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Actg2 actin, gamma 2, smooth muscle, enteric [ Mus musculus (house mouse) ]

Gene ID: 11468, updated on 5-Mar-2024

Summary

Official Symbol
Actg2provided by MGI
Official Full Name
actin, gamma 2, smooth muscle, entericprovided by MGI
Primary source
MGI:MGI:104589
See related
Ensembl:ENSMUSG00000059430 AllianceGenome:MGI:104589
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Act4; SMGA; ACTA3; Act-4
Summary
Predicted to enable ATP binding activity. Located in cell periphery. Is expressed in alimentary system and genitourinary system. Human ortholog(s) of this gene implicated in megacystis-microcolon-intestinal hypoperistalsis syndrome. Orthologous to human ACTG2 (actin gamma 2, smooth muscle). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 2840.7), colon adult (RPKM 638.4) and 4 other tissues See more
Orthologs
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Genomic context

See Actg2 in Genome Data Viewer
Location:
6 C3; 6 35.94 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (83489891..83513233, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (83512909..83536251, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene tet methylcytosine dioxygenase 3 Neighboring gene RIKEN cDNA B230319C09 gene Neighboring gene STARR-seq mESC enhancer starr_16466 Neighboring gene deoxyguanosine kinase Neighboring gene STARR-positive B cell enhancer ABC_E1066 Neighboring gene STAM binding protein Neighboring gene DENN/MADD domain containing 4C pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3660 Neighboring gene predicted gene, 21284

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
actin, gamma-enteric smooth muscle
Names
alpha-actin-3
gamma-2-actin
smooth muscle gamma-actin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009610.2NP_033740.2  actin, gamma-enteric smooth muscle

    See identical proteins and their annotated locations for NP_033740.2

    Status: VALIDATED

    Source sequence(s)
    AI154766, AK168649, BY778654
    Consensus CDS
    CCDS51822.1
    UniProtKB/Swiss-Prot
    P63268
    UniProtKB/TrEMBL
    Q3U122, Q3UJ36
    Related
    ENSMUSP00000074658.6, ENSMUST00000075161.12
    Conserved Domains (1) summary
    PTZ00281
    Location:1376
    PTZ00281; actin; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    83489891..83513233 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)