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Rad51c RAD51 paralog C [ Mus musculus (house mouse) ]

Gene ID: 114714, updated on 5-Jan-2023

Summary

Official Symbol
Rad51cprovided by MGI
Official Full Name
RAD51 paralog Cprovided by MGI
Primary source
MGI:MGI:2150020
See related
Ensembl:ENSMUSG00000007646 AllianceGenome:MGI:2150020
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
R51H3; Rad51l2
Summary
Enables crossover junction endodeoxyribonuclease activity. Involved in telomere maintenance via recombination. Acts upstream of or within meiotic nuclear division and spermatogenesis. Located in nucleus. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group O and hereditary breast ovarian cancer syndrome. Orthologous to human RAD51C (RAD51 paralog C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 3.5), CNS E11.5 (RPKM 2.8) and 16 other tissues See more
Orthologs
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Genomic context

See Rad51c in Genome Data Viewer
Location:
11 C; 11 52.08 cM
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (87267471..87295780, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (87376645..87404954, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing 37 Neighboring gene protein phosphatase 1E (PP2C domain containing) Neighboring gene predicted gene, 33937 Neighboring gene predicted gene, 22883 Neighboring gene VISTA enhancer mm264 Neighboring gene testis expressed gene 14 Neighboring gene predicted gene, 22068 Neighboring gene U1a1 small nuclear RNA

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent DNA damage sensor activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to crossover junction DNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables crossover junction DNA endonuclease activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
contributes_to crossover junction DNA endonuclease activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to four-way junction DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to four-way junction DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of Holliday junction resolvase complex IC
Inferred by Curator
more info
PubMed 
part_of Holliday junction resolvase complex ISO
Inferred from Sequence Orthology
more info
 
part_of Rad51B-Rad51C-Rad51D-XRCC2 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of Rad51B-Rad51C-Rad51D-XRCC2 complex ISO
Inferred from Sequence Orthology
more info
 
part_of Rad51C-XRCC3 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of Rad51C-XRCC3 complex ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in replication fork IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in replication fork ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
DNA repair protein RAD51 homolog 3
Names
RAD51 homolog C
RAD51-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291440.2NP_001278369.1  DNA repair protein RAD51 homolog 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL596130, AL669902
    Consensus CDS
    CCDS79013.1
    UniProtKB/Swiss-Prot
    Q924H5
    Related
    ENSMUSP00000007790.5, ENSMUST00000007790.11
    Conserved Domains (2) summary
    cd01123
    Location:109356
    Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
    pfam08423
    Location:95358
    Rad51; Rad51
  2. NM_053269.4NP_444499.1  DNA repair protein RAD51 homolog 3 isoform 2

    See identical proteins and their annotated locations for NP_444499.1

    Status: VALIDATED

    Source sequence(s)
    AL596130, AL669902, BC090648, BY720217
    Consensus CDS
    CCDS25212.1
    UniProtKB/Swiss-Prot
    Q8C653, Q924H5
    Related
    ENSMUSP00000064079.7, ENSMUST00000067692.13
    Conserved Domains (2) summary
    PRK04301
    Location:12340
    radA; DNA repair and recombination protein RadA; Validated
    cd01123
    Location:91338
    Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...

RNA

  1. NR_156495.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK136204, AL596130, AL669902

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    87267471..87295780 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156234.1XP_036012127.1  DNA repair protein RAD51 homolog 3 isoform X1

  2. XM_036156235.1XP_036012128.1  DNA repair protein RAD51 homolog 3 isoform X2

    Conserved Domains (2) summary
    PRK04301
    Location:12166
    radA; DNA repair and recombination protein RadA; Validated
    cl38936
    Location:109226
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases