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Slc13a3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 [ Mus musculus (house mouse) ]

Gene ID: 114644, updated on 2-Nov-2024

Summary

Official Symbol
Slc13a3provided by MGI
Official Full Name
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3provided by MGI
Primary source
MGI:MGI:2149635
See related
Ensembl:ENSMUSG00000018459 AllianceGenome:MGI:2149635
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NaC3; NaDC3; SDCT2; NaDC-3
Summary
Enables high-affinity sodium:dicarboxylate symporter activity and succinate transmembrane transporter activity. Involved in succinate transmembrane transport. Acts upstream of or within dicarboxylic acid transport. Located in membrane. Is expressed in several structures, including central nervous system; esophagus; male reproductive gland or organ; metanephros; and retina. Orthologous to human SLC13A3 (solute carrier family 13 member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in kidney adult (RPKM 238.1), liver E18 (RPKM 17.7) and 1 other tissue See more
Orthologs
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Genomic context

See Slc13a3 in Genome Data Viewer
Location:
2 H3; 2 85.54 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (165247215..165315117, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (165405295..165473197, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_06348 Neighboring gene zinc finger protein 334 Neighboring gene osteoclast stimulatory transmembrane protein Neighboring gene origin of replication near adenosine deaminase Neighboring gene predicted gene 14437 Neighboring gene transformation related protein 53 regulating kinase A Neighboring gene solute carrier family 2 (facilitated glucose transporter), member 10

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-aspartate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables alpha-ketoglutarate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables alpha-ketoglutarate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables amide transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables citrate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables citrate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables dicarboxylic acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables glutathione transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables glutathione transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables high-affinity sodium:dicarboxylate symporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables modified amino acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables organic acid:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables sodium:dicarboxylate symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sodium:dicarboxylate symporter activity ISO
Inferred from Sequence Orthology
more info
 
enables succinate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables succinate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables succinate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in alpha-ketoglutarate transport IEA
Inferred from Electronic Annotation
more info
 
involved_in aspartate transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in carboxylic acid transport ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in citrate transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in citrate transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within dicarboxylic acid transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in dicarboxylic acid transport ISO
Inferred from Sequence Orthology
more info
 
involved_in glutathione transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in glutathione transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in succinate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in succinate transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in succinate transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in succinate transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
Na(+)/dicarboxylate cotransporter 3
Names
Na(+)-coupled carboxylate transporter 3
mNaDC3
sodium-dependent high-affinity dicarboxylate transporter 2
solute carrier family 13 member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_054055.2NP_473396.1  Na(+)/dicarboxylate cotransporter 3

    See identical proteins and their annotated locations for NP_473396.1

    Status: PROVISIONAL

    Source sequence(s)
    AL591064
    Consensus CDS
    CCDS17081.1
    UniProtKB/Swiss-Prot
    Q91Y63
    UniProtKB/TrEMBL
    A2A4U9, Q3UUJ6
    Related
    ENSMUSP00000029208.9, ENSMUST00000029208.15
    Conserved Domains (2) summary
    cd01115
    Location:42556
    SLC13_permease; Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is ...
    TIGR00785
    Location:31565
    dass; anion transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    165247215..165315117 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)