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FBXO32 F-box protein 32 [ Homo sapiens (human) ]

Gene ID: 114907, updated on 1-Jun-2020

Summary

Official Symbol
FBXO32provided by HGNC
Official Full Name
F-box protein 32provided by HGNC
Primary source
HGNC:HGNC:16731
See related
Ensembl:ENSG00000156804 MIM:606604
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Fbx32; MAFbx
Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]
Expression
Broad expression in endometrium (RPKM 28.7), heart (RPKM 22.1) and 18 other tissues See more
Orthologs

Genomic context

See FBXO32 in Genome Data Viewer
Location:
8q24.13
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (123497887..123541206, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (124510127..124553493, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375737 Neighboring gene N-terminal glutamine amidase 1 Neighboring gene RN7SK pseudogene 155 Neighboring gene kelch like family member 38

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32424, MGC33610

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular response to dexamethasone stimulus IEA
Inferred from Electronic Annotation
more info
 
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein polyubiquitination TAS
Traceable Author Statement
more info
 
protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
response to denervation involved in regulation of muscle adaptation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
Z disc IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
F-box only protein 32
Names
atrogin 1
muscle atrophy F-box protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242463.2NP_001229392.1  F-box only protein 32 isoform 3

    See identical proteins and their annotated locations for NP_001229392.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two in-frame exons in the coding region, compared to variant 1. This encodes a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AC090193, AI077844, AK125888, EF143260
    Consensus CDS
    CCDS56553.1
    UniProtKB/Swiss-Prot
    Q969P5
    Related
    ENSP00000390790.2, ENST00000443022.2
    Conserved Domains (1) summary
    pfam06881
    Location:164209
    Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A
  2. NM_058229.4NP_478136.1  F-box only protein 32 isoform 1

    See identical proteins and their annotated locations for NP_478136.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) has a longer and alternate 5' terminal sequence containing an in-frame translation start codon, as compared to variant 2. It encodes a longer isoform (1).
    Source sequence(s)
    AC090193, AI077844, AK056986, AK125888
    Consensus CDS
    CCDS6345.1
    UniProtKB/Swiss-Prot
    Q969P5
    UniProtKB/TrEMBL
    A0A024R9F3
    Related
    ENSP00000428205.1, ENST00000517956.5
    Conserved Domains (1) summary
    pfam06881
    Location:257302
    Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A
  3. NM_148177.2NP_680482.1  F-box only protein 32 isoform 2

    See identical proteins and their annotated locations for NP_680482.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has a shorter and alternate 5' terminal sequence lacking an in-frame translation start codon, as compared to variant 1. It uses a downstream in-frame translation start codon and encodes a shorter isoform (2).
    Source sequence(s)
    AC090193, AI077844, AK125888, BC024030, BC100020
    UniProtKB/TrEMBL
    I6L984, Q0VAQ6, Q498Y9
    Conserved Domains (1) summary
    pfam06881
    Location:112157
    Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    123497887..123541206 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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