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LENG8 leukocyte receptor cluster member 8 [ Homo sapiens (human) ]

Gene ID: 114823, updated on 6-Jul-2026
Official Symbol
LENG8provided by HGNC
Official Full Name
leukocyte receptor cluster member 8provided by HGNC
Primary source
HGNC:HGNC:15500
See related
Ensembl:ENSG00000167615 MIM:616575; AllianceGenome:HGNC:15500
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
pp13842
Summary
Predicted to be part of protein-containing complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in spleen (RPKM 65.5), endometrium (RPKM 49.9) and 24 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See LENG8 in Genome Data Viewer
Location:
19q13.42
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (54449199..54462016)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (57542477..57555296)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (54960377..54973196)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene LIM domain-containing protein A-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54933359-54934162 Neighboring gene tweety family member 1 Neighboring gene Sharpr-MPRA regulatory region 3780 Neighboring gene LENG8 antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:54960127-54961034 Neighboring gene CDC42 effector protein 5 Neighboring gene leukocyte receptor cluster member 9 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_51709 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55018677-55019177 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55020667-55021482 Neighboring gene leukocyte associated immunoglobulin like receptor 2

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Screening the full leucocyte receptor complex genomic region revealed associations with pemphigus that might be explained by gene regulation. Farias TDJ, et al. Immunology, 2019 Jan. PMID 30216441, Free PMC Article
  2. Soluble bovine galactose-binding lectin. cDNA cloning reveals the complete amino acid sequence and an antigenic relationship with the major encephalitogenic domain of myelin basic protein. Abbott WM, et al. Biochem J, 1989 Apr 1. PMID 2470348, Free PMC Article
  3. Affinity proteomic dissection of the human nuclear cap-binding complex interactome. Dou Y, et al. Nucleic Acids Res, 2020 Oct 9. PMID 32960270, Free PMC Article
  4. Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. Wende H, et al. Immunogenetics, 2000 Jul. PMID 10941842
  5. mRNA export through an additional cap-binding complex consisting of NCBP1 and NCBP3. Gebhardt A, et al. Nat Commun, 2015 Sep 18. PMID 26382858, Free PMC Article

See all (81) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. genetic polymorphism is associated with pemphigus foliaceus
    Title: Screening the full leucocyte receptor complex genomic region revealed associations with pemphigus that might be explained by gene regulation.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA1932, MGC40108

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
leukocyte receptor cluster member 8
Names
leukocyte receptor cluster (LRC) member 8

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001375638.1 → NP_001362567.1  leukocyte receptor cluster member 8 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC245884
    Consensus CDS
    CCDS92685.1
    UniProtKB/TrEMBL
    A0A087WUE4, A0A0G2JNN3
    Conserved Domains (2) summary
    pfam09770
    Location:126 → 266
    PAT1; Topoisomerase II-associated protein PAT1
    cl24019
    Location:567 → 757
    CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family

  2. NM_001375639.1 → NP_001362568.1  leukocyte receptor cluster member 8 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC245884
    UniProtKB/TrEMBL
    A0A0G2JNN3
    Conserved Domains (2) summary
    pfam09770
    Location:108 → 248
    PAT1; Topoisomerase II-associated protein PAT1
    cl24019
    Location:549 → 739
    CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family

  3. NM_001375640.1 → NP_001362569.1  leukocyte receptor cluster member 8 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC245884
    Consensus CDS
    CCDS92685.1
    UniProtKB/TrEMBL
    A0A087WUE4, A0A0G2JNN3
    Related
    ENSP00000478590.1, ENST00000610347.1
    Conserved Domains (2) summary
    pfam09770
    Location:126 → 266
    PAT1; Topoisomerase II-associated protein PAT1
    cl24019
    Location:567 → 757
    CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family

  4. NM_001375641.1 → NP_001362570.1  leukocyte receptor cluster member 8 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC245884
    Consensus CDS
    CCDS92685.1
    UniProtKB/TrEMBL
    A0A087WUE4, A0A0G2JNN3
    Conserved Domains (2) summary
    pfam09770
    Location:126 → 266
    PAT1; Topoisomerase II-associated protein PAT1
    cl24019
    Location:567 → 757
    CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family

  5. NM_001411063.1 → NP_001397992.1  leukocyte receptor cluster member 8 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC245884
    Consensus CDS
    CCDS92686.1
    UniProtKB/TrEMBL
    A0A0G2JNN3, C9JMY0

  6. NM_001437985.1 → NP_001424914.1  leukocyte receptor cluster member 8 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC245884
    UniProtKB/TrEMBL
    A0A0G2JNN3, C9JMY0
    Related
    ENSP00000365697.3, ENST00000376514.6

  7. NM_001438283.1 → NP_001425212.1  leukocyte receptor cluster member 8 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC245884
    UniProtKB/TrEMBL
    A0A0G2JNN3

  8. NM_001438284.1 → NP_001425213.1  leukocyte receptor cluster member 8 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC245884
    UniProtKB/TrEMBL
    A0A0G2JNN3, C9JMY0

  9. NM_001438285.1 → NP_001425214.1  leukocyte receptor cluster member 8 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC245884
    UniProtKB/TrEMBL
    A0A0G2JNN3

  10. NM_001438286.1 → NP_001425215.1  leukocyte receptor cluster member 8 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC245884
    UniProtKB/Swiss-Prot
    A0A087WTE7, B0VJY9, Q8IZ27, Q8NCX6, Q96PV6
    UniProtKB/TrEMBL
    A0ACI8QRD1
    Related
    ENSP00000557026.1, ENST00000886967.1

  11. NM_001438287.1 → NP_001425216.1  leukocyte receptor cluster member 8 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC245884
    UniProtKB/Swiss-Prot
    A0A087WTE7, B0VJY9, Q8IZ27, Q8NCX6, Q96PV6
    UniProtKB/TrEMBL
    A0ACI8QRD1

  12. NM_001438288.1 → NP_001425217.1  leukocyte receptor cluster member 8 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC245884
    UniProtKB/TrEMBL
    A0ACI8Q9C5, A0ACI8QRD1
    Related
    ENSP00000557024.1, ENST00000886965.1

  13. NM_001438289.1 → NP_001425218.1  leukocyte receptor cluster member 8 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC245884
    UniProtKB/TrEMBL
    A0ACI8Q9C5, A0ACI8QRD1
    Related
    ENSP00000557025.1, ENST00000886966.1

  14. NM_001438290.1 → NP_001425219.1  leukocyte receptor cluster member 8 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC245884
    UniProtKB/TrEMBL
    A0ACI8Q9C5, A0ACI8QRD1

  15. NM_052925.4 → NP_443157.1  leukocyte receptor cluster member 8 isoform 3

    See identical proteins and their annotated locations for NP_443157.1

    Status: VALIDATED

    Source sequence(s)
    BC028048, HY032958
    Consensus CDS
    CCDS12894.1
    UniProtKB/Swiss-Prot
    A0A087WTE7, B0VJY9, Q8IZ27, Q8NCX6, Q96PV6
    UniProtKB/TrEMBL
    A0ACI8QRD1
    Related
    ENSP00000318374.5, ENST00000326764.10
    Conserved Domains (2) summary
    pfam09770
    Location:126 → 266
    PAT1; Topoisomerase II-associated protein PAT1
    cl24019
    Location:567 → 778
    CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    54449199..54462016
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NW_003571054.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    355711..368530
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_7

Genomic

  1. NW_003571060.1 Reference GRCh38.p14 ALT_REF_LOCI_7

    Range
    353885..366704
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_008485718.1 RNA Sequence

Reference GRCh38.p14 ALT_REF_LOCI_9

Genomic

  1. NT_187693.1 Reference GRCh38.p14 ALT_REF_LOCI_9

    Range
    431491..444310
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_008485852.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    57542477..57555296
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_008485078.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96PV6.3 GenPept UniProtKB/Swiss-Prot:Q96PV6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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