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C1QTNF3 C1q and TNF related 3 [ Homo sapiens (human) ]

Gene ID: 114899, updated on 19-Jul-2021

Summary

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Official Symbol
C1QTNF3provided by HGNC
Official Full Name
C1q and TNF related 3provided by HGNC
Primary source
HGNC:HGNC:14326
See related
Ensembl:ENSG00000082196 MIM:612045
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CORS; CORCS; CTRP3; CORS26; C1ATNF3; CORS-26
Expression
Broad expression in esophagus (RPKM 12.4), urinary bladder (RPKM 10.0) and 21 other tissues See more
Orthologs
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Genomic context

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See C1QTNF3 in Genome Data Viewer
Location:
5p13.2
Exon count:
13
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (34017858..34244724, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (34017963..34244829, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 45 member 2 Neighboring gene C1QTNF3-AMACR readthrough (NMD candidate) Neighboring gene proteasome 26S subunit, ATPase, 6 pseudogene 3 Neighboring gene alpha-methylacyl-CoA racemase Neighboring gene GUSB pseudogene 18 Neighboring gene integral membrane glycoprotein-like pseudogene Neighboring gene uncharacterized LOC105374719 Neighboring gene UBX domain protein 2A pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. CTRP3 and serum triglycerides in children aged 7-10 years. Alamian A, et al. PLoS One, 2020. PMID 33270666, Free PMC Article
  2. Downregulation of CTRP-3 by Weight Loss In Vivo and by Bile Acids and Incretins in Adipocytes In Vitro. Schmid A, et al. Int J Mol Sci, 2020 Oct 31. PMID 33142914, Free PMC Article
  3. CTRP3 Activates the AMPK/SIRT1-PGC-1α Pathway to Protect Mitochondrial Biogenesis and Functions in Cerebral Ischemic Stroke. Gao J, et al. Neurochem Res, 2020 Dec. PMID 33098065
  4. CTRP3 inhibits high glucose-induced oxidative stress and apoptosis in retinal pigment epithelial cells. Zhang J, et al. Artif Cells Nanomed Biotechnol, 2019 Dec. PMID 31556307
  5. CTRP3 Protects against High Glucose-Induced Cell Injury in Human Umbilical Vein Endothelial Cells. Wang F, et al. Anal Cell Pathol (Amst), 2019. PMID 31428552, Free PMC Article

See all (57) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CTRP3 Activates the AMPK/SIRT1-PGC-1alpha Pathway to Protect Mitochondrial Biogenesis and Functions in Cerebral Ischemic Stroke.
    Title: CTRP3 Activates the AMPK/SIRT1-PGC-1α Pathway to Protect Mitochondrial Biogenesis and Functions in Cerebral Ischemic Stroke.
  2. Up-regulating lncRNA OIP5-AS1 protects neuron injury against cerebral hypoxia-ischemia induced inflammation and oxidative stress in microglia/macrophage through activating CTRP3 via sponging miR-186-5p.
    Title: Up-regulating lncRNA OIP5-AS1 protects neuron injury against cerebral hypoxia-ischemia induced inflammation and oxidative stress in microglia/macrophage through activating CTRP3 via sponging miR-186-5p.
  3. Downregulation of CTRP-3 by Weight Loss In Vivo and by Bile Acids and Incretins in Adipocytes In Vitro.
    Title: Downregulation of CTRP-3 by Weight Loss In Vivo and by Bile Acids and Incretins in Adipocytes In Vitro.
  4. CTRP3 and serum triglycerides in children aged 7-10 years.
    Title: CTRP3 and serum triglycerides in children aged 7-10 years.
  5. CTRP3 could improve renal fibrosis, to some extent, through inhibiting the Notch pathway.
    Title: C1q/tumor necrosis factor-related protein-3 improves renal fibrosis via inhibiting notch signaling pathways.
  6. CTRP3 treatment blocked the accumulation of inflammatory factors and cell loss in Human Umbilical Vein Endothelial Cells after high glucose exposure.
    Title: CTRP3 Protects against High Glucose-Induced Cell Injury in Human Umbilical Vein Endothelial Cells.
  7. CTRP3 and CTRP9 are decreased in patients with heart failure with reduced ejection fraction, proportionate to disease severity, and each is associated with increased morbidity and mortality.
    Title: C1q/TNF-related protein 3 (CTRP3) and 9 (CTRP9) concentrations are decreased in patients with heart failure and are associated with increased morbidity and mortality.
  8. CTRP3 attenuated HG-stimulated oxidative stress and apoptosis in ARPE-19 cells
    Title: CTRP3 inhibits high glucose-induced oxidative stress and apoptosis in retinal pigment epithelial cells.
  9. Serum levels of C1q TNF related protein 3 (CTRP3) were significantly lower in patients with type 2 diabetes mellitus (T2DM) and T2DM-diabetic nephropathy (NP) compared to controls.
    Title: Serum levels of CTRP3 in diabetic nephropathy and its relationship with insulin resistance and kidney function.
  10. With the increase of FPG, the progression of GDM IR (gestational diabetes mellitus insulin resistance) patients is increased, and pancreatic beta-cell function progressively declines. The decrease of CTRP3 level in fasting serum in GDM patients plays a metabolic role in the pathogenesis of GDM
    Title: Expression of C1q/TNF-related protein-3 (CTRP3) in serum of patients with gestational diabetes mellitus and its relationship with insulin resistance.
Submit: New GeneRIF Correction See all GeneRIFs (43)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Readthrough C1QTNF3-AMACR

