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C1QTNF3 C1q and TNF related 3 [ Homo sapiens (human) ]

Gene ID: 114899, updated on 11-Jun-2025
Official Symbol
C1QTNF3provided by HGNC
Official Full Name
C1q and TNF related 3provided by HGNC
Primary source
HGNC:HGNC:14326
See related
Ensembl:ENSG00000082196 MIM:612045; AllianceGenome:HGNC:14326
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CORS; CORCS; CTRP3; CORS26; C1ATNF3; CORS-26
Summary
Enables identical protein binding activity. Involved in several processes, including intracellular triglyceride homeostasis; negative regulation of non-canonical NF-kappaB signal transduction; and regulation of cytokine production. Acts upstream of or within negative regulation of gluconeogenesis. Located in extracellular exosome and membrane. [provided by Alliance of Genome Resources, Jun 2025]
Expression
Broad expression in esophagus (RPKM 12.4), urinary bladder (RPKM 10.0) and 21 other tissues See more
Orthologs
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See C1QTNF3 in Genome Data Viewer
Location:
5p13.2
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (34017858..34244724, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (34139780..34489333, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (34017963..34244829, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 45 member 2 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:33978101-33978993 Neighboring gene C1QTNF3-AMACR readthrough (NMD candidate) Neighboring gene proteasome 26S subunit, ATPase, 6 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15964 Neighboring gene alpha-methylacyl-CoA racemase Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:34179672-34180662 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:34182107-34182256 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:34182743-34183352 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:34188477-34188645 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22457 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:34190819-34191799 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:34191800-34192781 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:34192782-34193762 Neighboring gene GUSB pseudogene 18 Neighboring gene integral membrane glycoprotein-like pseudogene Neighboring gene Sharpr-MPRA regulatory region 11513 Neighboring gene uncharacterized LOC105374719 Neighboring gene uncharacterized LOC124900957

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. RankProd Combined with Genetic Algorithm Optimized Artificial Neural Network Establishes a Diagnostic and Prognostic Prediction Model that Revealed C1QTNF3 as a Biomarker for Prostate Cancer. Hou Q, et al. EBioMedicine, 2018 Jun. PMID 29861410, Free PMC Article
  2. CTRP3 Activates the AMPK/SIRT1-PGC-1α Pathway to Protect Mitochondrial Biogenesis and Functions in Cerebral Ischemic Stroke. Gao J, et al. Neurochem Res, 2020 Dec. PMID 33098065
  3. Serum levels of C1q/TNF-related protein-3 in inflammatory bowel disease patients and its inverse association with inflammatory cytokines and insulin resistance. Mohamadinarab M, et al. IUBMB Life, 2020 Aug. PMID 32311832
  4. CTRP3 inhibits high glucose-induced oxidative stress and apoptosis in retinal pigment epithelial cells. Zhang J, et al. Artif Cells Nanomed Biotechnol, 2019 Dec. PMID 31556307
  5. CTRP3 Protects against High Glucose-Induced Cell Injury in Human Umbilical Vein Endothelial Cells. Wang F, et al. Anal Cell Pathol (Amst), 2019. PMID 31428552, Free PMC Article

