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Adam15 a disintegrin and metallopeptidase domain 15 (metargidin) [ Mus musculus (house mouse) ]

Gene ID: 11490, updated on 26-Sep-2022

Summary

Official Symbol
Adam15provided by MGI
Official Full Name
a disintegrin and metallopeptidase domain 15 (metargidin)provided by MGI
Primary source
MGI:MGI:1333882
See related
Ensembl:ENSMUSG00000028041 AllianceGenome:MGI:1333882
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AD56; MDC15
Summary
This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. This gene is prominently expressed in vascular cells, the endocardium, hypertrophic cells in developing bone, and specific areas of hippocampus and cerebellum. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. Mice lacking the encoded protein have increased bone mass resulting from osteoblast proliferation, and exhibit reduced neovascularization in a mouse model for retinopathy. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing. [provided by RefSeq, May 2016]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 62.5), colon adult (RPKM 58.6) and 24 other tissues See more
Orthologs
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Genomic context

See Adam15 in Genome Data Viewer
Location:
3 F1; 3 39.07 cM
Exon count:
25
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89246947..89257589, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89339640..89350028, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34118 Neighboring gene ephrin A4 Neighboring gene DC-STAMP domain containing 1 Neighboring gene DC-STAMP domain containing 2 Neighboring gene zinc finger and BTB domain containing 7B Neighboring gene predicted gene 15417

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables metallopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metallopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cardiac epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to phorbol 13-acetate 12-myristate ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within collagen catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in immune response to tumor cell ISO
Inferred from Sequence Orthology
more info
 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of receptor binding ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cilium IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
disintegrin and metalloproteinase domain-containing protein 15
Names
a disintegrin and metalloprotease domain 15 (metargidin)
metalloprotease RGD disintegrin protein
metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037722.4NP_001032811.2  disintegrin and metalloproteinase domain-containing protein 15 isoform a preproprotein

    See identical proteins and their annotated locations for NP_001032811.2

    Status: VALIDATED

    Source sequence(s)
    AC171273
    Consensus CDS
    CCDS17502.1
    UniProtKB/Swiss-Prot
    O88839, Q9QYL2
    Related
    ENSMUSP00000029676.6, ENSMUST00000029676.12
    Conserved Domains (5) summary
    smart00050
    Location:431504
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:509650
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:214412
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:214414
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:67155
    Pep_M12B_propep; Reprolysin family propeptide
  2. NM_001409479.1NP_001396408.1  disintegrin and metalloproteinase domain-containing protein 15 isoform c preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC171273
  3. NM_001409480.1NP_001396409.1  disintegrin and metalloproteinase domain-containing protein 15 isoform d preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC171273
  4. NM_001409481.1NP_001396410.1  disintegrin and metalloproteinase domain-containing protein 15 isoform e preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC171273
  5. NM_001409482.1NP_001396411.1  disintegrin and metalloproteinase domain-containing protein 15 isoform f precursor

    Status: VALIDATED

    Source sequence(s)
    AC171273
  6. NM_001409483.1NP_001396412.1  disintegrin and metalloproteinase domain-containing protein 15 isoform g precursor

    Status: VALIDATED

    Source sequence(s)
    AC171273
  7. NM_001409484.1NP_001396413.1  disintegrin and metalloproteinase domain-containing protein 15 isoform h precursor

    Status: VALIDATED

    Source sequence(s)
    AC171273
  8. NM_001409485.1NP_001396414.1  disintegrin and metalloproteinase domain-containing protein 15 isoform i

    Status: VALIDATED

    Source sequence(s)
    AC171273
  9. NM_001409486.1NP_001396415.1  disintegrin and metalloproteinase domain-containing protein 15 isoform j precursor

    Status: VALIDATED

    Source sequence(s)
    AC171273
  10. NM_001409487.1NP_001396416.1  disintegrin and metalloproteinase domain-containing protein 15 isoform k precursor

    Status: VALIDATED

    Source sequence(s)
    AC171273
  11. NM_001409488.1NP_001396417.1  disintegrin and metalloproteinase domain-containing protein 15 isoform m

    Status: VALIDATED

    Source sequence(s)
    AC171273
  12. NM_001409489.1NP_001396418.1  disintegrin and metalloproteinase domain-containing protein 15 isoform l

    Status: VALIDATED

    Source sequence(s)
    AC171273
  13. NM_009614.4NP_033744.1  disintegrin and metalloproteinase domain-containing protein 15 isoform b precursor

    See identical proteins and their annotated locations for NP_033744.1

    Status: VALIDATED

    Source sequence(s)
    AC171273
    Consensus CDS
    CCDS17503.1
    UniProtKB/Swiss-Prot
    O88839
    Related
    ENSMUSP00000074167.7, ENSMUST00000074582.7
    Conserved Domains (5) summary
    smart00050
    Location:431504
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:509650
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:214412
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:214414
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:67155
    Pep_M12B_propep; Reprolysin family propeptide

RNA

  1. NR_176854.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC171273
  2. NR_176855.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC171273

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    89246947..89257589 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500918.3XP_006500981.1  disintegrin and metalloproteinase domain-containing protein 15 isoform X1

    UniProtKB/Swiss-Prot
    O88839
    Related
    ENSMUSP00000103072.3, ENSMUST00000107448.9
    Conserved Domains (4) summary
    smart00050
    Location:431504
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:509650
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:214412
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01562
    Location:62147
    Pep_M12B_propep; Reprolysin family propeptide

RNA

  1. XR_375482.5 RNA Sequence

  2. XR_375481.5 RNA Sequence

  3. XR_375479.5 RNA Sequence

  4. XR_375480.5 RNA Sequence