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Actc1 actin, alpha, cardiac muscle 1 [ Mus musculus (house mouse) ]

Gene ID: 11464, updated on 8-Dec-2022

Summary

Official Symbol
Actc1provided by MGI
Official Full Name
actin, alpha, cardiac muscle 1provided by MGI
Primary source
MGI:MGI:87905
See related
Ensembl:ENSMUSG00000068614 AllianceGenome:MGI:87905
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Actc-1
Summary
Predicted to enable ATP binding activity; microfilament motor activity; and myosin binding activity. Acts upstream of or within several processes, including actin-mediated cell contraction; cardiac muscle tissue morphogenesis; and myofibril assembly. Located in I band. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; musculature; and sensory organ. Used to study dilated cardiomyopathy 1R. Human ortholog(s) of this gene implicated in atrial heart septal defect 5; dilated cardiomyopathy; dilated cardiomyopathy 1R; and hypertrophic cardiomyopathy 11. Orthologous to human ACTC1 (actin alpha cardiac muscle 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward heart adult (RPKM 9964.4) See more
Orthologs
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Genomic context

See Actc1 in Genome Data Viewer
Location:
2 E4; 2 57.55 cM
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (113877763..113883356, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (114047282..114052875, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39909 Neighboring gene RIKEN cDNA A530058N18 gene Neighboring gene gap junction protein, delta 2 Neighboring gene RIKEN cDNA C130080G10 gene Neighboring gene predicted gene, 46757 Neighboring gene predicted gene, 54143

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC118715

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables microfilament motor activity ISO
Inferred from Sequence Orthology
more info
 
enables myosin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables myosin binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in I band IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in actin filament ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in sarcomere IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in sarcomere ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
actin, alpha cardiac muscle 1
Names
actin alpha cardiac
alpha-cardiac actin
alphac-actin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009608.4NP_033738.1  actin, alpha cardiac muscle 1

    See identical proteins and their annotated locations for NP_033738.1

    Status: VALIDATED

    Source sequence(s)
    AC133157, AK169165, BY774015
    Consensus CDS
    CCDS16564.1
    UniProtKB/Swiss-Prot
    P68033
    UniProtKB/TrEMBL
    A0A6P5QYT9, A0A8C6G6K0, Q497E4
    Related
    ENSMUSP00000087736.7, ENSMUST00000090269.7
    Conserved Domains (1) summary
    PTZ00281
    Location:4377
    PTZ00281; actin; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    113877763..113883356 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)