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LENG8 leukocyte receptor cluster member 8 [ Homo sapiens (human) ]

Gene ID: 114823, updated on 4-Dec-2022

Summary

Official Symbol
LENG8provided by HGNC
Official Full Name
leukocyte receptor cluster member 8provided by HGNC
Primary source
HGNC:HGNC:15500
See related
Ensembl:ENSG00000167615 MIM:616575; AllianceGenome:HGNC:15500
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
pp13842
Summary
Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen (RPKM 65.5), endometrium (RPKM 49.9) and 24 other tissues See more
Orthologs
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Try the new Transcript table

Genomic context

See LENG8 in Genome Data Viewer
Location:
19q13.42
Exon count:
16
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (54449199..54462016)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (57542477..57555296)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (54960377..54973196)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene tweety family member 1 Neighboring gene Sharpr-MPRA regulatory region 3780 Neighboring gene LENG8 antisense RNA 1 Neighboring gene CDC42 effector protein 5 Neighboring gene leukocyte receptor cluster member 9 Neighboring gene leukocyte associated immunoglobulin like receptor 2

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1932, MGC40108

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
leukocyte receptor cluster member 8
Names
leukocyte receptor cluster (LRC) member 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001375638.1NP_001362567.1  leukocyte receptor cluster member 8 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC245884
    Consensus CDS
    CCDS92685.1
    UniProtKB/TrEMBL
    A0A087WUE4
    Conserved Domains (2) summary
    pfam09770
    Location:126266
    PAT1; Topoisomerase II-associated protein PAT1
    cl24019
    Location:567757
    CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family
  2. NM_001375639.1NP_001362568.1  leukocyte receptor cluster member 8 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC245884
    Conserved Domains (2) summary
    pfam09770
    Location:108248
    PAT1; Topoisomerase II-associated protein PAT1
    cl24019
    Location:549739
    CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family
  3. NM_001375640.1NP_001362569.1  leukocyte receptor cluster member 8 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC245884
    Consensus CDS
    CCDS92685.1
    UniProtKB/TrEMBL
    A0A087WUE4
    Related
    ENSP00000478590.1, ENST00000610347.1
    Conserved Domains (2) summary
    pfam09770
    Location:126266
    PAT1; Topoisomerase II-associated protein PAT1
    cl24019
    Location:567757
    CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family
  4. NM_001375641.1NP_001362570.1  leukocyte receptor cluster member 8 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC245884
    Consensus CDS
    CCDS92685.1
    UniProtKB/TrEMBL
    A0A087WUE4
    Conserved Domains (2) summary
    pfam09770
    Location:126266
    PAT1; Topoisomerase II-associated protein PAT1
    cl24019
    Location:567757
    CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family
  5. NM_001411063.1NP_001397992.1  leukocyte receptor cluster member 8 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC245884
    Consensus CDS
    CCDS92686.1
    UniProtKB/TrEMBL
    C9JMY0
  6. NM_052925.4NP_443157.1  leukocyte receptor cluster member 8 isoform 3

    See identical proteins and their annotated locations for NP_443157.1

    Status: VALIDATED

    Source sequence(s)
    BC028048, HY032958
    Consensus CDS
    CCDS12894.1
    UniProtKB/Swiss-Prot
    Q8NCX6, Q96PV6
    UniProtKB/TrEMBL
    A0A024R4R9
    Related
    ENSP00000318374.5, ENST00000326764.10
    Conserved Domains (2) summary
    pfam09770
    Location:126266
    PAT1; Topoisomerase II-associated protein PAT1
    cl24019
    Location:567778
    CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    54449199..54462016
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005278252.6XP_005278309.1  leukocyte receptor cluster member 8 isoform X2

    See identical proteins and their annotated locations for XP_005278309.1

    UniProtKB/TrEMBL
    C9JMY0
    Conserved Domains (2) summary
    pfam03399
    Location:531720
    SAC3_GANP; SAC3/GANP/Nin1/mts3/eIF-3 p25 family
    pfam12346
    Location:426512
    HJURP_mid; Holliday junction recognition protein-associated repeat
  2. XM_047438126.1XP_047294082.1  leukocyte receptor cluster member 8 isoform X5

    Related
    ENSP00000477813.1, ENST00000616932.4
  3. XM_006722997.5XP_006723060.1  leukocyte receptor cluster member 8 isoform X3

    See identical proteins and their annotated locations for XP_006723060.1

    Conserved Domains (2) summary
    pfam03399
    Location:513702
    SAC3_GANP; SAC3/GANP/Nin1/mts3/eIF-3 p25 family
    pfam12346
    Location:408494
    HJURP_mid; Holliday junction recognition protein-associated repeat
  4. XM_011526415.4XP_011524717.1  leukocyte receptor cluster member 8 isoform X4

    See identical proteins and their annotated locations for XP_011524717.1

    UniProtKB/Swiss-Prot
    Q8NCX6, Q96PV6
    UniProtKB/TrEMBL
    A0A024R4R9
    Conserved Domains (2) summary
    pfam09770
    Location:126266
    PAT1; Topoisomerase II-associated protein PAT1
    cl24019
    Location:567778
    CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family
  5. XM_011526414.4XP_011524716.1  leukocyte receptor cluster member 8 isoform X2

    See identical proteins and their annotated locations for XP_011524716.1

    UniProtKB/TrEMBL
    C9JMY0
    Related
    ENSP00000365697.3, ENST00000376514.6
    Conserved Domains (2) summary
    pfam03399
    Location:531720
    SAC3_GANP; SAC3/GANP/Nin1/mts3/eIF-3 p25 family
    pfam12346
    Location:426512
    HJURP_mid; Holliday junction recognition protein-associated repeat
  6. XM_047438125.1XP_047294081.1  leukocyte receptor cluster member 8 isoform X5

  7. XM_005278250.6XP_005278307.1  leukocyte receptor cluster member 8 isoform X1

    See identical proteins and their annotated locations for XP_005278307.1

    Conserved Domains (2) summary
    pfam09770
    Location:108248
    PAT1; Topoisomerase II-associated protein PAT1
    cl24019
    Location:549739
    CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family
  8. XM_047438124.1XP_047294080.1  leukocyte receptor cluster member 8 isoform X4

    UniProtKB/Swiss-Prot
    Q8NCX6
    UniProtKB/TrEMBL
    A0A024R4R9
  9. XM_047438123.1XP_047294079.1  leukocyte receptor cluster member 8 isoform X2

  10. XM_047438127.1XP_047294083.1  leukocyte receptor cluster member 8 isoform X5

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NW_003571054.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    355711..368530
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_7

Genomic

  1. NW_003571060.1 Reference GRCh38.p14 ALT_REF_LOCI_7

    Range
    353885..366704
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_9

Genomic

  1. NT_187693.1 Reference GRCh38.p14 ALT_REF_LOCI_9

    Range
    431491..444310
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    57542477..57555296
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)