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PWWP2A PWWP domain containing 2A [ Homo sapiens (human) ]

Gene ID: 114825, updated on 4-Jul-2021

Summary

Official Symbol
PWWP2Aprovided by HGNC
Official Full Name
PWWP domain containing 2Aprovided by HGNC
Primary source
HGNC:HGNC:29406
See related
Ensembl:ENSG00000170234 MIM:617823
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MST101
Expression
Ubiquitous expression in colon (RPKM 1.9), skin (RPKM 1.8) and 25 other tissues See more
Orthologs
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Genomic context

See PWWP2A in Genome Data Viewer
Location:
5q33.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (160043538..160120701, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (159502889..159546457, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927790 Neighboring gene adrenoceptor alpha 1B Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 40 Neighboring gene tetratricopeptide repeat domain 1 Neighboring gene Sharpr-MPRA regulatory region 721 Neighboring gene FABP6 antisense RNA 1 Neighboring gene fatty acid binding protein 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1935, MGC132770

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
PWWP domain-containing protein 2A
Names
MSTP101

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130864.2NP_001124336.1  PWWP domain-containing protein 2A isoform b

    See identical proteins and their annotated locations for NP_001124336.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site at its 3'-terminal exon, compared to variant 1, which results in a protein (isoform B) with a longer and distinct C-terminus, compared to isoform A.
    Source sequence(s)
    AC008706, AI972512, AK055921, BC018680, BC105110, DB450981
    Consensus CDS
    CCDS47332.1
    UniProtKB/Swiss-Prot
    Q96N64
    Related
    ENSP00000305151.7, ENST00000307063.9
    Conserved Domains (1) summary
    cd05835
    Location:653739
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
  2. NM_001267035.3NP_001253964.1  PWWP domain-containing protein 2A isoform c

    See identical proteins and their annotated locations for NP_001253964.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the 3' coding region, compared to variant 1, which results in a protein (isoform C) with a shorter C-terminus, compared to isoform A.
    Source sequence(s)
    AC008706, BC039106, BC143437, BI548991, CB218424, DB450981
    Consensus CDS
    CCDS58990.1
    UniProtKB/Swiss-Prot
    Q96N64
    Related
    ENSP00000428143.1, ENST00000523662.1
  3. NM_001349732.2NP_001336661.1  PWWP domain-containing protein 2A isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in its 5' UTR, and its 3' terminal exon extends past a splice site that is used in variant 1. These differences cause translation initiation at a downstream start codon and results in a novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (d) has a shorter N-terminus and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC008706, AI288438, AI972512, AK055921, BC018680, BC105110, DB450981
    Conserved Domains (1) summary
    cd05835
    Location:436522
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
  4. NM_001349733.2NP_001336662.1  PWWP domain-containing protein 2A isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains an alternate exon in the 5' region, resulting in use of a downstream start codon compared to variant 1. The encoded isoform (e) has a shorter N-terminus than isoform a.
    Source sequence(s)
    AC008706, AI288438, AV720552, BC035076, BC039106, BC105110, CB218424, DB450981
  5. NM_001349734.2NP_001336663.1  PWWP domain-containing protein 2A isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains two consecutive alternate exons in the 5' region, and lacks an alternate in-frame exon in the 3' coding region compared to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (f) with a shorter N-terminus and lacking an internal segment, compared to isoform a. Variants 6 and 7 encode the same protein (isoform f).
    Source sequence(s)
    AC008706, AI288438, BC039106, BC105110, BC143437, CB218424, DB450981
  6. NM_001349735.2NP_001336664.1  PWWP domain-containing protein 2A isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) contains an alternate exon in the 5' region, and lacks an alternate in-frame exon in the 3' coding region compared to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (f) with a shorter N-terminus and lacking an internal segment, compared to isoform a. Variants 6 and 7 encode the same protein (isoform f).
    Source sequence(s)
    AC008706, AI288438, BC039106, BC143437, BI548991, CB218424, DB450981
  7. NM_052927.4NP_443159.1  PWWP domain-containing protein 2A isoform a

    See identical proteins and their annotated locations for NP_443159.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AC008706, AV720552, BC035076, BC039106, BC105110, CB218424, DB450981
    Consensus CDS
    CCDS47331.1
    UniProtKB/Swiss-Prot
    Q96N64
    Related
    ENSP00000390462.2, ENST00000456329.7
    Conserved Domains (1) summary
    PTZ00121
    Location:323464
    PTZ00121; MAEBL; Provisional

RNA

  1. NR_146216.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC008706, AV720552, BC035076, BC039106, BC105110, CB218424, CN336545, DB450981
  2. NR_146217.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) contains two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC008706, AI288438, AV720552, BC035076, BC039106, BC105110, CB218424, CN336545, DB450981

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    160043538..160120701 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534424.3XP_011532726.1  PWWP domain-containing protein 2A isoform X1

  2. XM_017009012.2XP_016864501.1  PWWP domain-containing protein 2A isoform X3

  3. XM_024454354.1XP_024310122.1  PWWP domain-containing protein 2A isoform X5

  4. XM_024454353.1XP_024310121.1  PWWP domain-containing protein 2A isoform X4

  5. XM_005265812.3XP_005265869.1  PWWP domain-containing protein 2A isoform X2

    See identical proteins and their annotated locations for XP_005265869.1

    Conserved Domains (1) summary
    cd05835
    Location:436522
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
  6. XM_017009010.1XP_016864499.1  PWWP domain-containing protein 2A isoform X2

    Conserved Domains (1) summary
    cd05835
    Location:436522
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
  7. XM_017009011.1XP_016864500.1  PWWP domain-containing protein 2A isoform X2

    Conserved Domains (1) summary
    cd05835
    Location:436522
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
  8. XM_005265811.3XP_005265868.1  PWWP domain-containing protein 2A isoform X2

    See identical proteins and their annotated locations for XP_005265868.1

    Conserved Domains (1) summary
    cd05835
    Location:436522
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

RNA

  1. XR_001741991.1 RNA Sequence

  2. XR_427800.3 RNA Sequence

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