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Spred1 sprouty protein with EVH-1 domain 1, related sequence [ Mus musculus (house mouse) ]

Gene ID: 114715, updated on 28-Oct-2022

Summary

Official Symbol
Spred1provided by MGI
Official Full Name
sprouty protein with EVH-1 domain 1, related sequenceprovided by MGI
Primary source
MGI:MGI:2150016
See related
Ensembl:ENSMUSG00000027351 AllianceGenome:MGI:2150016
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5730461F13Rik
Summary
This gene encodes a membrane-associated protein that is phosphorylated by tyrosine kinases in response to growth factors. The encoded protein acts as a negative regulator of the mitogen-activated protein (MAP) kinase signaling pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
Expression
Ubiquitous expression in adrenal adult (RPKM 12.0), cortex adult (RPKM 10.9) and 27 other tissues See more
Orthologs
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Genomic context

See Spred1 in Genome Data Viewer
Location:
2; 2 E5
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (116951552..117012760)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (117121071..117182279)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39912 Neighboring gene predicted gene, 54145 Neighboring gene microRNA 674 Neighboring gene voltage-dependent anion channel 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables stem cell factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell migration involved in sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of epithelial to mesenchymal transition IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of lens fiber cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of protein deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in vasculogenesis involved in coronary vascular morphogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
sprouty-related, EVH1 domain-containing protein 1
Names
sprouty-related protein 1 with EVH-1 domain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277256.2NP_001264185.1  sprouty-related, EVH1 domain-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL807741, AL928959
    Consensus CDS
    CCDS71115.1
    UniProtKB/Swiss-Prot
    Q924S8
    Related
    ENSMUSP00000106526.2, ENSMUST00000110901.2
    Conserved Domains (1) summary
    cd10574
    Location:13125
    EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
  2. NM_033524.4NP_277059.1  sprouty-related, EVH1 domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_277059.1

    Status: VALIDATED

    Source sequence(s)
    AL807741, AL928959
    Consensus CDS
    CCDS16570.1
    UniProtKB/Swiss-Prot
    Q6PET8, Q924S8
    Related
    ENSMUSP00000028829.7, ENSMUST00000028829.13
    Conserved Domains (2) summary
    cd10574
    Location:13125
    EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
    pfam05210
    Location:333428
    Sprouty; Sprouty protein (Spry)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    116951552..117012760
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)