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TUBGCP5 tubulin gamma complex associated protein 5 [ Homo sapiens (human) ]

Gene ID: 114791, updated on 10-Jul-2019

Summary

Official Symbol
TUBGCP5provided by HGNC
Official Full Name
tubulin gamma complex associated protein 5provided by HGNC
Primary source
HGNC:HGNC:18600
See related
Ensembl:ENSG00000275835 MIM:608147
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GCP5
Expression
Ubiquitous expression in testis (RPKM 5.8), brain (RPKM 3.5) and 25 other tissues See more
Orthologs

Genomic context

See TUBGCP5 in Genome Data Viewer
Location:
15q11.2
Exon count:
28
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (22983025..23039673, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (22833395..22873891)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene NIPA magnesium transporter 2 Neighboring gene Sharpr-MPRA regulatory region 8478 Neighboring gene cytoplasmic FMR1 interacting protein 1 Neighboring gene engulfment and cell motility 2 pseudogene 1 Neighboring gene pectinesterase inhibitor 10-like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • Centrosome maturation, organism-specific biosystem (from REACTOME)
    Centrosome maturation, organism-specific biosystemThe centrosome is the primary microtubule organizing center (MTOC) in vertebrate cells and plays an important role in orchestrating the formation of the mitotic spindle. Centrosome maturation is an ...
  • G2/M Transition, organism-specific biosystem (from REACTOME)
    G2/M Transition, organism-specific biosystemCyclin A can also form complexes with Cdc2 (Cdk1). Together with three B-type cyclins, Cdc2 (Cdk1) regulates the transition from G2 into mitosis. These complexes are activated by dephosphorylation of...
  • Mitotic G2-G2/M phases, organism-specific biosystem (from REACTOME)
    Mitotic G2-G2/M phases, organism-specific biosystem
    Mitotic G2-G2/M phases
  • Recruitment of NuMA to mitotic centrosomes, organism-specific biosystem (from REACTOME)
    Recruitment of NuMA to mitotic centrosomes, organism-specific biosystemThe NuMA protein, which functions as a nuclear matrix protein in interphase (Merdes and Cleveland 1998), redistributes to the cytoplasm following nuclear envelope breakdown where it plays an essen...
  • Recruitment of mitotic centrosome proteins and complexes, organism-specific biosystem (from REACTOME)
    Recruitment of mitotic centrosome proteins and complexes, organism-specific biosystemThe mitotic spindle becomes established once centrosomes have migrated to opposite poles and the nuclear envelope has broken down. During this stage, interphase centrosomes mature into mitotic centro...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1899

Gene Ontology Provided by GOA

Function Evidence Code Pubs
gamma-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to microtubule minus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule nucleation IDA
Inferred from Direct Assay
more info
PubMed 
microtubule nucleation by interphase microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
equatorial microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
gamma-tubulin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
gamma-tubulin ring complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
gamma-tubulin ring complex IDA
Inferred from Direct Assay
more info
PubMed 
microtubule IEA
Inferred from Electronic Annotation
more info
 
