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Acvr2b activin receptor IIB [ Mus musculus (house mouse) ]

Gene ID: 11481, updated on 12-May-2024

Summary

Official Symbol
Acvr2bprovided by MGI
Official Full Name
activin receptor IIBprovided by MGI
Primary source
MGI:MGI:87912
See related
Ensembl:ENSMUSG00000061393 AllianceGenome:MGI:87912
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ActRIIB; AI047905; 4930516B21Rik
Summary
Enables activin binding activity; growth factor binding activity; and protein kinase activity. Involved in blood vessel remodeling; negative regulation of cold-induced thermogenesis; and vasculature development. Acts upstream of or within several processes, including animal organ development; embryonic morphogenesis; and insulin secretion. Predicted to be located in cytoplasm. Predicted to be part of activin receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; egg cylinder; genitourinary system; nervous system; and sensory organ. Used to study right atrial isomerism and visceral heterotaxy. Human ortholog(s) of this gene implicated in visceral heterotaxy. Orthologous to human ACVR2B (activin A receptor type 2B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 12.1), whole brain E14.5 (RPKM 7.8) and 20 other tissues See more
Orthologs
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Genomic context

See Acvr2b in Genome Data Viewer
Location:
9; 9 F3
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (119231081..119271214)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (119401583..119442148)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene xylulokinase homolog (H. influenzae) Neighboring gene predicted gene, 53515 Neighboring gene STARR-positive B cell enhancer mm9_chr9:119353850-119354151 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:119374205-119374506 Neighboring gene exo/endonuclease G Neighboring gene STARR-seq mESC enhancer starr_25473 Neighboring gene sodium channel, voltage-gated, type V, alpha

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (6)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC118477

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables activin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables activin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables activin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables activin binding ISO
Inferred from Sequence Orthology
more info
 
enables activin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables activin receptor activity, type II ISO
Inferred from Sequence Orthology
more info
 
enables growth factor binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables growth factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables inhibin binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine/tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
NOT enables transforming growth factor beta binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transmembrane receptor protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in activin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in activin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within anterior/posterior pattern specification IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in anterior/posterior pattern specification ISO
Inferred from Sequence Orthology
more info
 
involved_in artery development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in blood vessel remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell surface receptor protein serine/threonine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to growth factor stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within determination of left/right symmetry IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within determination of left/right symmetry IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic foregut morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within gastrulation with mouth forming second IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within heart development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within insulin secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within kidney development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lung development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in lymphangiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lymphatic endothelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mesoderm development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within odontogenesis of dentin-containing tooth IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within odontogenesis of dentin-containing tooth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within organ growth IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within pancreas development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within pattern specification process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of activin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within post-embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within post-embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to glucose IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in retina vasculature development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within roof of mouth development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within roof of mouth development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within skeletal system development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within skeletal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within skeletal system morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within skeletal system morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in venous blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of activin receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
activin receptor type-2B
Names
activin receptor type IIB
NP_001300686.1
NP_031423.1
XP_006511989.1
XP_030099886.1
XP_036010460.1
XP_036010461.1
XP_036010462.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313757.1NP_001300686.1  activin receptor type-2B isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC166052
    Consensus CDS
    CCDS90681.1
    UniProtKB/Swiss-Prot
    P27040
    Related
    ENSMUSP00000150566.2, ENSMUST00000215746.2
    Conserved Domains (2) summary
    cd14140
    Location:194484
    STKc_ACVR2b; Catalytic domain of the Serine/Threonine Kinase, Activin Type IIB Receptor
    pfam01064
    Location:41110
    Activin_recp; Activin types I and II receptor domain
  2. NM_007397.3NP_031423.1  activin receptor type-2B precursor

    See identical proteins and their annotated locations for NP_031423.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC166052
    Consensus CDS
    CCDS23615.1
    UniProtKB/Swiss-Prot
    P27040, Q3KQI1
    Related
    ENSMUSP00000126108.2, ENSMUST00000165044.3
    Conserved Domains (3) summary
    smart00220
    Location:222495
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14140
    Location:218508
    STKc_ACVR2b; Catalytic domain of the Serine/Threonine Kinase, Activin Type IIB Receptor
    pfam01064
    Location:39117
    Activin_recp; Activin types I and II receptor domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    119231081..119271214
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511926.5XP_006511989.1  activin receptor type-2B isoform X4

    UniProtKB/Swiss-Prot
    P27040
    Conserved Domains (2) summary
    cd14140
    Location:186476
    STKc_ACVR2b; Catalytic domain of the Serine/Threonine Kinase, Activin Type IIB Receptor
    pfam01064
    Location:41110
    Activin_recp; Activin types I and II receptor domain
  2. XM_030244026.2XP_030099886.1  activin receptor type-2B isoform X5

    Conserved Domains (1) summary
    cd14140
    Location:36326
    STKc_ACVR2b; Catalytic domain of the Serine/Threonine Kinase, Activin Type IIB Receptor
  3. XM_036154567.1XP_036010460.1  activin receptor type-2B isoform X1

    Conserved Domains (2) summary
    cd14140
    Location:239529
    STKc_ACVR2b; Catalytic domain of the Serine/Threonine Kinase, Activin Type IIB Receptor
    pfam01064
    Location:62131
    Activin_recp; Activin types I and II receptor domain
  4. XM_036154568.1XP_036010461.1  activin receptor type-2B isoform X2

    Conserved Domains (2) summary
    cd14140
    Location:215505
    STKc_ACVR2b; Catalytic domain of the Serine/Threonine Kinase, Activin Type IIB Receptor
    pfam01064
    Location:62131
    Activin_recp; Activin types I and II receptor domain
  5. XM_036154569.1XP_036010462.1  activin receptor type-2B isoform X3

    Conserved Domains (2) summary
    cd14140
    Location:207497
    STKc_ACVR2b; Catalytic domain of the Serine/Threonine Kinase, Activin Type IIB Receptor
    pfam01064
    Location:62131
    Activin_recp; Activin types I and II receptor domain

RNA

  1. XR_004935309.1 RNA Sequence