C1QTNF3 C1q and TNF related 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: C1QTNF3provided by HGNC
Official Full Name: C1q and TNF related 3provided by HGNC
Primary source: HGNC:HGNC:14326
See related: Ensembl:ENSG00000082196 MIM:612045
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CORS; CORCS; CTRP3; CORS26; C1ATNF3; CORS-26
Expression: Broad expression in esophagus (RPKM 12.4), urinary bladder (RPKM 10.0) and 21 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5p13.2

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
109.20210514	current	GRCh38.p13 (GCF_000001405.39)	5	NC_000005.10 (34017858..34244724, complement)
105.20201022	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (34017963..34244829, complement)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Association of Plasma C1q/TNF-Related Protein 3 (CTRP3) in Patients with Atrial Fibrillation.
Title: Association of Plasma C1q/TNF-Related Protein 3 (CTRP3) in Patients with Atrial Fibrillation.
CTRP3 Activates the AMPK/SIRT1-PGC-1alpha Pathway to Protect Mitochondrial Biogenesis and Functions in Cerebral Ischemic Stroke.
Title: CTRP3 Activates the AMPK/SIRT1-PGC-1α Pathway to Protect Mitochondrial Biogenesis and Functions in Cerebral Ischemic Stroke.
Up-regulating lncRNA OIP5-AS1 protects neuron injury against cerebral hypoxia-ischemia induced inflammation and oxidative stress in microglia/macrophage through activating CTRP3 via sponging miR-186-5p.
Title: Up-regulating lncRNA OIP5-AS1 protects neuron injury against cerebral hypoxia-ischemia induced inflammation and oxidative stress in microglia/macrophage through activating CTRP3 via sponging miR-186-5p.
Downregulation of CTRP-3 by Weight Loss In Vivo and by Bile Acids and Incretins in Adipocytes In Vitro.
Title: Downregulation of CTRP-3 by Weight Loss In Vivo and by Bile Acids and Incretins in Adipocytes In Vitro.
CTRP3 and serum triglycerides in children aged 7-10 years.
Title: CTRP3 and serum triglycerides in children aged 7-10 years.
CTRP3 could improve renal fibrosis, to some extent, through inhibiting the Notch pathway.
Title: C1q/tumor necrosis factor-related protein-3 improves renal fibrosis via inhibiting notch signaling pathways.
CTRP3 treatment blocked the accumulation of inflammatory factors and cell loss in Human Umbilical Vein Endothelial Cells after high glucose exposure.
Title: CTRP3 Protects against High Glucose-Induced Cell Injury in Human Umbilical Vein Endothelial Cells.
CTRP3 and CTRP9 are decreased in patients with heart failure with reduced ejection fraction, proportionate to disease severity, and each is associated with increased morbidity and mortality.
Title: C1q/TNF-related protein 3 (CTRP3) and 9 (CTRP9) concentrations are decreased in patients with heart failure and are associated with increased morbidity and mortality.
CTRP3 attenuated HG-stimulated oxidative stress and apoptosis in ARPE-19 cells
Title: CTRP3 inhibits high glucose-induced oxidative stress and apoptosis in retinal pigment epithelial cells.
Serum levels of C1q TNF related protein 3 (CTRP3) were significantly lower in patients with type 2 diabetes mellitus (T2DM) and T2DM-diabetic nephropathy (NP) compared to controls.
Title: Serum levels of CTRP3 in diabetic nephropathy and its relationship with insulin resistance and kidney function.

Submit: New GeneRIF Correction See all GeneRIFs (44)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

G42361 (e-PCR)
- UniSTS:94220

WI-22131 (e-PCR)
- UniSTS:72304

STS-AA025644 (e-PCR)
- UniSTS:1427

GDB:335751 (e-PCR)
- UniSTS:156601

Readthrough C1QTNF3-AMACR

Readthrough gene: C1QTNF3-AMACR, Included gene: AMACR

Homology

Homologs of the C1QTNF3 gene: The C1QTNF3 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog.
Orthologs from Annotation Pipeline: 290 organisms have orthologs with human gene C1QTNF3
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables molecular_function	ND No biological Data available more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular triglyceride homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in fat cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of NIK/NF-kappaB signaling	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of gluconeogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of monocyte chemotactic protein-1 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of adiponectin secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytokine production	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of collagen trimer	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	HDA more info	PubMed
located_in membrane	HDA more info	PubMed

General protein information

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Preferred Names: complement C1q tumor necrosis factor-related protein 3

Names: C1q and tumor necrosis factor related protein 3; cartonectin; collagenous repeat-containing sequence 26 kDa protein; collagenous repeat-containing sequence of 26-kDa; secretory protein CORS26

NP_112207.1

EC 5.1.99.4

NP_852100.3

EC 5.1.99.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030945.4 → NP_112207.1 complement C1q tumor necrosis factor-related protein 3 isoform a precursor

See identical proteins and their annotated locations for NP_112207.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shortest transcript and encodes the shorter isoform (a).

Source sequence(s)

AC139783, AF329837, AK295968, BX640995

Consensus CDS

CCDS3904.1

UniProtKB/Swiss-Prot

Q9BXJ4

Related

ENSP00000231338.7, ENST00000231338.7

Conserved Domains (2) summary

pfam01391
Location:71 → 113

Collagen; Collagen triple helix repeat (20 copies)

pfam00386
Location:119 → 242

C1q; C1q domain
NM_181435.6 → NP_852100.3 complement C1q tumor necrosis factor-related protein 3 isoform b precursor

See identical proteins and their annotated locations for NP_852100.3

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site that results in an additional segment in the 5' coding region, compared to variant 1. The encoded isoform (b) is longer than isoform a.

Source sequence(s)

AC139783, AK295968, BX640995

Consensus CDS

CCDS34141.1

UniProtKB/Swiss-Prot

Q9BXJ4

Related

ENSP00000371497.3, ENST00000382065.8

Conserved Domains (2) summary

pfam01391
Location:144 → 186

Collagen; Collagen triple helix repeat (20 copies)

pfam00386
Location:192 → 315

C1q; C1q domain

RNA

NR_146599.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses a different 5' exon structure compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.

Source sequence(s)

AC138409, AC139783, AC139792