
    Location:123183
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:185333
    ACR; ADAM Cysteine-Rich Domain
    cl00064
    Location:390
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
  3. NM_001311209.1NP_001298138.1  disintegrin and metalloproteinase domain-containing protein 19 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as meltrin beta mini) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start site compared to variant 1. The encoded isoform (4) has a shorter N-terminus and lacks the prodomain, metalloprotease and disintegrin domains, compared to isoform 1.
    Source sequence(s)
    AK147217, AL663031, CJ248266
    UniProtKB/TrEMBL
    Q80UF6
    Conserved Domains (1) summary
    smart00608
    Location:1149
    ACR; ADAM Cysteine-Rich Domain
  4. NM_009616.4NP_033746.1  disintegrin and metalloproteinase domain-containing protein 19 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_033746.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK147217, AL663031, CJ111383, CJ248266
    Consensus CDS
    CCDS24571.1
    UniProtKB/Swiss-Prot
    O35674
    UniProtKB/TrEMBL
    Q3UHT3
    Related
    ENSMUSP00000011400.8, ENSMUST00000011400.8
    Conserved Domains (5) summary
    smart00050
    Location:440500
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:502650
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:211407
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:211409
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:55162
    Pep_M12B_propep; Reprolysin family propeptide

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    45945329..46038174
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245480.2XP_030101340.1  disintegrin and metalloproteinase domain-containing protein 19 isoform X2

    Conserved Domains (3) summary
    smart00050
    Location:239299
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:301449
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:10208
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
  2. XM_036156242.1XP_036012135.1  disintegrin and metalloproteinase domain-containing protein 19 isoform X1

    Conserved Domains (4) summary
    smart00050
    Location:417477
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:479627
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:188386
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:62140
    Pep_M12B_propep; Reprolysin family propeptide