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Shc3 SHC adaptor protein 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 114858, updated on 3-Jun-2018
Official Symbol
Shc3provided by RGD
Official Full Name
SHC adaptor protein 3provided by RGD
Primary source
RGD:69348
See related
Ensembl:ENSRNOG00000014366
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ShcC
Summary
may be involved in brain-derived neurotrophic factor signalling during retinal development [RGD, Feb 2006]
Expression
Biased expression in Brain (RPKM 88.8), Adrenal (RPKM 22.8) and 2 other tissues See more
Orthologs
See Shc3 in Genome Data Viewer
Location:
17p14
Exon count:
12
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (13670520..13791043)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 17 NC_005116.3 (15743125..15862911)

Chromosome 17 - NC_005116.4Genomic Context describing neighboring genes Neighboring gene SECIS binding protein 2 Neighboring gene CDC28 protein kinase regulatory subunit 2 Neighboring gene uncharacterized LOC102556322 Neighboring gene sphingosine-1-phosphate receptor 3

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
phosphotyrosine residue binding IEA
Inferred from Electronic Annotation
more info
 
phosphotyrosine residue binding ISO
Inferred from Sequence Orthology
more info
 
phosphotyrosine residue binding TAS
Traceable Author Statement
more info
PubMed 
protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein tyrosine kinase activity TAS
Traceable Author Statement
more info
 
receptor tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
central nervous system development IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction TAS
Traceable Author Statement
more info
PubMed 
learning or memory ISO
Inferred from Sequence Orthology
more info
 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
intracellular IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
SHC-transforming protein 3
Names
N-Shc
SH2 domain protein C3
SHC (Src homology 2 domain containing) transforming protein 3
SHC-transforming protein C
neuronal Shc
src homology 2 domain-containing transforming protein C3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105743.1NP_001099213.1  SHC-transforming protein 3

    See identical proteins and their annotated locations for NP_001099213.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473977
    UniProtKB/TrEMBL
    G3V7V0
    Related
    ENSRNOP00000019442.2, ENSRNOT00000019442.3
    Conserved Domains (2) summary
    cd09925
    Location:492594
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:139310
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005116.4 Reference Rnor_6.0 Primary Assembly

    Range
    13670520..13791043
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000085.1 Alternate Rn_Celera

    Range
    13401154..13520906
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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