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Actb actin, beta [ Mus musculus (house mouse) ]

Gene ID: 11461, updated on 17-Jan-2023

Summary

Official Symbol
Actbprovided by MGI
Official Full Name
actin, betaprovided by MGI
Primary source
MGI:MGI:87904
See related
Ensembl:ENSMUSG00000029580 AllianceGenome:MGI:87904
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Actx; beta-actin; E430023M04Rik
Summary
This gene encodes a member of the actin family of proteins. Actins are highly conserved proteins that are among the most abundant proteins in eukaryotic cells and are involved in cell motility, structure, and integrity. Localization, stability, and translation of the transcribed mRNA are regulated through the binding of multiple factors to its 3' UTR sequence. Homozygous knockout mice for this gene exhibit embryonic lethality. Numerous pseudogenes of this gene have been identified in the mouse genome. [provided by RefSeq, Sep 2015]
Expression
Ubiquitous expression in large intestine adult (RPKM 3015.0), spleen adult (RPKM 2803.4) and 28 other tissues See more
Orthologs
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Genomic context

See Actb in Genome Data Viewer
Location:
5 G2; 5 81.8 cM
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (142888870..142892509, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (142903115..142907976, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52793 Neighboring gene F-box and leucine-rich repeat protein 18 Neighboring gene predicted gene, 38733 Neighboring gene fascin actin-bundling protein 1 Neighboring gene VISTA enhancer mm1619 Neighboring gene ring finger protein 216

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables Tat protein binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinesin binding ISO
Inferred from Sequence Orthology
more info
 
enables nitric-oxide synthase binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables structural constituent of postsynaptic actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in adherens junction assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in apical protein localization ISO
Inferred from Sequence Orthology
more info
 
involved_in axonogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cell motility ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to cytochalasin B ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to electrical stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in chromatin remodeling NAS
Non-traceable Author Statement
more info
PubMed 
involved_in establishment or maintenance of cell polarity ISO
Inferred from Sequence Orthology
more info
 
involved_in histone H2A acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in histone H4 acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in histone acetylation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in morphogenesis of a polarized epithelium ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of cyclin-dependent protein kinase activity IC
Inferred by Curator
more info
PubMed 
involved_in negative regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of T cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of cell population proliferation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of double-strand break repair NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of myoblast differentiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of stem cell population maintenance NAS
Non-traceable Author Statement
more info
PubMed 
involved_in postsynaptic actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to adherens junction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of G0 to G1 transition NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of G1/S transition of mitotic cell cycle NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of apoptotic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of double-strand break repair NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of mitotic metaphase/anaphase transition NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of norepinephrine uptake ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of nucleotide-excision repair NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synaptic vesicle endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of synaptic vesicle endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of transepithelial transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of GBAF complex NAS
Non-traceable Author Statement
more info
PubMed 
part_of NuA4 histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
 
part_of RSC-type complex NAS
Non-traceable Author Statement
more info
PubMed 
part_of SWI/SNF complex NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
 
located_in apical junction complex ISO
Inferred from Sequence Orthology
more info
 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
part_of bBAF complex NAS
Non-traceable Author Statement
more info
PubMed 
part_of brahma complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in brush border IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in calyx of Held IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in calyx of Held IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in chromatin NAS
Non-traceable Author Statement
more info
PubMed 
located_in cortical cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in kinetochore NAS
Non-traceable Author Statement
more info
PubMed 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath HDA PubMed 
part_of nBAF complex NAS
Non-traceable Author Statement
more info
PubMed 
part_of npBAF complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in nuclear matrix NAS
Non-traceable Author Statement
more info
PubMed 
part_of nucleosome ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in podosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
 
located_in tight junction ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
actin, cytoplasmic 1
Names
A-X actin-like protein
actin, beta, cytoplasmic
melanoma X-actin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007393.5NP_031419.1  actin, cytoplasmic 1

    See identical proteins and their annotated locations for NP_031419.1

    Status: REVIEWED

    Source sequence(s)
    AC144818, AK142426, AK150711, BY094883, BY155324, BY783897, CX211008
    Consensus CDS
    CCDS19833.1
    UniProtKB/Swiss-Prot
    P60710, Q6ZWM3
    UniProtKB/TrEMBL
    A0A6P5PSI5, B2RRX1
    Related
    ENSMUSP00000098066.5, ENSMUST00000100497.11
    Conserved Domains (1) summary
    PTZ00281
    Location:1375
    PTZ00281; actin; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    142888870..142892509 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)