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RNF157 ring finger protein 157 [ Homo sapiens (human) ]

Gene ID: 114804, updated on 11-Jun-2021

Summary

Official Symbol
RNF157provided by HGNC
Official Full Name
ring finger protein 157provided by HGNC
Primary source
HGNC:HGNC:29402
See related
Ensembl:ENSG00000141576
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in brain (RPKM 16.0), testis (RPKM 13.4) and 11 other tissues See more
Orthologs
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Genomic context

See RNF157 in Genome Data Viewer
Location:
17q25.1
Exon count:
22
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (76142456..76240493, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (74138555..74236574, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928447 Neighboring gene RNF157 antisense RNA 1 Neighboring gene forkhead box J1 Neighboring gene ATP synthase membrane subunit g pseudogene 6 Neighboring gene activating transcription factor 4 pseudogene 3 Neighboring gene uncharacterized LOC105371896 Neighboring gene uncharacterized LOC107985019

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in endosome to lysosome transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of dendrite extension ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein autoubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin ligase RNF157
Names
RING-type E3 ubiquitin transferase RNF157
NP_001317430.1
NP_443148.1
XP_005257064.1
XP_011522575.1
XP_016879606.1
XP_016879609.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330501.2NP_001317430.1  E3 ubiquitin ligase RNF157 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AA609513, AB067504, AC015801, AK091467, BM310065, BM722923, BQ434552, CX872674
    Consensus CDS
    CCDS82208.1
    UniProtKB/Swiss-Prot
    Q96PX1
    Related
    ENSP00000321837.4, ENST00000319945.10
  2. NM_052916.3NP_443148.1  E3 ubiquitin ligase RNF157 isoform 1

    See identical proteins and their annotated locations for NP_443148.1

    Status: VALIDATED

    Source sequence(s)
    AA932192, AB067504, AC015801, AK055949, AK091467, BI857136, BM474134, CX872674
    Consensus CDS
    CCDS32740.1
    UniProtKB/Swiss-Prot
    Q96PX1
    Related
    ENSP00000269391.4, ENST00000269391.11
    Conserved Domains (1) summary
    pfam13920
    Location:276318
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    76142456..76240493 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257007.4XP_005257064.1  E3 ubiquitin ligase RNF157 isoform X2

    Conserved Domains (1) summary
    pfam13920
    Location:276318
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
  2. XM_017024117.2XP_016879606.1  E3 ubiquitin ligase RNF157 isoform X1

  3. XM_017024120.2XP_016879609.1  E3 ubiquitin ligase RNF157 isoform X3

  4. XM_011524273.3XP_011522575.1  E3 ubiquitin ligase RNF157 isoform X4

    Conserved Domains (1) summary
    pfam13920
    Location:276318
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

RNA

  1. XR_001752422.1 RNA Sequence

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