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SLC25A25 solute carrier family 25 member 25 [ Homo sapiens (human) ]

Gene ID: 114789, updated on 1-Jun-2020

Summary

Official Symbol
SLC25A25provided by HGNC
Official Full Name
solute carrier family 25 member 25provided by HGNC
Primary source
HGNC:HGNC:20663
See related
Ensembl:ENSG00000148339 MIM:608745
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCSC; PCSCL; SCAMC-2
Summary
The protein encoded by this gene belongs to the family of calcium-binding mitochondrial carriers, with a characteristic mitochondrial carrier domain at the C-terminus. These proteins are found in the inner membranes of mitochondria, and function as transport proteins. They shuttle metabolites, nucleotides and cofactors through the mitochondrial membrane and thereby connect and/or regulate cytoplasm and matrix functions. This protein may function as an ATP-Mg/Pi carrier that mediates the transport of Mg-ATP in exchange for phosphate, and likely responsible for the net uptake or efflux of adenine nucleotides into or from the mitochondria. Alternatively spliced transcript variants encoding different isoforms with a common C-terminus but variable N-termini have been described for this gene. [provided by RefSeq, Jul 2012]
Expression
Ubiquitous expression in liver (RPKM 17.5), gall bladder (RPKM 17.0) and 25 other tissues See more
Orthologs

Genomic context

See SLC25A25 in Genome Data Viewer
Location:
9q34.11
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (128068200..128109258)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (130830479..130871537)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 5179 Neighboring gene nuclear apoptosis inducing factor 1 Neighboring gene SLC25A25 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 4689 Neighboring gene prostaglandin E synthase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1896, MGC105138, MGC119514, MGC119515, MGC119516, MGC119517

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
ATP metabolic process IEA
Inferred from Electronic Annotation
more info
 
ATP transport IEA
Inferred from Electronic Annotation
more info
 
adipose tissue development IEA
Inferred from Electronic Annotation
more info
 
calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
camera-type eye development IEA
Inferred from Electronic Annotation
more info
 
cellular respiration IEA
Inferred from Electronic Annotation
more info
 
multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
response to activity IEA
Inferred from Electronic Annotation
more info
 
response to dietary excess IEA
Inferred from Electronic Annotation
more info
 
response to food IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
calcium-binding mitochondrial carrier protein SCaMC-2
Names
mitochondrial ATP-Mg/Pi carrier protein 3
mitochondrial Ca(2+)-dependent solute carrier protein 3
short calcium-binding mitochondrial carrier 2
small calcium-binding mitochondrial carrier 2
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032871.1 RefSeqGene

    Range
    5001..46059
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001006641.3NP_001006642.1  calcium-binding mitochondrial carrier protein SCaMC-2 isoform b

    See identical proteins and their annotated locations for NP_001006642.1

    Status: REVIEWED

    Source sequence(s)
    AJ619990, AK290991, BM689843
    Consensus CDS
    CCDS35151.1
    UniProtKB/Swiss-Prot
    Q6KCM7
    Related
    ENSP00000362159.2, ENST00000373068.6
    Conserved Domains (3) summary
    cd00051
    Location:116175
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00153
    Location:310402
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:52110
    EF-hand_7; EF-hand domain pair
  2. NM_001006642.3NP_001006643.1  calcium-binding mitochondrial carrier protein SCaMC-2 isoform c precursor

    See identical proteins and their annotated locations for NP_001006643.1

    Status: REVIEWED

    Source sequence(s)
    AB067483, AJ619991, AL360268, BM689843, DA219774
    Consensus CDS
    CCDS48031.1
    UniProtKB/Swiss-Prot
    Q6KCM7
    Related
    ENSP00000410053.2, ENST00000432073.6
    Conserved Domains (4) summary
    cd00051
    Location:102161
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00153
    Location:296388
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:103158
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:6397
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  3. NM_001265614.2NP_001252543.1  calcium-binding mitochondrial carrier protein SCaMC-2 isoform 5 precursor

    See identical proteins and their annotated locations for NP_001252543.1

    Status: REVIEWED

    Source sequence(s)
    AB067483, AJ619990, AL360268, BM689843, DA219774
    Consensus CDS
    CCDS59146.1
    UniProtKB/Swiss-Prot
    Q6KCM7
    Related
    ENSP00000362157.5, ENST00000373066.9
    Conserved Domains (4) summary
    cd00051
    Location:102173
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00153
    Location:308400
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:103170
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:6397
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  4. NM_001330988.1NP_001317917.1  calcium-binding mitochondrial carrier protein SCaMC-2 isoform e

    Status: REVIEWED

    Source sequence(s)
    AB067483, AJ619989, BC036889, BC061925, DA713306
    Consensus CDS
    CCDS83420.1
    UniProtKB/Swiss-Prot
    Q6KCM7
    Related
    ENSP00000362160.5, ENST00000373069.9
  5. NM_052901.4NP_443133.2  calcium-binding mitochondrial carrier protein SCaMC-2 isoform a

    See identical proteins and their annotated locations for NP_443133.2

    Status: REVIEWED

    Source sequence(s)
    AJ619990, BC089448, BM689843, BQ637100
    Consensus CDS
    CCDS6890.1
    UniProtKB/Swiss-Prot
    Q6KCM7
    Related
    ENSP00000362155.5, ENST00000373064.9
    Conserved Domains (3) summary
    cd15897
    Location:5377
    EFh_PEF; EF-hand motif [structural motif]
    cl25352
    Location:53139
    EFh_PEF; The penta-EF hand (PEF) family
    cl28162
    Location:191445
    Mito_carr; Mitochondrial carrier protein

RNA

  1. NR_049766.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AJ619990, AJ619992, AL360268, BM689843, BQ637100

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    128068200..128109258
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006716948.3XP_006717011.1  calcium-binding mitochondrial carrier protein SCaMC-2 isoform X1

    See identical proteins and their annotated locations for XP_006717011.1

    Conserved Domains (4) summary
    cd00051
    Location:82153
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00153
    Location:288380
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:83150
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:2977
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  2. XM_006716949.3XP_006717012.1  calcium-binding mitochondrial carrier protein SCaMC-2 isoform X2

    Conserved Domains (1) summary
    pfam00153
    Location:185277
    Mito_carr; Mitochondrial carrier protein

RNA

  1. XR_002956752.1 RNA Sequence

  2. XR_002956753.1 RNA Sequence

  3. XR_002956754.1 RNA Sequence

  4. XR_002956755.1 RNA Sequence

  5. XR_002956756.1 RNA Sequence

  6. XR_002956757.1 RNA Sequence

  7. XR_002956758.1 RNA Sequence

  8. XR_002956759.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001006643.1: Suppressed sequence

    Description
    NM_001006643.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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