U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Supt16 SPT16, facilitates chromatin remodeling subunit [ Mus musculus (house mouse) ]

Gene ID: 114741, updated on 18-Sep-2024

Summary

Official Symbol
Supt16provided by MGI
Official Full Name
SPT16, facilitates chromatin remodeling subunitprovided by MGI
Primary source
MGI:MGI:1890948
See related
Ensembl:ENSMUSG00000035726 AllianceGenome:MGI:1890948
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cdc68; Spt16; Fact140; Supt16h
Summary
Predicted to enable nucleosome binding activity. Predicted to be involved in DNA replication-independent chromatin organization; positive regulation of transcription elongation from RNA polymerase II promoter; and transcription elongation from RNA polymerase II promoter. Predicted to act upstream of or within DNA repair and DNA replication. Predicted to be located in nucleoplasm. Predicted to be part of FACT complex. Is expressed in several structures, including alimentary system; brain; hindlimb phalanx; integumental system; and sensory organ. Orthologous to human SUPT16H (SPT16 homolog, facilitates chromatin remodeling subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 42.5), liver E14 (RPKM 20.1) and 23 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Supt16 in Genome Data Viewer
Location:
14 C2; 14 26.83 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (52397876..52434696, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (52160419..52197239, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein C Neighboring gene retinitis pigmentosa GTPase regulator interacting protein 1 Neighboring gene MRT4, mRNA turnover 4, homolog pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7310 Neighboring gene STARR-seq mESC enhancer starr_36700 Neighboring gene chromodomain helicase DNA binding protein 8 Neighboring gene predicted gene, 26590 Neighboring gene small nucleolar RNA, C/D box 8

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in nucleosome assembly NAS
Non-traceable Author Statement
more info
PubMed 
involved_in nucleosome disassembly ISO
Inferred from Sequence Orthology
more info
 
involved_in transcription elongation by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of FACT complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of FACT complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
FACT complex subunit SPT16
Names
FACT 140 kDa subunit
FACTp140
chromatin-specific transcription elongation factor 140 kDa subunit
facilitates chromatin transcription complex subunit SPT16
suppressor of Ty 16 homolog

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033618.3NP_291096.2  FACT complex subunit SPT16

    See identical proteins and their annotated locations for NP_291096.2

    Status: VALIDATED

    Source sequence(s)
    AC159323, AF323667, AI930189, AK148506, CB202003
    Consensus CDS
    CCDS27051.1
    UniProtKB/Swiss-Prot
    Q3TZ48, Q3UFH0, Q920B9, Q921H4
    UniProtKB/TrEMBL
    G3X956
    Related
    ENSMUSP00000042283.8, ENSMUST00000046709.9
    Conserved Domains (1) summary
    cl25953
    Location:51001
    SPT16; FACT complex subunit (SPT16/CDC68)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    52397876..52434696 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)