Actl7b actin-like 7b [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Actl7bprovided by MGI
Official Full Name: actin-like 7bprovided by MGI
Primary source: MGI:MGI:1343053
See related: Ensembl:ENSMUSG00000070980 AllianceGenome:MGI:1343053
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tact1; Gm26657
Summary: Located in cytoplasm. Is expressed in male reproductive gland or organ and small intestine. Orthologous to human ACTL7B (actin like 7B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 4 B3; 4 31.66 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (56740005..56741425, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (56740005..56741425, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results suggest that T-ACTINs play important roles in sperm function and in the specific morphogenesis of spermatozoa during spermiogenesis
Title: Novel actin-like proteins T-ACTIN 1 and T-ACTIN 2 are differentially expressed in the cytoplasm and nucleus of mouse haploid germ cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

General gene information

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Markers

UniSTS:492614 (e-PCR)
- UniSTS:492614

Actl7b (e-PCR), detects polymorphism
- UniSTS:141019

Homology

Homologs of the Actl7b gene: The Actl7b gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, and rat.
Orthologs from Annotation Pipeline: 201 organisms have orthologs with human gene Actl7b
Orthologs

Gene Ontology Provided by MGI

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: actin-like protein 7B

Names: T-actin-1; actin-like-7-beta; t-actin 1; testis-specific actin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025271.2 → NP_079547.2 actin-like protein 7B

See identical proteins and their annotated locations for NP_079547.2

Status: VALIDATED

Source sequence(s)

BC116815, BX634818, BY091849

Consensus CDS

CCDS18196.1

UniProtKB/Swiss-Prot

Q9JMI6, Q9QY83

UniProtKB/TrEMBL

A0A8C6GJC9

Related

ENSMUSP00000092693.4, ENSMUST00000095080.5

Conserved Domains (2) summary

smart00268
Location:52 → 418

ACTIN; Actin

cl17037
Location:53 → 418

NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily