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TUBGCP5 tubulin gamma complex associated protein 5 [ Homo sapiens (human) ]

Gene ID: 114791, updated on 5-Aug-2022

Summary

Official Symbol
TUBGCP5provided by HGNC
Official Full Name
tubulin gamma complex associated protein 5provided by HGNC
Primary source
HGNC:HGNC:18600
See related
Ensembl:ENSG00000275835 MIM:608147; AllianceGenome:HGNC:18600
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GCP5
Summary
Enables microtubule binding activity. Involved in microtubule nucleation. Located in centrosome and cytosol. Part of gamma-tubulin large complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 5.8), brain (RPKM 3.5) and 25 other tissues See more
Orthologs
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Genomic context

See TUBGCP5 in Genome Data Viewer
Location:
15q11.2
Exon count:
27
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (22983025..23039569, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (20654893..20711463, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (22833499..22890043)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene NIPA magnesium transporter 2 Neighboring gene Sharpr-MPRA regulatory region 8478 Neighboring gene cytoplasmic FMR1 interacting protein 1 Neighboring gene engulfment and cell motility 2 pseudogene 1 Neighboring gene WAS/WASL-interacting protein family member 3-like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1899

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables gamma-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to microtubule minus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in microtubule nucleation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in microtubule nucleation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in equatorial microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of gamma-tubulin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of gamma-tubulin ring complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
gamma-tubulin complex component 5
Names
gamma-tubulin complex component GCP5

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102610.2NP_001096080.1  gamma-tubulin complex component 5 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site at its 3' terminal exon, compared to variant 1, and encodes isoform b. Isoforms a and b are identical in length but differ in their C-termini.
    Source sequence(s)
    AB067486, AC116166, AK056416
    Consensus CDS
    CCDS73697.1
    UniProtKB/Swiss-Prot
    Q96RT8
    Related
    ENSP00000481853.1, ENST00000620435.4
    Conserved Domains (1) summary
    pfam04130
    Location:273942
    Spc97_Spc98; Spc97 / Spc98 family
  2. NM_001354372.2NP_001341301.1  gamma-tubulin complex component 5 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC090764, AC116166
    Conserved Domains (1) summary
    pfam04130
    Location:274943
    Spc97_Spc98; Spc97 / Spc98 family
  3. NM_001354373.2NP_001341302.1  gamma-tubulin complex component 5 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC090764, AC116166
    Related
    ENSP00000484566.1, ENST00000614508.4
    Conserved Domains (1) summary
    pfam04130
    Location:273942
    Spc97_Spc98; Spc97 / Spc98 family
  4. NM_001354374.2NP_001341303.1  gamma-tubulin complex component 5 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC090764, AC116166
    Conserved Domains (1) summary
    pfam04130
    Location:273928
    Spc97_Spc98; Spc97 / Spc98 family
  5. NM_001354375.2NP_001341304.1  gamma-tubulin complex component 5 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC090764, AC116166
    Conserved Domains (1) summary
    pfam04130
    Location:273942
    Spc97_Spc98; Spc97 / Spc98 family
  6. NM_001354376.2NP_001341305.1  gamma-tubulin complex component 5 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC090764, AC116166
    Conserved Domains (1) summary
    pfam04130
    Location:273942
    Spc97_Spc98; Spc97 / Spc98 family
  7. NM_001354377.2NP_001341306.1  gamma-tubulin complex component 5 isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) uses an alternate splice sites compared to variant 1, and encodes isoform h. Isoforms h and i are identical in length but differ in their C-termini.
    Source sequence(s)
    AC116166
    Conserved Domains (1) summary
    pfam04130
    Location:274943
    Spc97_Spc98; Spc97 / Spc98 family
  8. NM_001354378.2NP_001341307.1  gamma-tubulin complex component 5 isoform i

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) uses an alternate splice sites compared to variant 1, and encodes isoform i. Isoforms h and i are identical in length but differ in their C-termini.
    Source sequence(s)
    AC116166
    Conserved Domains (1) summary
    pfam04130
    Location:274943
    Spc97_Spc98; Spc97 / Spc98 family
  9. NM_052903.6NP_443135.3  gamma-tubulin complex component 5 isoform a

    See identical proteins and their annotated locations for NP_443135.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a. Isoforms a and b are identical in length but differ in their C-termini.
    Source sequence(s)
    AB067486, BC071560
    Consensus CDS
    CCDS73698.1
    UniProtKB/Swiss-Prot
    Q96PY8, Q96RT8
    Related
    ENSP00000480316.1, ENST00000615383.5
    Conserved Domains (2) summary
    pfam04130
    Location:7161017
    Spc97_Spc98; Spc97 / Spc98 family
    pfam17681
    Location:271577
    GCP_N_terminal; Gamma tubulin complex component N-terminal

RNA

  1. NR_148875.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC090764, AC116166

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    22983025..23039569 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432130.1XP_047288086.1  gamma-tubulin complex component 5 isoform X3

  2. XM_017021895.2XP_016877384.1  gamma-tubulin complex component 5 isoform X4

  3. XM_017021894.2XP_016877383.1  gamma-tubulin complex component 5 isoform X3

  4. XM_017021896.2XP_016877385.1  gamma-tubulin complex component 5 isoform X6

  5. XM_017021901.2XP_016877390.1  gamma-tubulin complex component 5 isoform X7

  6. XM_011543870.3XP_011542172.1  gamma-tubulin complex component 5 isoform X2

    Conserved Domains (1) summary
    pfam04130
    Location:274943
    Spc97_Spc98; Spc97 / Spc98 family
  7. XM_011543868.3XP_011542170.1  gamma-tubulin complex component 5 isoform X1

    Conserved Domains (1) summary
    pfam04130
    Location:274943
    Spc97_Spc98; Spc97 / Spc98 family
  8. XM_047432131.1XP_047288087.1  gamma-tubulin complex component 5 isoform X5

RNA

  1. XR_007064420.1 RNA Sequence

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_021160017.1 Reference GRCh38.p14 PATCHES

    Range
    3877112..3933660 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187603.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    80019..136590 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_187659.1 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    1543..4302 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    20654893..20711463 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)