spindle pole IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
gamma-tubulin complex component 5
Names
gamma-tubulin complex component GCP5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102610.1NP_001096080.1  gamma-tubulin complex component 5 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site at its 3' terminal exon, compared to variant 1, and encodes isoform b. Isoforms a and b are identical in length but differ in their C-termini.
    Source sequence(s)
    AB067486, AK056416, BP362649
    Consensus CDS
    CCDS73697.1
    UniProtKB/Swiss-Prot
    Q96RT8
    Related
    ENSP00000481853.1, ENST00000620435.4
    Conserved Domains (1) summary
    pfam04130
    Location:273942
    Spc97_Spc98; Spc97 / Spc98 family
  2. NM_001354372.2NP_001341301.1  gamma-tubulin complex component 5 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC090764, AC116166
    Conserved Domains (1) summary
    pfam04130
    Location:274943
    Spc97_Spc98; Spc97 / Spc98 family
  3. NM_001354373.2NP_001341302.1  gamma-tubulin complex component 5 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC090764, AC116166
    Related
    ENSP00000484566.1, ENST00000614508.4
    Conserved Domains (1) summary
    pfam04130
    Location:273942
    Spc97_Spc98; Spc97 / Spc98 family
  4. NM_001354374.2NP_001341303.1  gamma-tubulin complex component 5 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC090764, AC116166
    Conserved Domains (1) summary
    pfam04130
    Location:273928
    Spc97_Spc98; Spc97 / Spc98 family
  5. NM_001354375.2NP_001341304.1  gamma-tubulin complex component 5 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC090764, AC116166
    Conserved Domains (1) summary
    pfam04130
    Location:273942
    Spc97_Spc98; Spc97 / Spc98 family
  6. NM_001354376.2NP_001341305.1  gamma-tubulin complex component 5 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC090764, AC116166
    Conserved Domains (1) summary
    pfam04130
    Location:273942
    Spc97_Spc98; Spc97 / Spc98 family
  7. NM_001354377.1NP_001341306.1  gamma-tubulin complex component 5 isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) uses an alternate splice sites compared to variant 1, and encodes isoform h. Isoforms h and i are identical in length but differ in their C-termini.
    Source sequence(s)
    AC116166
    Conserved Domains (1) summary
    pfam04130
    Location:274943
    Spc97_Spc98; Spc97 / Spc98 family
  8. NM_001354378.1NP_001341307.1  gamma-tubulin complex component 5 isoform i

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) uses an alternate splice sites compared to variant 1, and encodes isoform i. Isoforms h and i are identical in length but differ in their C-termini.
    Source sequence(s)
    AC116166
    Conserved Domains (1) summary
    pfam04130
    Location:274943
    Spc97_Spc98; Spc97 / Spc98 family
  9. NM_052903.6NP_443135.3  gamma-tubulin complex component 5 isoform a

    See identical proteins and their annotated locations for NP_443135.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a. Isoforms a and b are identical in length but differ in their C-termini.
    Source sequence(s)
    AB067486, BC071560
    Consensus CDS
    CCDS73698.1
    UniProtKB/Swiss-Prot
    Q96RT8
    Related
    ENSP00000480316.1, ENST00000615383.5
    Conserved Domains (1) summary
    pfam04130
    Location:273942
    Spc97_Spc98; Spc97 / Spc98 family

RNA

  1. NR_148875.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC090764, AC116166

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    22983025..23039673 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021895.1XP_016877384.1  gamma-tubulin complex component 5 isoform X5

  2. XM_017021899.2XP_016877388.1  gamma-tubulin complex component 5 isoform X8

  3. XM_017021900.1XP_016877389.1  gamma-tubulin complex component 5 isoform X8

  4. XM_017021894.1XP_016877383.1  gamma-tubulin complex component 5 isoform X4

  5. XM_017021898.1XP_016877387.1  gamma-tubulin complex component 5 isoform X8

  6. XM_017021896.1XP_016877385.1  gamma-tubulin complex component 5 isoform X6

  7. XM_017021901.1XP_016877390.1  gamma-tubulin complex component 5 isoform X8

  8. XM_017021897.2XP_016877386.1  gamma-tubulin complex component 5 isoform X7

  9. XM_011543870.2XP_011542172.1  gamma-tubulin complex component 5 isoform X2

    Conserved Domains (1) summary
    pfam04130
    Location:274943
    Spc97_Spc98; Spc97 / Spc98 family
  10. XM_011543868.2XP_011542170.1  gamma-tubulin complex component 5 isoform X1

    Conserved Domains (1) summary
    pfam04130
    Location:274943
    Spc97_Spc98; Spc97 / Spc98 family
  11. XM_017021893.2XP_016877382.1  gamma-tubulin complex component 5 isoform X3

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_021160017.1 Reference GRCh38.p13 PATCHES

    Range
    3877112..3933764 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187603.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    80019..136694 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_2

Genomic

  1. NT_187659.1 Reference GRCh38.p13 ALT_REF_LOCI_2

    Range
    1543..4406 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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