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Pawr PRKC, apoptosis, WT1, regulator [ Mus musculus (house mouse) ]

Gene ID: 114774, updated on 4-Dec-2022

Summary

Official Symbol
Pawrprovided by MGI
Official Full Name
PRKC, apoptosis, WT1, regulatorprovided by MGI
Primary source
MGI:MGI:2149961
See related
Ensembl:ENSMUSG00000035873 AllianceGenome:MGI:2149961
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PAR4; Par-4; 2310001G03Rik
Summary
Predicted to enable actin binding activity; enzyme binding activity; and leucine zipper domain binding activity. Involved in negative regulation of fibroblast proliferation; regulation of cellular response to stress; and regulation of gene expression. Acts upstream of or within several processes, including negative regulation of T cell receptor signaling pathway; negative regulation of lymphocyte proliferation; and positive regulation of amyloid precursor protein biosynthetic process. Located in chromatin; cytoplasm; and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human PAWR (pro-apoptotic WT1 regulator). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 25.5), colon adult (RPKM 22.1) and 21 other tissues See more
Orthologs
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Genomic context

See Pawr in Genome Data Viewer
Location:
10; 10 D1
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (108168050..108250708)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (108332189..108414391)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 29685 Neighboring gene protein phosphatase 1, regulatory subunit 12A Neighboring gene predicted gene, 23105 Neighboring gene predicted gene, 36283 Neighboring gene predicted gene, 36440 Neighboring gene predicted gene, 36601 Neighboring gene synaptotagmin I

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables leucine zipper domain binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase C binding ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase 1 binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in calcium ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in detection of mechanical stimulus involved in sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
involved_in detection of temperature stimulus involved in sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within interleukin-2 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of B cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of calcium ion import ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of epithelial to mesenchymal transition NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of action potential ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of amyloid precursor protein biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cellular senescence IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of hindgut contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of hydrogen peroxide-mediated programmed cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of leukocyte tethering or rolling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuronal action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neutrophil extravasation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of relaxation of smooth muscle ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with actin filament ISO
Inferred from Sequence Orthology
more info
 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
PRKC apoptosis WT1 regulator protein
Names
prostate apoptosis response 4 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_054056.2NP_473397.1  PRKC apoptosis WT1 regulator protein

    See identical proteins and their annotated locations for NP_473397.1

    Status: VALIDATED

    Source sequence(s)
    AW123400, DQ363525, DV057979
    Consensus CDS
    CCDS36053.1
    UniProtKB/Swiss-Prot
    Q2HYJ1, Q925B0
    Related
    ENSMUSP00000092951.4, ENSMUST00000095313.5
    Conserved Domains (1) summary
    cl00459
    Location:255331
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    108168050..108250708
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155514.1XP_036011407.1  PRKC apoptosis WT1 regulator protein isoform X1

    Conserved Domains (1) summary
    COG1196
    Location:326387
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]