Readthrough gene: C1QTNF3-AMACR, Included gene: AMACR

Homology

Clone Names

  • FLJ37576

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular triglyceride homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fat cell differentiation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of NIK/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of gluconeogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of inflammatory response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of monocyte chemotactic protein-1 production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of adiponectin secretion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cytokine production IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular exosome HDA PubMed 
located_in membrane HDA PubMed 

General protein information

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Preferred Names
complement C1q tumor necrosis factor-related protein 3
Names
C1q and tumor necrosis factor related protein 3
cartonectin
collagenous repeat-containing sequence 26 kDa protein
collagenous repeat-containing sequence of 26-kDa
secretory protein CORS26
NP_112207.1
NP_852100.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030945.4 → NP_112207.1  complement C1q tumor necrosis factor-related protein 3 isoform a precursor

    See identical proteins and their annotated locations for NP_112207.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the shorter isoform (a).
    Source sequence(s)
    AC139783, AF329837, AK295968, BX640995
    Consensus CDS
    CCDS3904.1
    UniProtKB/Swiss-Prot
    Q9BXJ4
    Related
    ENSP00000231338.7, ENST00000231338.7
    Conserved Domains (2) summary
    pfam01391
    Location:71 → 113
    Collagen; Collagen triple helix repeat (20 copies)
    pfam00386
    Location:119 → 242
    C1q; C1q domain

  2. NM_181435.6 → NP_852100.3  complement C1q tumor necrosis factor-related protein 3 isoform b precursor

    See identical proteins and their annotated locations for NP_852100.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site that results in an additional segment in the 5' coding region, compared to variant 1. The encoded isoform (b) is longer than isoform a.
    Source sequence(s)
    AC139783, AK295968, BX640995
    Consensus CDS
    CCDS34141.1
    UniProtKB/Swiss-Prot
    Q9BXJ4
    Related
    ENSP00000371497.3, ENST00000382065.8
    Conserved Domains (2) summary
    pfam01391
    Location:144 → 186
    Collagen; Collagen triple helix repeat (20 copies)
    pfam00386
    Location:192 → 315
    C1q; C1q domain

RNA

  1. NR_146599.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses a different 5' exon structure compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AC138409, AC139783, AC139792

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    34017858..34244724 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BXJ4.1 GenPept UniProtKB/Swiss-Prot:Q9BXJ4

Gene LinkOut

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