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Spred2 sprouty-related EVH1 domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 114716, updated on 21-May-2024

Summary

Official Symbol
Spred2provided by MGI
Official Full Name
sprouty-related EVH1 domain containing 2provided by MGI
Primary source
MGI:MGI:2150019
See related
Ensembl:ENSMUSG00000045671 AllianceGenome:MGI:2150019
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables protein kinase binding activity; protein serine/threonine kinase inhibitor activity; and stem cell factor receptor binding activity. Involved in negative regulation of cell differentiation; regulation of protein modification process; and regulation of signal transduction. Acts upstream of or within negative regulation of MAPK cascade. Located in cytoplasmic vesicle and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; heart; and sensory organ. Used to study achondroplasia. Orthologous to human SPRED2 (sprouty related EVH1 domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 1.8), adrenal adult (RPKM 1.8) and 28 other tissues See more
Orthologs
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Genomic context

See Spred2 in Genome Data Viewer
Location:
11 A3.1; 11 12.79 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (19874442..19974026)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (19924442..20024026)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39602 Neighboring gene 40S ribosomal protein S2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3934 Neighboring gene STARR-seq mESC enhancer starr_28754 Neighboring gene STARR-seq mESC enhancer starr_28757 Neighboring gene STARR-seq mESC enhancer starr_28758 Neighboring gene STARR-seq mESC enhancer starr_28760 Neighboring gene STARR-positive B cell enhancer ABC_E10665 Neighboring gene STARR-seq mESC enhancer starr_28762 Neighboring gene STARR-seq mESC enhancer starr_28763 Neighboring gene STARR-seq mESC enhancer starr_28769 Neighboring gene predicted gene, 39603 Neighboring gene predicted gene, 32080 Neighboring gene actin related protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E1412 Neighboring gene STARR-positive B cell enhancer ABC_E9359

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables stem cell factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
sprouty-related, EVH1 domain-containing protein 2
Names
sprouty protein with EVH-1 domain 2, related sequence

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033523.4NP_277058.1  sprouty-related, EVH1 domain-containing protein 2

    See identical proteins and their annotated locations for NP_277058.1

    Status: PROVISIONAL

    Source sequence(s)
    AL645609, AL672084
    Consensus CDS
    CCDS24454.1
    UniProtKB/Swiss-Prot
    Q924S7
    UniProtKB/TrEMBL
    Q5SRF8
    Related
    ENSMUSP00000090987.6, ENSMUST00000093298.12
    Conserved Domains (2) summary
    cd10574
    Location:12124
    EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
    pfam05210
    Location:299397
    Sprouty; Sprouty protein (Spry)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    19874442..19974026
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514456.5XP_006514519.1  sprouty-related, EVH1 domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    Q5SRF8
    Conserved Domains (2) summary
    cd10574
    Location:29141
    EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
    pfam05210
    Location:316414
    Sprouty; Sprouty protein (Spry)
  2. XM_006514458.5XP_006514521.1  sprouty-related, EVH1 domain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    Q5SRF8
    Related
    ENSMUSP00000159978.1, ENSMUST00000249881.1
    Conserved Domains (2) summary
    cd10574
    Location:9121
    EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
    pfam05210
    Location:296394
    Sprouty; Sprouty protein (Spry)
  3. XM_036156236.1XP_036012129.1  sprouty-related, EVH1 domain-containing protein 2 isoform X4

    UniProtKB/TrEMBL
    Q5SRF8
    Conserved Domains (2) summary
    cd10574
    Location:1104
    EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
    pfam05210
    Location:278383
    Sprouty; Sprouty protein (Spry)
  4. XM_006514457.5XP_006514520.1  sprouty-related, EVH1 domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    Q5SRF8
    Conserved Domains (2) summary
    cd10574
    Location:12124
    EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
    pfam05210
    Location:299397
    Sprouty; Sprouty protein (Spry)