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Oas1c 2'-5' oligoadenylate synthetase 1C [ Mus musculus (house mouse) ]

Gene ID: 114643, updated on 8-Feb-2024

Summary

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Official Symbol
Oas1cprovided by MGI
Official Full Name
2'-5' oligoadenylate synthetase 1Cprovided by MGI
Primary source
MGI:MGI:2149633
See related
Ensembl:ENSMUSG00000001166 AllianceGenome:MGI:2149633
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Oasl2; Oasl5
Summary
Enables double-stranded RNA binding activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; regulation of cytokine production; and toll-like receptor signaling pathway. Predicted to be located in mitochondrion and ribosome. Predicted to be active in cytosol; membrane; and nucleoplasm. Predicted to colocalize with cytoplasm. Orthologous to human OAS1 (2'-5'-oligoadenylate synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 4.5), placenta adult (RPKM 3.1) and 20 other tissues See more
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Genomic context

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See Oas1c in Genome Data Viewer
Location:
5 F; 5 60.64 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (120938259..120950605, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (120800194..120812540, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene 2'-5' oligoadenylate synthetase 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:121225553-121225736 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:121225792-121225979 Neighboring gene 2'-5' oligoadenylate synthetase 1E Neighboring gene STARR-positive B cell enhancer ABC_E1306 Neighboring gene STARR-seq mESC enhancer starr_14251 Neighboring gene 2'-5' oligoadenylate synthetase 1B Neighboring gene STARR-seq mESC enhancer starr_14253 Neighboring gene 2'-5' oligoadenylate synthetase 1F

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning of a novel 2',5'-oligoadenylate synthetase-like molecule, Oasl5 in mice. Shibata S, et al. Gene, 2001 Jun 27. PMID 11418248
  2. Gene expression in mouse oocytes and preimplantation embryos: use of suppression subtractive hybridization to identify oocyte- and embryo-specific genes. Zeng F, et al. Biol Reprod, 2003 Jan. PMID 12493692
  3. Structural and functional genomics and evolutionary relationships in the cluster of genes encoding murine 2',5'-oligoadenylate synthetases. Mashimo T, et al. Genomics, 2003 Nov. PMID 14559211
  4. Gene structure of the murine 2'-5'-oligoadenylate synthetase family. Eskildsen S, et al. Cell Mol Life Sci, 2002 Jul. PMID 12222967
  5. The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities. Kristiansen H, et al. J Interferon Cytokine Res, 2011 Jan. PMID 21142819

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC124107

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NOT enables 2'-5'-oligoadenylate synthetase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables 2'-5'-oligoadenylate synthetase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in antiviral innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to interferon-alpha ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to interferon-beta ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in glucose homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in glucose metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of IP-10 production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of chemokine (C-X-C motif) ligand 2 production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of viral genome replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cellular respiration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of monocyte chemotactic protein-1 production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
  
involved_in protein complex oligomerization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of ribonuclease activity ISO
Inferred from Sequence Orthology
more info
  
involved_in response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in surfactant homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in toll-like receptor 3 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in toll-like receptor 4 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
colocalizes_with cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in ribosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
inactive 2'-5' oligoadenylate synthetase 1C
Names
2',5'-oligoadenylate synthetase-like 5
2'-5' oligoadenylate synthetase-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033541.4 → NP_291019.1  inactive 2'-5' oligoadenylate synthetase 1C

    See identical proteins and their annotated locations for NP_291019.1

    Status: PROVISIONAL

    Source sequence(s)
    AC115937
    Consensus CDS
    CCDS19626.1
    UniProtKB/Swiss-Prot
    Q924S2
    UniProtKB/TrEMBL
    Q8K4B5
    Related
    ENSMUSP00000112584.2, ENSMUST00000117193.8
    Conserved Domains (2) summary
    cd05400
    Location:27 → 157
    NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
    pfam10421
    Location:173 → 355
    OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    120938259..120950605 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530120.1 → XP_006530183.1  inactive 2'-5' oligoadenylate synthetase 1C isoform X3

    Conserved Domains (1) summary
    pfam10421
    Location:36 → 218
    OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

  2. XM_036164732.1 → XP_036020625.1  inactive 2'-5' oligoadenylate synthetase 1C isoform X2

    UniProtKB/TrEMBL
    Q8K4B5
    Conserved Domains (2) summary
    pfam10421
    Location:113 → 295
    OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
    cl11966
    Location:1 → 97
    NT_Pol-beta-like; Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins

  3. XM_006530118.2 → XP_006530181.1  inactive 2'-5' oligoadenylate synthetase 1C isoform X1

    UniProtKB/TrEMBL
    Q8K4B5
    Conserved Domains (2) summary
    cd05400
    Location:27 → 157
    NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
    pfam10421
    Location:173 → 292
    OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q924S2.1 GenPept UniProtKB/Swiss-Prot:Q924S2

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