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SLC25A25 solute carrier family 25 member 25 [ Homo sapiens (human) ]

Gene ID: 114789, updated on 27-Nov-2024

Summary

Official Symbol
SLC25A25provided by HGNC
Official Full Name
solute carrier family 25 member 25provided by HGNC
Primary source
HGNC:HGNC:20663
See related
Ensembl:ENSG00000148339 MIM:608745; AllianceGenome:HGNC:20663
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCSC; PCSCL; SCAMC2; SCAMC-2
Summary
The protein encoded by this gene belongs to the family of calcium-binding mitochondrial carriers, with a characteristic mitochondrial carrier domain at the C-terminus. These proteins are found in the inner membranes of mitochondria, and function as transport proteins. They shuttle metabolites, nucleotides and cofactors through the mitochondrial membrane and thereby connect and/or regulate cytoplasm and matrix functions. This protein may function as an ATP-Mg/Pi carrier that mediates the transport of Mg-ATP in exchange for phosphate, and likely responsible for the net uptake or efflux of adenine nucleotides into or from the mitochondria. Alternatively spliced transcript variants encoding different isoforms with a common C-terminus but variable N-termini have been described for this gene. [provided by RefSeq, Jul 2012]
Expression
Ubiquitous expression in liver (RPKM 17.5), gall bladder (RPKM 17.0) and 25 other tissues See more
Orthologs
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Genomic context

See SLC25A25 in Genome Data Viewer
Location:
9q34.11
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (128068232..128109245)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (140276208..140317210)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (130830511..130871524)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902280 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130704889-130705418 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130708322-130708822 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130708823-130709323 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130717798-130718764 Neighboring gene estrogen-induced osteoclastogenesis regulator 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130723095-130723703 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130723748-130724584 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130724585-130725420 Neighboring gene Sharpr-MPRA regulatory region 6856 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130730939-130731467 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130735756-130736498 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130736499-130737242 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29063 Neighboring gene conserved acetylation island sequence 15 enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20319 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29064 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130763335-130763870 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130763871-130764404 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29065 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29066 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29067 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20321 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20320 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29068 Neighboring gene Sharpr-MPRA regulatory region 5179 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130817345-130818242 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29069 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20323 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29070 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:130835790-130836290 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:130836291-130836791 Neighboring gene nuclear apoptosis inducing factor 1 Neighboring gene Sharpr-MPRA regulatory region 4771 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130853709-130854229 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:130854230-130854750 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130859824-130860560 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130860561-130861298 Neighboring gene SLC25A25 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 4689 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29071 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29072 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20324 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29073 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20325 Neighboring gene prostaglandin E synthase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA1896, MGC105138, MGC119514, MGC119515, MGC119516, MGC119517

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATP:phosphate antiporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in ADP transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ATP metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in ATP transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in adipose tissue development IEA
Inferred from Electronic Annotation
more info
 
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in camera-type eye development IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular respiration IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
involved_in response to activity IEA
Inferred from Electronic Annotation
more info
 
involved_in response to dietary excess IEA
Inferred from Electronic Annotation
more info
 
involved_in response to food IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HTP PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mitochondrial adenyl nucleotide antiporter SLC25A25
Names
calcium-binding mitochondrial carrier protein SCaMC-2
mitochondrial ATP-Mg/Pi carrier protein 3
mitochondrial Ca(2+)-dependent solute carrier protein 3
short calcium-binding mitochondrial carrier 2
short calcium-binding mitochondrial carrier protein 2
small calcium-binding mitochondrial carrier 2
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032871.2 RefSeqGene

    Range
    5002..46015
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001006641.4NP_001006642.1  mitochondrial adenyl nucleotide antiporter SLC25A25 isoform b

    See identical proteins and their annotated locations for NP_001006642.1

    Status: REVIEWED

    Source sequence(s)
    AL360268, AL590708
    Consensus CDS
    CCDS35151.1
    UniProtKB/Swiss-Prot
    Q6KCM7
    Related
    ENSP00000362159.2, ENST00000373068.6
    Conserved Domains (3) summary
    cd00051
    Location:116175
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00153
    Location:310402
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:52110
    EF-hand_7; EF-hand domain pair
  2. NM_001006642.4NP_001006643.1  mitochondrial adenyl nucleotide antiporter SLC25A25 isoform c precursor

    See identical proteins and their annotated locations for NP_001006643.1

    Status: REVIEWED

    Source sequence(s)
    AL360268, AL590708
    Consensus CDS
    CCDS48031.1
    UniProtKB/TrEMBL
    A0A804HLB0
    Related
    ENSP00000410053.2, ENST00000432073.6
    Conserved Domains (4) summary
    cd00051
    Location:102161
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00153
    Location:296388
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:103158
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:6397
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  3. NM_001265614.3NP_001252543.1  mitochondrial adenyl nucleotide antiporter SLC25A25 isoform 5 precursor

    See identical proteins and their annotated locations for NP_001252543.1

    Status: REVIEWED

    Source sequence(s)
    AL360268, AL590708
    Consensus CDS
    CCDS59146.1
    UniProtKB/TrEMBL
    A0A804HLB0
    Related
    ENSP00000362157.5, ENST00000373066.9
    Conserved Domains (4) summary
    cd00051
    Location:102173
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00153
    Location:308400
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:103170
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:6397
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  4. NM_001330988.2NP_001317917.1  mitochondrial adenyl nucleotide antiporter SLC25A25 isoform e

    Status: REVIEWED

    Source sequence(s)
    AL360268, AL590708
    Consensus CDS
    CCDS83420.1
    UniProtKB/Swiss-Prot
    Q6KCM7
    Related
    ENSP00000362160.5, ENST00000373069.10
  5. NM_001387057.1NP_001373986.1  mitochondrial adenyl nucleotide antiporter SLC25A25 isoform f

    Status: REVIEWED

    Source sequence(s)
    AL360268, AL590708
    Conserved Domains (5) summary
    PTZ00169
    Location:203457
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    cd15898
    Location:82111
    EFh_PI-PLC; EF-hand motif [structural motif]
    cd15897
    Location:5377
    EFh_PEF; EF-hand motif [structural motif]
    cl28895
    Location:82171
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    cl25352
    Location:53125
    EFh_PEF; The penta-EF hand (PEF) family
  6. NM_052901.5NP_443133.2  mitochondrial adenyl nucleotide antiporter SLC25A25 isoform a

    See identical proteins and their annotated locations for NP_443133.2

    Status: REVIEWED

    Source sequence(s)
    AL360268, AL590708
    Consensus CDS
    CCDS6890.1
    UniProtKB/Swiss-Prot
    Q5SYW7, Q5SYW8, Q5SYX3, Q5VWU2, Q5VWU3, Q5VWU4, Q6KCM4, Q6KCM6, Q6KCM7, Q6UX48, Q705K2, Q96PZ1, Q9BSA6
    Related
    ENSP00000362155.5, ENST00000373064.9
    Conserved Domains (3) summary
    cd15897
    Location:5377
    EFh_PEF; EF-hand motif [structural motif]
    cl25352
    Location:53139
    EFh_PEF; The penta-EF hand (PEF) family
    cl28162
    Location:191445
    Mito_carr; Mitochondrial carrier protein

RNA

  1. NR_049766.3 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL360268, AL590708
    Related
    ENST00000683206.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    128068232..128109245
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    140276208..140317210
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001006643.1: Suppressed sequence

    Description
    NM_001006643.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.