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Acvrl1 activin A receptor, type II-like 1 [ Mus musculus (house mouse) ]

Gene ID: 11482, updated on 8-Dec-2018

Summary

Official Symbol
Acvrl1provided by MGI
Official Full Name
activin A receptor, type II-like 1provided by MGI
Primary source
MGI:MGI:1338946
See related
Ensembl:ENSMUSG00000000530
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Alk1; Acvrlk1; AI115505; AI427544
Expression
Biased expression in lung adult (RPKM 194.2), subcutaneous fat pad adult (RPKM 18.5) and 5 other tissues See more
Orthologs

Genomic context

See Acvrl1 in Genome Data Viewer
Location:
15; 15 F1
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (101128522..101145336)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (100958968..100975767)

Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 41402 Neighboring gene ankyrin repeat domain 33 Neighboring gene activin A receptor, type 1B Neighboring gene microRNA 6962 Neighboring gene RIKEN cDNA A330009N23 gene Neighboring gene expressed sequence AU021063

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding ISO
Inferred from Sequence Orthology
more info
 
BMP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
BMP receptor activity ISO
Inferred from Sequence Orthology
more info
 
SMAD binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SMAD binding ISO
Inferred from Sequence Orthology
more info
 
activin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activin binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to activin receptor activity, type I IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activin receptor activity, type I ISO
Inferred from Sequence Orthology
more info
 
growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transforming growth factor beta binding ISO
Inferred from Sequence Orthology
more info
 
transforming growth factor beta receptor activity, type I IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transforming growth factor beta receptor activity, type I ISO
Inferred from Sequence Orthology
more info
 
transforming growth factor beta-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transforming growth factor beta-activated receptor activity ISO
Inferred from Sequence Orthology
more info
 
transmembrane receptor protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
angiogenesis ISO
Inferred from Sequence Orthology
more info
 
artery development IMP
Inferred from Mutant Phenotype
more info
PubMed 
blood circulation ISO
Inferred from Sequence Orthology
more info
 
blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
blood vessel remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to BMP stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to transforming growth factor beta stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to transforming growth factor beta stimulus ISO
Inferred from Sequence Orthology
more info
 
dorsal aorta morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
endocardial cushion morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT endocardial cushion to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
endothelial cell activation TAS
Traceable Author Statement
more info
PubMed 
endothelial tube morphogenesis ISO
Inferred from Sequence Orthology
more info
 
in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
lymphangiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
lymphatic endothelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
lymphatic endothelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endothelial cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
pattern specification process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of BMP signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of endothelial cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
retina vasculature development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction ISO
Inferred from Sequence Orthology
more info
 
transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
transmembrane receptor protein serine/threonine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
venous blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
wound healing, spreading of epidermal cells ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
activin receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
 
dendrite ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase receptor R3
Names
SKR3
TGF-B superfamily receptor type I
TSR-I
activin receptor-like kinase 1
NP_001264184.1
NP_001264186.1
NP_001264187.1
NP_001264188.1
NP_033742.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277255.1NP_001264184.1  serine/threonine-protein kinase receptor R3 isoform b

    See identical proteins and their annotated locations for NP_001264184.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and uses an upstream in-frame AUG translation start codon compared to variant 1. The resulting isoform (b) is longer at the N-terminus compared to isoform a.
    Source sequence(s)
    AC104834, AK134712, BB869400
    Conserved Domains (4) summary
    cd14142
    Location:210507
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
    pfam07714
    Location:216503
    Pkinase_Tyr; Protein tyrosine kinase
    pfam08515
    Location:187214
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
    cl10471
    Location:48112
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
  2. NM_001277257.1NP_001264186.1  serine/threonine-protein kinase receptor R3 isoform a precursor

    See identical proteins and their annotated locations for NP_001264186.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 all encode the same isoform (a).
    Source sequence(s)
    AC104834, AK134712, BB869400
    Consensus CDS
    CCDS37215.1
    UniProtKB/Swiss-Prot
    Q61288
    Related
    ENSMUSP00000113505.1, ENSMUST00000117984.7
    Conserved Domains (4) summary
    cd14142
    Location:195492
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
    pfam07714
    Location:201488
    Pkinase_Tyr; Protein tyrosine kinase
    pfam08515
    Location:172199
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
    cl10471
    Location:3397
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
  3. NM_001277258.1NP_001264187.1  serine/threonine-protein kinase receptor R3 isoform a precursor

    See identical proteins and their annotated locations for NP_001264187.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 all encode the same isoform (a).
    Source sequence(s)
    AC104834, AK134712, AK160915
    Consensus CDS
    CCDS37215.1
    UniProtKB/Swiss-Prot
    Q61288
    Related
    ENSMUSP00000113536.1, ENSMUST00000119063.7
    Conserved Domains (4) summary
    cd14142
    Location:195492
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
    pfam07714
    Location:201488
    Pkinase_Tyr; Protein tyrosine kinase
    pfam08515
    Location:172199
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
    cl10471
    Location:3397
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
  4. NM_001277259.1NP_001264188.1  serine/threonine-protein kinase receptor R3 isoform a precursor

    See identical proteins and their annotated locations for NP_001264188.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 all encode the same isoform (a).
    Source sequence(s)
    AC104834, AK134712, AK160915
    Consensus CDS
    CCDS37215.1
    UniProtKB/Swiss-Prot
    Q61288
    Related
    ENSMUSP00000113297.1, ENSMUST00000120028.7
    Conserved Domains (4) summary
    cd14142
    Location:195492
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
    pfam07714
    Location:201488
    Pkinase_Tyr; Protein tyrosine kinase
    pfam08515
    Location:172199
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
    cl10471
    Location:3397
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
  5. NM_009612.3NP_033742.2  serine/threonine-protein kinase receptor R3 isoform a precursor

    See identical proteins and their annotated locations for NP_033742.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the predominant isoform (a). Variants 1, 2, 3, and 4 all encode the same isoform (a).
    Source sequence(s)
    AC104834, AK134712, BB869983
    Consensus CDS
    CCDS37215.1
    UniProtKB/Swiss-Prot
    Q61288
    Related
    ENSMUSP00000000542.7, ENSMUST00000000542.13
    Conserved Domains (4) summary
    cd14142
    Location:195492
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
    pfam07714
    Location:201488
    Pkinase_Tyr; Protein tyrosine kinase
    pfam08515
    Location:172199
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
    cl10471
    Location:3397
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

    Range
    101128522..101145336
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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