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LRRC37B leucine rich repeat containing 37B [ Homo sapiens (human) ]

Gene ID: 114659, updated on 1-Jun-2020

Summary

Official Symbol
LRRC37Bprovided by HGNC
Official Full Name
leucine rich repeat containing 37Bprovided by HGNC
Primary source
HGNC:HGNC:29070
See related
Ensembl:ENSG00000185158 MIM:616558
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LRRC37
Expression
Broad expression in testis (RPKM 10.5), bone marrow (RPKM 7.6) and 23 other tissues See more
Orthologs

Genomic context

See LRRC37B in Genome Data Viewer
Location:
17q11.2
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (32007383..32053487)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (30348155..30380519)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene SUZ12 polycomb repressive complex 2 subunit Neighboring gene RNA, 5S ribosomal pseudogene 437 Neighboring gene SUZ12 PRS4 recombination region Neighboring gene NF1-REPc UWA160-1 recombination region Neighboring gene leucine-rich repeat-containing protein 37A3-like Neighboring gene SH3 domain containing GRB2 like 1, endophilin A2 pseudogene 1 Neighboring gene NF1-REPc PRS1 recombination region Neighboring gene NF1-REPc PRS2 recombination region Neighboring gene uncharacterized LOC102724625

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
leucine-rich repeat-containing protein 37B
Names
C66 SLIT-like testicular protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321350.2NP_001308279.1  leucine-rich repeat-containing protein 37B isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an upstream promoter, differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (2) lacks a predicted signal peptide compared to isoform 1.
    Source sequence(s)
    AC090616, AK299772, AK302740, DB475546
    Consensus CDS
    CCDS82102.1
    UniProtKB/TrEMBL
    B4DSJ3, B4DZ43, F5H5K1
    Related
    ENSP00000443345.2, ENST00000543378.6
    Conserved Domains (5) summary
    sd00031
    Location:499522
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:523561
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:500557
    LRR_8; Leucine rich repeat
    pfam14914
    Location:713855
    LRRC37AB_C; LRRC37A/B like protein 1 C-terminal domain
    pfam15779
    Location:213281
    LRRC37; Leucine-rich repeat-containing protein 37 family
  2. NM_052888.3NP_443120.2  leucine-rich repeat-containing protein 37B isoform 1 precursor

    See identical proteins and their annotated locations for NP_443120.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1), which contains a predicted signal peptide.
    Source sequence(s)
    AC090616, AK302740
    Consensus CDS
    CCDS32609.1
    UniProtKB/Swiss-Prot
    Q96QE4
    Related
    ENSP00000378202.4, ENST00000394713.7
    Conserved Domains (5) summary
    sd00031
    Location:581604
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:605643
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:582639
    LRR_8; Leucine rich repeat
    pfam14914
    Location:795937
    LRRC37AB_C; LRRC37A/B like protein 1 C-terminal domain
    pfam15779
    Location:295363
    LRRC37; Leucine-rich repeat-containing protein 37 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    32007383..32053487
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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