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Prss29 protease, serine 29 [ Mus musculus (house mouse) ]

Gene ID: 114662, updated on 26-Sep-2022

Summary

Official Symbol
Prss29provided by MGI
Official Full Name
protease, serine 29provided by MGI
Primary source
MGI:MGI:2149952
See related
Ensembl:ENSMUSG00000034039 AllianceGenome:MGI:2149952
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Isp2; mISP-2
Summary
Enables serine-type peptidase activity. Acts upstream of or within blastocyst hatching; embryo implantation; and proteolysis. Located in extracellular space. Is expressed in embryo; liver; lung; spleen; and uterus. Orthologous to human PRSS29P (serine protease 29, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

See Prss29 in Genome Data Viewer
Location:
17 A3.3; 17 12.53 cM
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25537628..25541658)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25318654..25322684)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 25921 Neighboring gene protease, serine 28 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene tryptase alpha/beta 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (3)  1 citation

General gene information

Markers

Homology

Clone Names

  • MGC123865

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables serine-type peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables serine-type peptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within blastocyst hatching IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within blastocyst hatching IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryo implantation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within proteolysis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine protease 29
Names
ISP-2
implantation serine protease 2
implantation serine proteinase 2
strypsin-2
strypsin-related protein
tryptase-like proteinase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053260.3NP_444490.2  serine protease 29 precursor

    Status: PROVISIONAL

    Source sequence(s)
    AK144368, BX632512
    Consensus CDS
    CCDS28516.1
    UniProtKB/Swiss-Prot
    Q99MS4
    UniProtKB/TrEMBL
    E9QLD5
    Related
    ENSMUSP00000024993.8, ENSMUST00000024993.9
    Conserved Domains (2) summary
    smart00020
    Location:31271
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:31274
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    25537628..25541658
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)