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FMNL2 formin like 2 [ Homo sapiens (human) ]

Gene ID: 114793, updated on 7-Jun-2020

Summary

Official Symbol
FMNL2provided by HGNC
Official Full Name
formin like 2provided by HGNC
Primary source
HGNC:HGNC:18267
See related
Ensembl:ENSG00000157827 MIM:616285
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FHOD2
Summary
This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. Alternatively spliced transcript variants encoding different isoforms have been described but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]
Expression
Broad expression in brain (RPKM 47.7), placenta (RPKM 25.7) and 20 other tissues See more
Orthologs

Genomic context

See FMNL2 in Genome Data Viewer
Location:
2q23.3
Exon count:
30
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (152335170..152649826)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (153191684..153506348)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373689 Neighboring gene uncharacterized LOC105373688 Neighboring gene ribosomal protein L30 pseudogene 2 Neighboring gene signal transducing adaptor molecule 2 Neighboring gene Sharpr-MPRA regulatory region 2662 Neighboring gene nuclear distribution C pseudogene 1 Neighboring gene uncharacterized LOC105373690 Neighboring gene pre-mRNA processing factor 40 homolog A Neighboring gene ADP ribosylation factor like GTPase 6 interacting protein 6 Neighboring gene ubiquilin 4 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37546

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Rho GTPase binding IEA
Inferred from Electronic Annotation
more info
 
actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cadherin binding HDA PubMed 
Process Evidence Code Pubs
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cortical actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cortical actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
formin-like protein 2
Names
formin homology 2 domain containing 2
formin homology 2 domain-containing protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052905.4NP_443137.2  formin-like protein 2

    See identical proteins and their annotated locations for NP_443137.2

    Status: REVIEWED

    Source sequence(s)
    AB067489, AC012066, AC012443, AC093794
    Consensus CDS
    CCDS46429.1
    UniProtKB/Swiss-Prot
    Q96PY5
    Related
    ENSP00000288670.9, ENST00000288670.14
    Conserved Domains (3) summary
    pfam02181
    Location:616967
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:278475
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:23275
    Drf_GBD; Diaphanous GTPase-binding Domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    152335170..152649826
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510532.3XP_011508834.1  formin-like protein 2 isoform X3

    Conserved Domains (3) summary
    pfam02181
    Location:623974
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:278475
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:23275
    Drf_GBD; Diaphanous GTPase-binding Domain
  2. XM_011510531.1XP_011508833.1  formin-like protein 2 isoform X2

    Conserved Domains (3) summary
    pfam02181
    Location:623974
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:278475
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:23275
    Drf_GBD; Diaphanous GTPase-binding Domain
  3. XM_011510533.3XP_011508835.1  formin-like protein 2 isoform X4

    Conserved Domains (3) summary
    pfam02181
    Location:623974
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:278475
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:23275
    Drf_GBD; Diaphanous GTPase-binding Domain
  4. XM_011510530.1XP_011508832.1  formin-like protein 2 isoform X1

    Conserved Domains (3) summary
    pfam02181
    Location:623974
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:278475
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:23275
    Drf_GBD; Diaphanous GTPase-binding Domain
  5. XM_011510534.1XP_011508836.1  formin-like protein 2 isoform X7

    Conserved Domains (3) summary
    pfam02181
    Location:623951
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:278475
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:23275
    Drf_GBD; Diaphanous GTPase-binding Domain
  6. XM_005246263.2XP_005246320.1  formin-like protein 2 isoform X5

    See identical proteins and their annotated locations for XP_005246320.1

    Conserved Domains (3) summary
    pfam02181
    Location:616967
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:278475
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:23275
    Drf_GBD; Diaphanous GTPase-binding Domain
  7. XM_011510535.2XP_011508837.1  formin-like protein 2 isoform X8

    Conserved Domains (3) summary
    pfam02181
    Location:572923
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:227424
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:23224
    Drf_GBD; Diaphanous GTPase-binding Domain
  8. XM_005246265.3XP_005246322.1  formin-like protein 2 isoform X6

    See identical proteins and their annotated locations for XP_005246322.1

    Conserved Domains (3) summary
    pfam02181
    Location:616967
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:278475
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:23275
    Drf_GBD; Diaphanous GTPase-binding Domain
  9. XM_011510536.3XP_011508838.1  formin-like protein 2 isoform X9

    Conserved Domains (3) summary
    pfam02181
    Location:384735
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:39236
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:236
    Drf_GBD; Diaphanous GTPase-binding Domain

RNA

  1. XR_241279.4 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001004417.1: Suppressed sequence

    Description
    NM_001004417.1: This RefSeq was temporarily suppressed because currently there is insufficient data to support this transcript.
  2. NM_001004421.1: Suppressed sequence

    Description
    NM_001004421.1: This RefSeq was temporarily suppressed because currently there is insufficient data to support this transcript.
  3. NM_001004422.1: Suppressed sequence

    Description
    NM_001004422.1: This RefSeq was temporarily suppressed because currently there is insufficient data to support this transcript.
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