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OSBPL10 oxysterol binding protein like 10 [ Homo sapiens (human) ]

Gene ID: 114884, updated on 6-May-2021

Summary

Official Symbol
OSBPL10provided by HGNC
Official Full Name
oxysterol binding protein like 10provided by HGNC
Primary source
HGNC:HGNC:16395
See related
Ensembl:ENSG00000144645 MIM:606738
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ORP10; OSBP9
Summary
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Expression
Broad expression in testis (RPKM 5.3), placenta (RPKM 5.2) and 23 other tissues See more
Orthologs
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Genomic context

See OSBPL10 in Genome Data Viewer
Location:
3p23
Exon count:
15
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (31660825..31981301, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (31702317..32022754, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377019 Neighboring gene STT3 oligosaccharyltransferase complex catalytic subunit B Neighboring gene OSBPL10 antisense RNA 1 Neighboring gene zinc finger protein 587 pseudogene 1 Neighboring gene zinc finger protein 860 Neighboring gene ribosomal protein L21 pseudogene 40

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of periodontal health measured by probing depth in adults ages 18-49 years.
GeneReviews: Not available
Identification of evidence suggestive of an association with peripheral arterial disease at the OSBPL10 locus by genome-wide investigation in the Japanese population.
GeneReviews: Not available
Is the gene-environment interaction paradigm relevant to genome-wide studies? The case of education and body mass index.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20363

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cholesterol binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cholesterol binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylserine binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sterol binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sterol transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in phosphatidylserine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
involved_in sterol transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
oxysterol-binding protein-related protein 10
Names
ORP-10
OSBP-related protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001174060.2NP_001167531.1  oxysterol-binding protein-related protein 10 isoform 2

    See identical proteins and their annotated locations for NP_001167531.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AK304067, BC003168
    Consensus CDS
    CCDS54559.1
    UniProtKB/Swiss-Prot
    Q9BXB5
    Related
    ENSP00000406124.2, ENST00000438237.6
    Conserved Domains (3) summary
    cd13291
    Location:77179
    PH_ORP10_ORP11; Human Oxysterol binding protein (OSBP) related proteins 10 and 11 (ORP10 and ORP11) Pleckstrin homology (PH) domain
    pfam00169
    Location:78171
    PH; PH domain
    pfam01237
    Location:338692
    Oxysterol_BP; Oxysterol-binding protein
  2. NM_017784.5NP_060254.2  oxysterol-binding protein-related protein 10 isoform 1

    See identical proteins and their annotated locations for NP_060254.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK000370, BC003168, DC377079
    Consensus CDS
    CCDS2651.1
    UniProtKB/Swiss-Prot
    Q9BXB5
    UniProtKB/TrEMBL
    Q9NX98
    Related
    ENSP00000379804.2, ENST00000396556.7
    Conserved Domains (3) summary
    cd13291
    Location:77183
    PH_ORP10_ORP11; Human Oxysterol binding protein (OSBP) related proteins 10 and 11 (ORP10 and ORP11) Pleckstrin homology (PH) domain
    pfam00169
    Location:78171
    PH; PH domain
    pfam01237
    Location:402756
    Oxysterol_BP; Oxysterol-binding protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    31660825..31981301 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264845.1XP_005264902.1  oxysterol-binding protein-related protein 10 isoform X5

    Conserved Domains (1) summary
    pfam01237
    Location:66420
    Oxysterol_BP; Oxysterol-binding protein
  2. XM_005264843.4XP_005264900.1  oxysterol-binding protein-related protein 10 isoform X1

    Conserved Domains (3) summary
    cd13291
    Location:77183
    PH_ORP10_ORP11; Human Oxysterol binding protein (OSBP) related proteins 10 and 11 (ORP10 and ORP11) Pleckstrin homology (PH) domain
    pfam00169
    Location:78171
    PH; PH domain
    pfam01237
    Location:402750
    Oxysterol_BP; Oxysterol-binding protein
  3. XM_005264844.5XP_005264901.1  oxysterol-binding protein-related protein 10 isoform X2

    Conserved Domains (3) summary
    cd13291
    Location:77179
    PH_ORP10_ORP11; Human Oxysterol binding protein (OSBP) related proteins 10 and 11 (ORP10 and ORP11) Pleckstrin homology (PH) domain
    pfam00169
    Location:78171
    PH; PH domain
    pfam01237
    Location:338686
    Oxysterol_BP; Oxysterol-binding protein
  4. XM_011533326.2XP_011531628.1  oxysterol-binding protein-related protein 10 isoform X3

    Conserved Domains (2) summary
    pfam01237
    Location:265613
    Oxysterol_BP; Oxysterol-binding protein
    cl17171
    Location:146
    PH-like; Pleckstrin homology-like domain
  5. XM_017005670.2XP_016861159.1  oxysterol-binding protein-related protein 10 isoform X4

    Related
    ENSP00000416078.2, ENST00000429492.6
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