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PGLYRP3 peptidoglycan recognition protein 3 [ Homo sapiens (human) ]

Gene ID: 114771, updated on 8-Jul-2021

Summary

Official Symbol
PGLYRP3provided by HGNC
Official Full Name
peptidoglycan recognition protein 3provided by HGNC
Primary source
HGNC:HGNC:30014
See related
Ensembl:ENSG00000159527 MIM:608197
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PGRPIA; PGRP-Ialpha; PGLYRPIalpha
Summary
This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. These proteins are part of the innate immune system and recognize peptidoglycan, a ubiquitous component of bacterial cell walls. This antimicrobial protein binds to murein peptidoglycans of Gram-positive bacteria. [provided by RefSeq, Oct 2014]
Expression
Biased expression in skin (RPKM 19.2) and esophagus (RPKM 11.8) See more
Orthologs
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Genomic context

See PGLYRP3 in Genome Data Viewer
Location:
1q21.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (153297116..153312975, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (153269592..153285428, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein lateral stalk subunit P0 pseudogene 4 Neighboring gene loricrin cornified envelope precursor protein Neighboring gene peptidoglycan recognition protein 4 Neighboring gene RNA, U6 small nuclear 160, pseudogene Neighboring gene S100 calcium binding protein A9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC149197

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables N-acetylmuramoyl-L-alanine amidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidoglycan binding IDA
Inferred from Direct Assay
more info
PubMed 
enables peptidoglycan immune receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in membrane NAS
Non-traceable Author Statement
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
peptidoglycan recognition protein 3
Names
peptidoglycan recognition protein I alpha
peptidoglycan recognition protein intermediate alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052891.3NP_443123.1  peptidoglycan recognition protein 3 precursor

    See identical proteins and their annotated locations for NP_443123.1

    Status: REVIEWED

    Source sequence(s)
    AL161636, AL591704
    Consensus CDS
    CCDS1035.1
    UniProtKB/Swiss-Prot
    Q96LB9
    Related
    ENSP00000507327.1, ENST00000683862.1
    Conserved Domains (1) summary
    smart00701
    Location:179319
    PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    153297116..153312975 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509118.1XP_011507420.1  peptidoglycan recognition protein 3 isoform X1

    Conserved Domains (1) summary
    smart00701
    Location:215355
    PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme
  2. XM_011509120.2XP_011507422.1  peptidoglycan recognition protein 3 isoform X3

    Conserved Domains (1) summary
    smart00701
    Location:177317
    PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme

RNA

  1. XR_921736.1 RNA Sequence

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