C1QTNF3 C1q and TNF related 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: C1QTNF3provided by HGNC
Official Full Name: C1q and TNF related 3provided by HGNC
Primary source: HGNC:HGNC:14326
See related: Ensembl:ENSG00000082196 MIM:612045; AllianceGenome:HGNC:14326
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CORS; CORCS; CTRP3; CORS26; C1ATNF3; CORS-26
Summary: Enables identical protein binding activity. Involved in several processes, including cellular triglyceride homeostasis; negative regulation of NIK/NF-kappaB signaling; and regulation of cytokine production. Acts upstream of or within negative regulation of gluconeogenesis. Located in extracellular exosome and membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in esophagus (RPKM 12.4), urinary bladder (RPKM 10.0) and 21 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5p13.2

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
110	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (34017858..34244724, complement)
110	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (34139780..34489333, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (34017963..34244829, complement)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CTRP3 as a novel biomarker in the plasma of Saudi children with autism.
Title: CTRP3 as a novel biomarker in the plasma of Saudi children with autism.
Exenatide increases CTRP3 gene expression in adipose cells by inhibiting adipogenesis and induces apoptosis.
Title: Exenatide increases CTRP3 gene expression in adipose cells by inhibiting adipogenesis and induces apoptosis.
C1q/tumour necrosis factor-related protein-3 alleviates high-glucose-induced lipid accumulation and necroinflammation in renal tubular cells by activating the adenosine monophosphate-activated protein kinase pathway.
Title: C1q/tumour necrosis factor-related protein-3 alleviates high-glucose-induced lipid accumulation and necroinflammation in renal tubular cells by activating the adenosine monophosphate-activated protein kinase pathway.
CTRP3 promotes TNF-alpha-induced apoptosis and barrier dysfunction in salivary epithelial cells.
Title: CTRP3 promotes TNF-α-induced apoptosis and barrier dysfunction in salivary epithelial cells.
CTRP3 alleviates myocardial ischemia/reperfusion injury in mice through activating LAMP1/JIP2/JNK pathway.
Title: CTRP3 alleviates myocardial ischemia/reperfusion injury in mice through activating LAMP1/JIP2/JNK pathway.
Plasma C1q/tumor necrosis factor-related protein-3 concentrations are associated with diabetic peripheral neuropathy.
Title: Plasma C1q/tumor necrosis factor-related protein-3 concentrations are associated with diabetic peripheral neuropathy.
Transgenic overexpression of CTRP3 does not prevent alcohol induced hepatic steatosis in female mice.
Title: Transgenic overexpression of CTRP3 does not prevent alcohol induced hepatic steatosis in female mice.
MicroRNA miR-495 regulates the development of Hepatocellular Carcinoma by targeting C1q/tumor necrosis factor-related protein-3 (CTRP3).
Title: MicroRNA miR-495 regulates the development of Hepatocellular Carcinoma by targeting C1q/tumor necrosis factor-related protein-3 (CTRP3).
Plasma miR-409-3p promotes acute cerebral infarction via suppressing CTRP3.
Title: Plasma miR-409-3p promotes acute cerebral infarction via suppressing CTRP3.
Serum levels of C1q/TNF-related protein-3 in inflammatory bowel disease patients and its inverse association with inflammatory cytokines and insulin resistance.
Title: Serum levels of C1q/TNF-related protein-3 in inflammatory bowel disease patients and its inverse association with inflammatory cytokines and insulin resistance.

Submit: New GeneRIF Correction See all GeneRIFs (55)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

G42361 (e-PCR)
- UniSTS:94220

WI-22131 (e-PCR)
- UniSTS:72304

STS-AA025644 (e-PCR)
- UniSTS:1427

GDB:335751 (e-PCR)
- UniSTS:156601

Readthrough C1QTNF3-AMACR

Readthrough gene: C1QTNF3-AMACR, Included gene: AMACR

Homology

Homologs of the C1QTNF3 gene: The C1QTNF3 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog.
Orthologs from Annotation Pipeline: 329 organisms have orthologs with human gene C1QTNF3
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables molecular_function	ND No biological Data available more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in fat cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in intracellular triglyceride homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of NIK/NF-kappaB signaling	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of gluconeogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of monocyte chemotactic protein-1 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of adiponectin secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytokine production	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of collagen trimer	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in membrane	HDA more info	PubMed

General protein information

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Preferred Names: complement C1q tumor necrosis factor-related protein 3

Names: C1q and tumor necrosis factor related protein 3; cartonectin; collagenous repeat-containing sequence 26 kDa protein; collagenous repeat-containing sequence of 26-kDa; secretory protein CORS26

NP_112207.1

EC 5.1.99.4

NP_852100.3

EC 5.1.99.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030945.4 → NP_112207.1 complement C1q tumor necrosis factor-related protein 3 isoform a precursor

See identical proteins and their annotated locations for NP_112207.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shortest transcript and encodes the shorter isoform (a).

Source sequence(s)

AC139783, AF329837, AK295968, BX640995

Consensus CDS

CCDS3904.1

UniProtKB/Swiss-Prot

Q96KY1, Q9BXJ4

Related

ENSP00000231338.7, ENST00000231338.7

Conserved Domains (2) summary

pfam01391
Location:71 → 113

Collagen; Collagen triple helix repeat (20 copies)

pfam00386
Location:119 → 242

C1q; C1q domain
NM_181435.6 → NP_852100.3 complement C1q tumor necrosis factor-related protein 3 isoform b precursor

See identical proteins and their annotated locations for NP_852100.3

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site that results in an additional segment in the 5' coding region, compared to variant 1. The encoded isoform (b) is longer than isoform a.

Source sequence(s)

AC139783, AK295968, BX640995

Consensus CDS

CCDS34141.1

UniProtKB/Swiss-Prot

Q9BXJ4

Related

ENSP00000371497.3, ENST00000382065.8

Conserved Domains (2) summary

pfam01391
Location:144 → 186

Collagen; Collagen triple helix repeat (20 copies)

pfam00386
Location:192 → 315

C1q; C1q domain

RNA

NR_146599.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses a different 5' exon structure compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.

Source sequence(s)

AC138409, AC139783, AC139792