Format

Send to:

Choose Destination

ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 [ Homo sapiens (human) ]

Gene ID: 114799, updated on 9-Feb-2020

Summary

Official Symbol
ESCO1provided by HGNC
Official Full Name
establishment of sister chromatid cohesion N-acetyltransferase 1provided by HGNC
Primary source
HGNC:HGNC:24645
See related
Ensembl:ENSG00000141446 MIM:609674
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CTF; ECO1; EFO1; ESO1; A930014I12Rik
Summary
ESCO1 belongs to a conserved family of acetyltransferases involved in sister chromatid cohesion (Hou and Zou, 2005 [PubMed 15958495]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in testis (RPKM 14.5), bone marrow (RPKM 6.3) and 25 other tissues See more
Orthologs

Genomic context

See ESCO1 in Genome Data Viewer
Location:
18q11.2
Exon count:
13
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (21529281..21600736, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (19109242..19180697, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927496 Neighboring gene GREB1 like retinoic acid receptor coactivator Neighboring gene uncharacterized LOC101927521 Neighboring gene small nuclear ribonucleoprotein D1 polypeptide Neighboring gene abhydrolase domain containing 3, phospholipase Neighboring gene microRNA 320c-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1911, MGC105022

Gene Ontology Provided by GOA

Function Evidence Code Pubs
N-acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
peptide-lysine-N-acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
peptidyl-lysine acetylation IDA
Inferred from Direct Assay
more info
PubMed 
post-translational protein acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
post-translational protein acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
sister chromatid cohesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
chromatin IDA
Inferred from Direct Assay
more info
PubMed 
chromosome IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
N-acetyltransferase ESCO1
Names
CTF7 homolog 1
ECO1 homolog 1
EFO1p
ESO1 homolog 1
N-acetyltransferase ESCO1 variant 2
establishment factor-like protein 1
establishment of cohesion 1 homolog 1
hEFO1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052911.3NP_443143.2  N-acetyltransferase ESCO1

    See identical proteins and their annotated locations for NP_443143.2

    Status: VALIDATED

    Source sequence(s)
    AB067498, AC011774, AK096746, BC089426, BG492713
    Consensus CDS
    CCDS32800.1
    UniProtKB/Swiss-Prot
    Q5FWF5
    UniProtKB/TrEMBL
    A0A024RC19
    Related
    ENSP00000269214.4, ENST00000269214.10
    Conserved Domains (2) summary
    pfam13878
    Location:604643
    zf-C2H2_3; zinc-finger of acetyl-transferase ESCO
    pfam13880
    Location:763825
    Acetyltransf_13; ESCO1/2 acetyl-transferase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    21529281..21600736 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525799.3XP_011524101.1  N-acetyltransferase ESCO1 isoform X2

    Conserved Domains (2) summary
    pfam13878
    Location:604643
    zf-C2H2_3; zinc-finger of acetyl-transferase ESCO
    pfam13880
    Location:733795
    Acetyltransf_13; ESCO1/2 acetyl-transferase
  2. XM_011525798.1XP_011524100.1  N-acetyltransferase ESCO1 isoform X1

    See identical proteins and their annotated locations for XP_011524100.1

    UniProtKB/Swiss-Prot
    Q5FWF5
    UniProtKB/TrEMBL
    A0A024RC19
    Conserved Domains (2) summary
    pfam13878
    Location:604643
    zf-C2H2_3; zinc-finger of acetyl-transferase ESCO
    pfam13880
    Location:763825
    Acetyltransf_13; ESCO1/2 acetyl-transferase

RNA

  1. XR_001753137.2 RNA Sequence

    Related
    ENST00000383276.1
  2. XR_001753138.1 RNA Sequence

Support Center