See all (79) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The relationships between biological novel biomarkers Lp-PLA2 and CTRP-3 and CVD in patients with type 2 diabetes mellitus.
    Title: The relationships between biological novel biomarkers Lp-PLA(2) and CTRP-3 and CVD in patients with type 2 diabetes mellitus.
  2. Decreased circulating CTRP3 levels in acute and chronic cardiovascular patients.
    Title: Decreased circulating CTRP3 levels in acute and chronic cardiovascular patients.
  3. Clinical Significance of Serum CTRP3 Level in the Prediction of Cardiac and Intestinal Mucosal Barrier Dysfunction in Patients with Severe Acute Pancreatitis.
    Title: Clinical Significance of Serum CTRP3 Level in the Prediction of Cardiac and Intestinal Mucosal Barrier Dysfunction in Patients with Severe Acute Pancreatitis.
  4. FOXO6 transcription inhibition of CTRP3 promotes OGD/R-triggered cardiac microvascular endothelial barrier disruption via SIRT1/Nrf2 signalling.
    Title: FOXO6 transcription inhibition of CTRP3 promotes OGD/R-triggered cardiac microvascular endothelial barrier disruption via SIRT1/Nrf2 signalling.
  5. CTRP3 attenuates inflammation, oxidative and cell death in cisplatin induced HK-2 cells.
    Title: CTRP3 attenuates inflammation, oxidative and cell death in cisplatin induced HK-2 cells.
  6. KLF10 knockdown negatively regulates CTRP3 to improve OGD/R-induced brain microvascular endothelial cell injury and barrier dysfunction through Nrf2/HO-1 signaling pathway.
    Title: KLF10 knockdown negatively regulates CTRP3 to improve OGD/R-induced brain microvascular endothelial cell injury and barrier dysfunction through Nrf2/HO-1 signaling pathway.
  7. Clinical Diagnostic Values of C1q/TNF-Related Protein-3 for Polycystic Ovary Syndrome Women with Insulin Resistance.
    Title: Clinical Diagnostic Values of C1q/TNF-Related Protein-3 for Polycystic Ovary Syndrome Women with Insulin Resistance.
  8. Adipokine C1q/Tumor Necrosis Factor- Related Protein 3 (CTRP3) Attenuates Intestinal Inflammation Via Sirtuin 1/NF-kappaB Signaling.
    Title: Adipokine C1q/Tumor Necrosis Factor- Related Protein 3 (CTRP3) Attenuates Intestinal Inflammation Via Sirtuin 1/NF-κB Signaling.
  9. CTRP3 as a novel biomarker in the plasma of Saudi children with autism.
    Title: CTRP3 as a novel biomarker in the plasma of Saudi children with autism.
  10. Exenatide increases CTRP3 gene expression in adipose cells by inhibiting adipogenesis and induces apoptosis.
    Title: Exenatide increases CTRP3 gene expression in adipose cells by inhibiting adipogenesis and induces apoptosis.
Submit: New GeneRIF Correction See all GeneRIFs (63)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Readthrough C1QTNF3-AMACR

Readthrough gene: C1QTNF3-AMACR, Included gene: AMACR

Homology

Clone Names

  • FLJ37576

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chemical homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in fat cell differentiation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in intracellular triglyceride homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of gluconeogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of gluconeogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of gluconeogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of inflammatory response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of monocyte chemotactic protein-1 production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of non-canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of adiponectin secretion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of adiponectin secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cytokine production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cytokine production IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular exosome HDA PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane HDA PubMed 
Preferred Names
complement C1q tumor necrosis factor-related protein 3
Names
C1q and tumor necrosis factor related protein 3
cartonectin
collagenous repeat-containing sequence 26 kDa protein
collagenous repeat-containing sequence of 26-kDa
secretory protein CORS26
NP_112207.1
NP_852100.3

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030945.4 → NP_112207.1  complement C1q tumor necrosis factor-related protein 3 isoform a precursor

    See identical proteins and their annotated locations for NP_112207.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the shorter isoform (a).
    Source sequence(s)
    AC139783, AF329837, AK295968, BX640995
    Consensus CDS
    CCDS3904.1
    UniProtKB/Swiss-Prot
    Q0VAN4, Q542Y2, Q6MZN1, Q96KY1, Q9BXJ4
    Related
    ENSP00000231338.7, ENST00000231338.7
    Conserved Domains (2) summary
    pfam01391
    Location:71 → 113
    Collagen; Collagen triple helix repeat (20 copies)
    pfam00386
    Location:119 → 242
    C1q; C1q domain

  2. NM_181435.6 → NP_852100.3  complement C1q tumor necrosis factor-related protein 3 isoform b precursor

    See identical proteins and their annotated locations for NP_852100.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site that results in an additional segment in the 5' coding region, compared to variant 1. The encoded isoform (b) is longer than isoform a.
    Source sequence(s)
    AC139783, AK295968, BX640995
    Consensus CDS
    CCDS34141.1
    UniProtKB/Swiss-Prot
    Q9BXJ4
    Related
    ENSP00000371497.3, ENST00000382065.8
    Conserved Domains (2) summary
    pfam01391
    Location:144 → 186
    Collagen; Collagen triple helix repeat (20 copies)
    pfam00386
    Location:192 → 315
    C1q; C1q domain

RNA

  1. NR_146599.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses a different 5' exon structure compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AC138409, AC139783, AC139792

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    34017858..34244724 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    34139780..34489333 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BXJ4.1 GenPept UniProtKB/Swiss-Prot:Q9BXJ4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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