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CHUK component of inhibitor of nuclear factor kappa B kinase complex [ Homo sapiens (human) ]

Gene ID: 1147, updated on 24-Nov-2020

Summary

Official Symbol
CHUKprovided by HGNC
Official Full Name
component of inhibitor of nuclear factor kappa B kinase complexprovided by HGNC
Primary source
HGNC:HGNC:1974
See related
Ensembl:ENSG00000213341 MIM:600664
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IKK1; IKKA; IKBKA; TCF16; NFKBIKA; IKK-alpha
Summary
This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 4.9), bone marrow (RPKM 4.7) and 25 other tissues See more
Orthologs

Genomic context

See CHUK in Genome Data Viewer
Location:
10q24.31
Exon count:
23
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (100188300..100229610, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (101948123..101989367, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene signal peptidase complex subunit 2 pseudogene 2 Neighboring gene ER lipid raft associated 1 Neighboring gene CWF19 like cell cycle control factor 1 Neighboring gene small nucleolar RNA, H/ACA box 12 Neighboring gene prohibitin pseudogene 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Cocoon syndrome
MedGen: C3150891 OMIM: 613630 GeneReviews: Not available
Compare labs
Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120/CD4 interaction-induced NF-kappaB activation stimulates the hyperphosphorylation of IkappaB-alpha by IkappaB kinases (IKKs) PubMed
Nef nef HIV-1 Nef induces phosphorylation of CHUK (IKKalpha) PubMed
nef HIV-1 Nef-induced strong activation of MAP kinases (p38/MAPK14, JNK/MAPK8, and ERK1/2) and NF-kappaB pathway (IKK alpha/beta) in M2-macrophages is mediated by TAK1 PubMed
nef HIV-1 Nef induces phosphorylation of IKKalpha in M2-type macrophages PubMed
nef The interaction of HIV-1 Nef with TRAF2, TRAF5, and TRAF6 proteins activates NF-kappaB, leading to the degradation of IkappaB-alpha and the increased phosphorylation of IKK-alpha and IKK-beta in monocyte-derived macrophages PubMed
nef HIV-1 Nef myristoylation is required for the rapid and transient phosphorylation of the alpha- and beta- subunits of the Ikappa-B kinase complex and activation of JNK, ERK1/2 and p38 MAPK family members PubMed
Tat tat HIV-1 Tat induces phosphorylation of CHUK (IKKalpha) in CRT-MG human astroglioma cells PubMed
tat HIV-1 Tat induces phosphorylation of IKK-alpha/IKK-beta in human astroglioma cells PubMed
tat HIV-1 Tat induces phosphorylation of IKK in HeLa-CD4-long terminal repeat (LTR)-beta-gal (MAGI) cells PubMed
tat Tat stimulates NF-kappaB-inducing kinase IKKalpha translocation from the cytoplasm to the nucleus in monocytes, which leads to IKKalpha and CBP/p300 recruitment to the IL-10 promoter and histone H3 phosphorylation (Ser 10) and acetylation (Lys 14) PubMed
tat Tat activates at least three signaling pathways concurrently, including NF-kappaB, PKC, ERK1/2 and p38 MAP kinases and IKKalpha pathways, to promote production of IL-10 PubMed
Vpr vpr HIV-1 Vpr requires CHUK (IKKa) or IKBKB (IKKb) to induce G2/M arrest in HeLa cells as shown through siRNA knockdown of CHUK (IKKa) or IKBKB (IKKb) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to IkappaB kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
IkappaB kinase activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
scaffold protein binding IDA
Inferred from Direct Assay
more info
PubMed 
transferrin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
 
I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
I-kappaB kinase/NF-kappaB signaling TAS
Traceable Author Statement
more info
PubMed 
I-kappaB phosphorylation TAS
Traceable Author Statement
more info
PubMed 
MyD88-independent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
NIK/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
NIK/NF-kappaB signaling TAS
Traceable Author Statement
more info
 
Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
T cell receptor signaling pathway TAS
Traceable Author Statement
more info
 
TRIF-dependent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
anatomical structure morphogenesis TAS
Traceable Author Statement
more info
PubMed 
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS
Traceable Author Statement
more info
 
cellular response to cadmium ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to reactive oxygen species IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to tumor necrosis factor IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
immune response TAS
Traceable Author Statement
more info
PubMed 
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
innate immune response TAS
Traceable Author Statement
more info
PubMed 
interleukin-1-mediated signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling TAS
Traceable Author Statement
more info
 
positive regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
positive regulation of interferon-alpha production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of tumor necrosis factor-mediated signaling pathway TAS
Traceable Author Statement
more info
 
response to acetate IEA
Inferred from Electronic Annotation
more info
 
response to amino acid IEA
Inferred from Electronic Annotation
more info
 
response to cholecystokinin IEA
Inferred from Electronic Annotation
more info
 
response to drug IEA
Inferred from Electronic Annotation
more info
 
response to hydroperoxide IEA
Inferred from Electronic Annotation
more info
 
response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
response to toxic substance IEA
Inferred from Electronic Annotation
more info
 
response to virus TAS
Traceable Author Statement
more info
PubMed 
skeletal muscle contraction IEA
Inferred from Electronic Annotation
more info
 
stimulatory C-type lectin receptor signaling pathway TAS
Traceable Author Statement
more info
 
stress-activated MAPK cascade TAS
Traceable Author Statement
more info
 
striated muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
tumor necrosis factor-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
CD40 receptor complex ISS
Inferred from Sequence or Structural Similarity
more info
 
IkappaB kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
IkappaB kinase complex TAS
Traceable Author Statement
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic side of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
inhibitor of nuclear factor kappa-B kinase subunit alpha
Names
I-kappa-B kinase 1
I-kappa-B kinase-alpha
IKK-a kinase
IkB kinase alpha subunit
Nuclear factor NFkappaB inhibitor kinase alpha
TCF-16
conserved helix-loop-helix ubiquitous kinase
transcription factor 16
NP_001269.3
NP_001307857.1
XP_016871100.1
XP_016871101.1
XP_016871102.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028023.1 RefSeqGene

    Range
    4992..46288
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001278.5NP_001269.3  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1

    See identical proteins and their annotated locations for NP_001269.3

    Status: REVIEWED

    Source sequence(s)
    AF080157, AI829429, BC034796, BM800404, DA405845
    Consensus CDS
    CCDS7488.1
    UniProtKB/Swiss-Prot
    O15111
    Related
    ENSP00000359424.6, ENST00000370397.8
    Conserved Domains (2) summary
    cd14039
    Location:21309
    STKc_IKK_alpha; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) alpha
    pfam12179
    Location:709743
    IKKbetaNEMObind; I-kappa-kinase-beta NEMO binding domain
  2. NM_001320928.2NP_001307857.1  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 2

    Status: REVIEWED

    Source sequence(s)
    AI829429, AL138921, DA405845
    Conserved Domains (2) summary
    smart00220
    Location:15298
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14039
    Location:21309
    STKc_IKK_alpha; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) alpha

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    100188300..100229610 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017015611.1XP_016871100.1  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1

  2. XM_017015613.1XP_016871102.1  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X3

  3. XM_017015612.1XP_016871101.1  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X2

RNA

  1. XR_001747011.1 RNA Sequence

  2. XR_001747010.1 RNA Sequence

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