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RHPN1 rhophilin Rho GTPase binding protein 1 [ Homo sapiens (human) ]

Gene ID: 114822, updated on 25-May-2017
Official Symbol
RHPN1provided by HGNC
Official Full Name
rhophilin Rho GTPase binding protein 1provided by HGNC
Primary source
HGNC:HGNC:19973
See related
Ensembl:ENSG00000158106 MIM:601031; Vega:OTTHUMG00000165006
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ODF5; RHPN; RHOPHILIN
Orthologs
Location:
8q24.3
Exon count:
18
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 8 NC_000008.11 (143368827..143384220)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (144451025..144466390)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene topoisomerase (DNA) I, mitochondrial Neighboring gene RNA, U6 small nuclear 220, pseudogene Neighboring gene RHPN1 antisense RNA 1 (head to head) Neighboring gene uncharacterized LOC107986984 Neighboring gene MAFA antisense RNA 1

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag The isolated Bro1 domains of HD-PTP and rhophilin both bind to HIV-1 NC and share the capacity to stimulate VLP production by a minimal HIV-1 Gag molecule PubMed
nucleocapsid gag The isolated Bro1 domains of HD-PTP and rhophilin both bind to HIV-1 NC and share the capacity to stimulate VLP production by a minimal HIV-1 Gag molecule PubMed

Go to the HIV-1, Human Interaction Database

  • Ectoderm Differentiation, organism-specific biosystem (from WikiPathways)
    Ectoderm Differentiation, organism-specific biosystemModel depicting ectoderm specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell lin...
  • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
    RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
  • RHO GTPases Activate Rhotekin and Rhophilins, organism-specific biosystem (from REACTOME)
    RHO GTPases Activate Rhotekin and Rhophilins, organism-specific biosystemRhotekin (RTKN) is a protein with an N-terminally located RHO GTPase binding domain, that shares a limited sequence homology with PKNs and rhophilins. RTKN binds to GTP-bound RHOA, RHOB and RHOC and ...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
Products Interactant Other Gene Complex Source Pubs Description

Homology

Clone Names

  • KIAA1929

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
Preferred Names
rhophilin-1
Names
GTP-Rho-binding protein 1
outer dense fiber of sperm tails 5

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052924.2NP_443156.2  rhophilin-1

    See identical proteins and their annotated locations for NP_443156.2

    Status: VALIDATED

    Source sequence(s)
    AC105118, BC025767, BX341691
    Consensus CDS
    CCDS47927.1
    UniProtKB/Swiss-Prot
    Q8TCX5
    Related
    ENSP00000289013.6, OTTHUMP00000228179, ENST00000289013.10, OTTHUMT00000381417
    Conserved Domains (3) summary
    cd09248
    Location:109493
    BRO1_Rhophilin_1; Protein-interacting Bro1-like domain of RhoA-binding protein Rhophilin-1
    smart00228
    Location:514580
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cl00087
    Location:21105
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p7 Primary Assembly

    Range
    143368827..143384220
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516823.2XP_011515125.1  rhophilin-1 isoform X10

    Conserved Domains (2) summary
    cl00087
    Location:74158
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    cl14649
    Location:162529
    BRO1_Alix_like; Protein-interacting Bro1-like domain of mammalian Alix and related domains
  2. XM_017013014.1XP_016868503.1  rhophilin-1 isoform X11

  3. XM_017013013.1XP_016868502.1  rhophilin-1 isoform X6

  4. XM_011516817.2XP_011515119.1  rhophilin-1 isoform X1

    Conserved Domains (3) summary
    cd09248
    Location:162552
    BRO1_Rhophilin_1; Protein-interacting Bro1-like domain of RhoA-binding protein Rhophilin-1
    smart00228
    Location:573639
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cl00087
    Location:74158
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
  5. XM_006716502.3XP_006716565.1  rhophilin-1 isoform X2

    Conserved Domains (3) summary
    cd09248
    Location:162551
    BRO1_Rhophilin_1; Protein-interacting Bro1-like domain of RhoA-binding protein Rhophilin-1
    smart00228
    Location:572638
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cl00087
    Location:74158
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
  6. XM_005250772.3XP_005250829.1  rhophilin-1 isoform X3

    See identical proteins and their annotated locations for XP_005250829.1

    Conserved Domains (3) summary
    cd09248
    Location:162546
    BRO1_Rhophilin_1; Protein-interacting Bro1-like domain of RhoA-binding protein Rhophilin-1
    smart00228
    Location:567633
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cl00087
    Location:74158
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
  7. XM_017013016.1XP_016868505.1  rhophilin-1 isoform X13

  8. XM_005250773.3XP_005250830.1  rhophilin-1 isoform X4

    Conserved Domains (3) summary
    cd09248
    Location:162545
    BRO1_Rhophilin_1; Protein-interacting Bro1-like domain of RhoA-binding protein Rhophilin-1
    smart00228
    Location:566632
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cl00087
    Location:74158
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
  9. XM_011516819.2XP_011515121.1  rhophilin-1 isoform X7

    Conserved Domains (3) summary
    cd09248
    Location:109499
    BRO1_Rhophilin_1; Protein-interacting Bro1-like domain of RhoA-binding protein Rhophilin-1
    smart00228
    Location:520586
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cl00087
    Location:21105
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
  10. XM_011516822.2XP_011515124.1  rhophilin-1 isoform X9

    See identical proteins and their annotated locations for XP_011515124.1

    Conserved Domains (3) summary
    cd09248
    Location:60450
    BRO1_Rhophilin_1; Protein-interacting Bro1-like domain of RhoA-binding protein Rhophilin-1
    smart00228
    Location:471537
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cl00087
    Location:156
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
  11. XM_017013015.1XP_016868504.1  rhophilin-1 isoform X12

  12. XM_011516818.1XP_011515120.1  rhophilin-1 isoform X5

    Conserved Domains (3) summary
    cd09248
    Location:145535
    BRO1_Rhophilin_1; Protein-interacting Bro1-like domain of RhoA-binding protein Rhophilin-1
    smart00228
    Location:556622
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cl00087
    Location:57141
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
  13. XM_011516821.2XP_011515123.1  rhophilin-1 isoform X9

    See identical proteins and their annotated locations for XP_011515123.1

    Conserved Domains (3) summary
    cd09248
    Location:60450
    BRO1_Rhophilin_1; Protein-interacting Bro1-like domain of RhoA-binding protein Rhophilin-1
    smart00228
    Location:471537
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cl00087
    Location:156
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
  14. XM_011516820.2XP_011515122.1  rhophilin-1 isoform X8

    Conserved Domains (3) summary
    cd09248
    Location:97487
    BRO1_Rhophilin_1; Protein-interacting Bro1-like domain of RhoA-binding protein Rhophilin-1
    smart00228
    Location:508574
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cl00087
    Location:993
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

RNA

  1. XR_001745465.1 RNA Sequence

    Related
    ENST00000522335.5

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 Alternate CHM1_1.1

    Range
    144491261..144506805
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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