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RNF157 ring finger protein 157 [ Homo sapiens (human) ]

Gene ID: 114804, updated on 27-Nov-2024

Summary

Official Symbol
RNF157provided by HGNC
Official Full Name
ring finger protein 157provided by HGNC
Primary source
HGNC:HGNC:29402
See related
Ensembl:ENSG00000141576 AllianceGenome:HGNC:29402
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in negative regulation of apoptotic process; positive regulation of dendrite extension; and protein ubiquitination. Predicted to be located in cell body. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in brain (RPKM 16.0), testis (RPKM 13.4) and 11 other tissues See more
Orthologs
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Genomic context

See RNF157 in Genome Data Viewer
Location:
17q25.1
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (76142474..76240493, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (77039017..77137048, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (74138555..74236574, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928447 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9002 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74127821-74128482 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74128483-74129142 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74133109-74133770 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74133771-74134430 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74135093-74135752 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9003 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9004 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9005 Neighboring gene RNF157 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74140914-74141462 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74141463-74142010 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74143158-74143658 Neighboring gene forkhead box J1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:74162894-74164093 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74186853-74187352 Neighboring gene ATP synthase membrane subunit g pseudogene 6 Neighboring gene activating transcription factor 4 pseudogene 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74235542-74236214 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9006 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9007 Neighboring gene uncharacterized LOC105371896 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12794 Neighboring gene Sharpr-MPRA regulatory region 14042 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12795 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12796 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9008 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9009 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12797 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12798 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12799 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12800 Neighboring gene UBA like domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of dendrite extension ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
E3 ubiquitin ligase RNF157
Names
RING-type E3 ubiquitin transferase RNF157
NP_001317430.1
NP_443148.1
XP_011522575.1
XP_016879609.2
XP_047291242.1
XP_047291243.1
XP_047291244.1
XP_047291245.1
XP_054170911.1
XP_054170912.1
XP_054170913.1
XP_054170914.1
XP_054170915.1
XP_054170916.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330501.2NP_001317430.1  E3 ubiquitin ligase RNF157 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AA609513, AB067504, AC015801, AK091467, BM310065, BM722923, BQ434552, CX872674
    Consensus CDS
    CCDS82208.1
    UniProtKB/Swiss-Prot
    Q96PX1
    Related
    ENSP00000321837.4, ENST00000319945.10
  2. NM_052916.3NP_443148.1  E3 ubiquitin ligase RNF157 isoform 1

    See identical proteins and their annotated locations for NP_443148.1

    Status: VALIDATED

    Source sequence(s)
    AA932192, AB067504, AC015801, AK055949, AK091467, BI857136, BM474134, CX872674
    Consensus CDS
    CCDS32740.1
    UniProtKB/Swiss-Prot
    Q8NB72, Q96N56, Q96PX1
    Related
    ENSP00000269391.4, ENST00000269391.11
    Conserved Domains (1) summary
    pfam13920
    Location:276318
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    76142474..76240493 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047435287.1XP_047291243.1  E3 ubiquitin ligase RNF157 isoform X2

  2. XM_047435286.1XP_047291242.1  E3 ubiquitin ligase RNF157 isoform X1

    UniProtKB/TrEMBL
    A0A3B3ISM3
    Related
    ENSP00000497353.1, ENST00000647930.1
  3. XM_047435288.1XP_047291244.1  E3 ubiquitin ligase RNF157 isoform X3

  4. XM_017024120.3XP_016879609.2  E3 ubiquitin ligase RNF157 isoform X4

  5. XM_011524273.4XP_011522575.1  E3 ubiquitin ligase RNF157 isoform X6

    Conserved Domains (1) summary
    pfam13920
    Location:276318
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
  6. XM_047435289.1XP_047291245.1  E3 ubiquitin ligase RNF157 isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    77039017..77137048 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054314937.1XP_054170912.1  E3 ubiquitin ligase RNF157 isoform X2

  2. XM_054314936.1XP_054170911.1  E3 ubiquitin ligase RNF157 isoform X1

  3. XM_054314938.1XP_054170913.1  E3 ubiquitin ligase RNF157 isoform X3

  4. XM_054314939.1XP_054170914.1  E3 ubiquitin ligase RNF157 isoform X4

  5. XM_054314941.1XP_054170916.1  E3 ubiquitin ligase RNF157 isoform X6

  6. XM_054314940.1XP_054170915.1  E3 ubiquitin ligase RNF157 isoform X5