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Atp5mc3 ATP synthase membrane subunit c locus 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 114630, updated on 4-Jan-2025

Summary

Official Symbol
Atp5mc3provided by RGD
Official Full Name
ATP synthase membrane subunit c locus 3provided by RGD
Primary source
RGD:620052
See related
EnsemblRapid:ENSRNOG00000001596 AllianceGenome:RGD:620052
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Atp5g3
Summary
Enables ligand-gated channel activity. Involved in several processes, including pore complex assembly; response to (R)-carnitine; and response to muscle stretch. Part of cation channel complex. Human ortholog(s) of this gene implicated in early-onset dystonia and/or spastic paraplegia. Orthologous to human ATP5MC3 (ATP synthase membrane subunit c locus 3). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Heart (RPKM 6718.7), Muscle (RPKM 4018.1) and 7 other tissues See more
Orthologs
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Genomic context

See Atp5mc3 in Genome Data Viewer
Location:
3q23
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (79218014..79220664, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (58810535..58813185, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (60811218..60813903, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486116 Neighboring gene activating transcription factor 2 Neighboring gene uncharacterized LOC120101572 Neighboring gene NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1-like Neighboring gene uncharacterized LOC134478830

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ligand-gated channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables proton transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in pore complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proton motive force-driven ATP synthesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proton motive force-driven ATP synthesis IEA
Inferred from Electronic Annotation
more info
 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in response to (R)-carnitine IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to muscle stretch IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
part_of cation channel complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of proton-transporting ATP synthase complex, coupling factor F(o) IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of proton-transporting ATP synthase complex, coupling factor F(o) IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ATP synthase F(0) complex subunit C3, mitochondrial
Names
ATP synthase lipid-binding protein, mitochondrial
ATP synthase proteolipid P3
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9)
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
ATPase protein 9
ATPase subunit c

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361400.1NP_001348329.1  ATP synthase F(0) complex subunit C3, mitochondrial precursor

    Status: VALIDATED

    Source sequence(s)
    FN800719, JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I6AAH2, F7EW45, Q499S2
    Related
    ENSRNOP00000055032.3, ENSRNOT00000058234.5
    Conserved Domains (1) summary
    MTH00222
    Location:67141
    ATP9; ATP synthase F0 subunit 9; Provisional
  2. NM_001361401.1NP_001348330.1  ATP synthase F(0) complex subunit C3, mitochondrial precursor

    Status: VALIDATED

    Source sequence(s)
    FM058126, JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I6AAH2, F7EW45, Q499S2
    Conserved Domains (1) summary
    MTH00222
    Location:67141
    ATP9; ATP synthase F0 subunit 9; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    79218014..79220664 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_053756.1: Suppressed sequence

    Description
    NM_053756.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.