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Mapre1 microtubule-associated protein, RP/EB family, member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 114764, updated on 5-Sep-2025
Official Symbol
Mapre1provided by RGD
Official Full Name
microtubule-associated protein, RP/EB family, member 1provided by RGD
Primary source
RGD:621781
See related
Ensembl:ENSRNOG00000011798 AllianceGenome:RGD:621781
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Eb1
Summary
Enables microtubule plus-end binding activity. Predicted to be involved in several processes, including microtubule cytoskeleton organization; protein localization to microtubule cytoskeleton; and regulation of microtubule polymerization. Predicted to act upstream of or within non-motile cilium assembly and protein localization to centrosome. Predicted to be located in several cellular components, including cell projection membrane; focal adhesion; and microtubule cytoskeleton. Predicted to be active in microtubule cytoskeleton. Orthologous to human MAPRE1 (microtubule associated protein RP/EB family member 1). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Thymus (RPKM 344.9), Spleen (RPKM 300.0) and 9 other tissues See more
Orthologs
human mouse all
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See Mapre1 in Genome Data Viewer
Location:
3q41
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (162679020..162707167)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (142218846..142246990)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (149221346..149249469)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene COMM domain containing 7 Neighboring gene DNA methyltransferase 3 beta Neighboring gene DNA methyltransferase 3B, pseudogene 1 Neighboring gene uncharacterized LOC120101759 Neighboring gene ribosomal protein S27a, pseudogene 8 Neighboring gene uncharacterized LOC134486189 Neighboring gene EF-hand calcium binding domain 8 Neighboring gene Sad1 and UNC84 domain containing 5

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. NC1-peptide regulates spermatogenesis through changes in cytoskeletal organization mediated by EB1. Liu S, et al. FASEB J, 2020 Feb. PMID 31909540
  2. EB 1 immunofluorescence reveals an increase in growing astral microtubule length and number during anaphase in NRK-52E cells. Morrison EE, et al. Eur J Cell Biol, 2001 Dec. PMID 11831388
  3. EB1 regulates tubulin and actin cytoskeletal networks at the sertoli cell blood-testis barrier in male rats: an in vitro study. Tang EI, et al. Endocrinology, 2015 Feb. PMID 25456071, Free PMC Article
  4. End-binding proteins EB3 and EB1 link microtubules to ankyrin G in the axon initial segment. Leterrier C, et al. Proc Natl Acad Sci U S A, 2011 May 24. PMID 21551097, Free PMC Article
  5. Adenomatous polyposis coli on microtubule plus ends in cell extensions can promote microtubule net growth with or without EB1. Kita K, et al. Mol Biol Cell, 2006 May. PMID 16525027, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NC1-peptide regulates spermatogenesis through changes in cytoskeletal organization mediated by EB1.
    Title: NC1-peptide regulates spermatogenesis through changes in cytoskeletal organization mediated by EB1.
  2. provides a functional link between tubulin- and actin-based cytoskeletons to confer spermatocyte transport at the blood-testis barrier
    Title: EB1 regulates tubulin and actin cytoskeletal networks at the sertoli cell blood-testis barrier in male rats: an in vitro study.
  3. the Amer2-EB1-APC complex regulates cell migration by altering microtubule stability.
    Title: Amer2 protein interacts with EB1 protein and adenomatous polyposis coli (APC) and controls microtubule stability and cell migration.
  4. EB3 and EB1 coordinate a molecular and functional interplay between ankyrin G (ankG)and the axon initial segment microtubules that supports the central role of ankG in the maintenance of neuronal polarity
    Title: End-binding proteins EB3 and EB1 link microtubules to ankyrin G in the axon initial segment.
  5. In this study we used EB1 immunostaining in mitotic NRK-52E cells to quantitatively analyse the length and number of growing astral microtubules during metaphase and anaphase
    Title: EB 1 immunofluorescence reveals an increase in growing astral microtubule length and number during anaphase in NRK-52E cells.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule plus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule plus-end binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule plus-end binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule plus-end binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in attachment of mitotic spindle microtubules to kinetochore ISO
Inferred from Sequence Orthology
more info
  
involved_in attachment of mitotic spindle microtubules to kinetochore ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of mitotic spindle orientation ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of mitotic spindle orientation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in microtubule bundle formation ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within non-motile cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to astral microtubule ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to astral microtubule ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within protein localization to centrosome ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein localization to microtubule ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to microtubule ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to microtubule ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization to mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of microtubule polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection membrane ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
located_in cortical microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule ISO
Inferred from Sequence Orthology
more info
  
is_active_in microtubule ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in microtubule ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule plus-end IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule plus-end ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle astral microtubule end ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle microtubule ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitotic spindle pole ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitotic spindle pole ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in spindle IEA
Inferred from Electronic Annotation
more info
  
located_in spindle ISO
Inferred from Sequence Orthology
more info
  
is_active_in spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
microtubule-associated protein RP/EB family member 1
Names
APC-binding protein EB1
adenomatosis polyposis coli binding protein Eb1
end-binding protein 1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429678.1 → NP_001416607.1  microtubule-associated protein RP/EB family member 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q66HR2
    UniProtKB/TrEMBL
    A0A8L2Q865, A6KHW5

  2. NM_001429679.1 → NP_001416608.1  microtubule-associated protein RP/EB family member 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q66HR2
    UniProtKB/TrEMBL
    A0A8L2Q865, A6KHW5

  3. NM_001429680.1 → NP_001416609.1  microtubule-associated protein RP/EB family member 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q66HR2
    UniProtKB/TrEMBL
    A0A8L2Q865, A6KHW5

  4. NM_138509.4 → NP_612518.2  microtubule-associated protein RP/EB family member 1

    See identical proteins and their annotated locations for NP_612518.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q66HR2
    UniProtKB/TrEMBL
    A0A8L2Q865, A6KHW5
    Related
    ENSRNOP00000016220.6, ENSRNOT00000016220.8
    Conserved Domains (1) summary
    COG5217
    Location:16 → 257
    BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    162679020..162707167
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006235295.5 → XP_006235357.1  microtubule-associated protein RP/EB family member 1 isoform X1

    Conserved Domains (1) summary
    COG5217
    Location:16 → 257
    BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]

  2. XM_006235294.5 → XP_006235356.1  microtubule-associated protein RP/EB family member 1 isoform X1

    Conserved Domains (1) summary
    COG5217
    Location:16 → 257
    BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]

  3. XM_039104099.2 → XP_038960027.1  microtubule-associated protein RP/EB family member 1 isoform X1

    Conserved Domains (1) summary
    COG5217
    Location:16 → 257
    BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66HR2.3 GenPept UniProtKB/Swiss-Prot:Q66HR2

Gene LinkOut

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