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OSBPL7 oxysterol binding protein like 7 [ Homo sapiens (human) ]

Gene ID: 114881, updated on 1-Jun-2020

Summary

Official Symbol
OSBPL7provided by HGNC
Official Full Name
oxysterol binding protein like 7provided by HGNC
Primary source
HGNC:HGNC:16387
See related
Ensembl:ENSG00000006025 MIM:606735
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ORP7
Summary
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Two transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]
Expression
Broad expression in stomach (RPKM 18.4), duodenum (RPKM 12.5) and 22 other tissues See more
Orthologs

Genomic context

See OSBPL7 in Genome Data Viewer
Location:
17q21.32
Exon count:
23
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (47807367..47821822, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (45884733..45899169, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene TBK1 binding protein 1 Neighboring gene TBX21 promoter region Neighboring gene T-box transcription factor 21 Neighboring gene mitochondrial ribosomal protein L10 Neighboring gene leucine rich repeat containing 46 Neighboring gene secernin 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Biological, clinical and population relevance of 95 loci for blood lipids.
NHGRI GWA Catalog
Discovery and refinement of loci associated with lipid levels.
NHGRI GWA Catalog
Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of oxysterol binding protein-like 7 (OSBPL7) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC71150

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cholesterol binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cholesterol binding IDA
Inferred from Direct Assay
more info
PubMed 
lipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sterol binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sterol transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
bile acid biosynthetic process TAS
Traceable Author Statement
more info
 
cellular response to cholesterol IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of proteasomal protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of autophagy NAS
Non-traceable Author Statement
more info
PubMed 
sterol transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
autophagosome IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
perinuclear endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
perinuclear endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
oxysterol-binding protein-related protein 7
Names
ORP-7
OSBP-related protein 7

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145798.3NP_665741.1  oxysterol-binding protein-related protein 7

    See identical proteins and their annotated locations for NP_665741.1

    Status: REVIEWED

    Source sequence(s)
    AC003665, AF392446, BC065482, BM674891
    Consensus CDS
    CCDS11515.1
    UniProtKB/Swiss-Prot
    Q9BZF2
    UniProtKB/TrEMBL
    Q8WXP9
    Related
    ENSP00000007414.3, ENST00000007414.8
    Conserved Domains (3) summary
    cd13287
    Location:27149
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam00169
    Location:51139
    PH; PH domain
    pfam01237
    Location:478819
    Oxysterol_BP; Oxysterol-binding protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    47807367..47821822 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024124.1XP_016879613.1  oxysterol-binding protein-related protein 7 isoform X2

  2. XM_017024122.1XP_016879611.1  oxysterol-binding protein-related protein 7 isoform X1

  3. XM_017024123.1XP_016879612.1  oxysterol-binding protein-related protein 7 isoform X1

  4. XM_017024125.1XP_016879614.1  oxysterol-binding protein-related protein 7 isoform X3

RNA

  1. XR_001752423.1 RNA Sequence

  2. XR_934362.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_017731.4: Suppressed sequence

    Description
    NM_017731.4: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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