Actb actin, beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Actbprovided by MGI
Official Full Name: actin, betaprovided by MGI
Primary source: MGI:MGI:87904
See related: Ensembl:ENSMUSG00000029580 AllianceGenome:MGI:87904
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Actx; beta-actin; E430023M04Rik
Summary: This gene encodes a member of the actin family of proteins. Actins are highly conserved proteins that are among the most abundant proteins in eukaryotic cells and are involved in cell motility, structure, and integrity. Localization, stability, and translation of the transcribed mRNA are regulated through the binding of multiple factors to its 3' UTR sequence. Homozygous knockout mice for this gene exhibit embryonic lethality. Numerous pseudogenes of this gene have been identified in the mouse genome. [provided by RefSeq, Sep 2015]
Expression: Ubiquitous expression in large intestine adult (RPKM 3015.0), spleen adult (RPKM 2803.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 81.8 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (142888870..142892509, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (142903115..142907976, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cortactin Contributes to Activity-Dependent Modulation of Spine Actin Dynamics and Spatial Memory Formation.
Title: Cortactin Contributes to Activity-Dependent Modulation of Spine Actin Dynamics and Spatial Memory Formation.
Mitochondria-localized beta-actin is essential for priming innate antiviral immune signaling by regulating IRF3 protein stability.
Title: Mitochondria-localized β-actin is essential for priming innate antiviral immune signaling by regulating IRF3 protein stability.
Our data suggest that targeted disruption of L-plastin increases trabecular bone volume, and phosphorylation of Ser5 in L-plastin in the Lrrk1 signaling pathway may in part contribute to actin assembly in mature osteoclasts.
Title: LRRK1 regulation of actin assembly in osteoclasts involves serine 5 phosphorylation of L-plastin.
In beta-actin null cells, we show evidence that the enhanced TGF-b signaling relies on the active utilization of latent TGF-b1 in the cell culture medium. TGF-b signaling activation contributes to the elevated reactive oxygen species production, which is likely mediated by the upregulation of Nox4.
Title: Elevated transforming growth factor β signaling activation in β-actin-knockout mouse embryonic fibroblasts enhances myofibroblast features.
our work reveals fundamental differences in the role of the cortical beta-actin cytoskeleton in mature muscle compared with cell culture
Title: β-Actin shows limited mobility and is required only for supraphysiological insulin-stimulated glucose transport in young adult soleus muscle.
Data, including data from studies using knockout mice, suggest that Actb and Actg1 are enriched in isolated membrane preparations from skeletal muscle which represent interface between mitochondria and sarco-endoplasmic reticulum; these structures appear to be important in signaling, mitochondrial dynamics, and muscle relaxation. (Actb = beta actin cytoplasmic 1; Actg1 = actin gamma cytoplasmic 1)
Title: Impaired muscle relaxation and mitochondrial fission associated with genetic ablation of cytoplasmic actin isoforms.
Essential nucleotide- and protein-dependent functions of Actb/beta-actin.
Title: Essential nucleotide- and protein-dependent functions of Actb/β-actin.
These results suggest a a novel genome-wide mechanism where the polymerase-associated beta-actin synergizes with NM1 to coordinate permissive chromatin with Pol I transcription, cell growth, and proliferation.
Title: In β-actin knockouts, epigenetic reprogramming and rDNA transcription inactivation lead to growth and proliferation defects.
Two actin isoforms, beta- and gamma-actin, are crucial for slow, rapid, bulk, and overshoot endocytosis at large calyx-type synapses, and for slow endocytosis and bulk endocytosis at small hippocampal synapses.
Title: Actin Is Crucial for All Kinetically Distinguishable Forms of Endocytosis at Synapses.
Melatonin treatment for 1 h increased monomeric actin and decreased polymeric actin.
Title: Microarray and gene co-expression analysis reveals that melatonin attenuates immune responses and modulates actin rearrangement in macrophages.

Submit: New GeneRIF Correction See all GeneRIFs (37)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (20) 1 citation
Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC156124P2 (e-PCR)
- UniSTS:271360

PMC200947P1 (e-PCR)
- UniSTS:271873

PMC33181P2 (e-PCR)
- UniSTS:273155

PMC117780P1 (e-PCR)
- UniSTS:270340

PMC117781P1 (e-PCR)
- UniSTS:270341

PMC98352P1 (e-PCR)
- UniSTS:273669

PMC129743P3 (e-PCR)
- UniSTS:270598

PMC137757P2 (e-PCR)
- UniSTS:270854

PMC137792P1 (e-PCR)
- UniSTS:270855

PMC33279P1 (e-PCR)
- UniSTS:273159

PMC129788P1 (e-PCR)
- UniSTS:270602

mActb (e-PCR)
- UniSTS:514570

PMC138011P1 (e-PCR)
- UniSTS:270859

PMC201106P1 (e-PCR)
- UniSTS:271883

Acat1 (e-PCR), detects polymorphism
- UniSTS:546573

PMC138261P1 (e-PCR)
- UniSTS:270864

PMC340938P1 (e-PCR)
- UniSTS:273170

PMC340938P4 (e-PCR)
- UniSTS:273172

PMC104029P1 (e-PCR)
- UniSTS:270101

PMC150974P1 (e-PCR)
- UniSTS:271127

PMC151001P2 (e-PCR)
- UniSTS:271130

PMC99880P2 (e-PCR)
- UniSTS:273691

aa658676 (e-PCR)
- UniSTS:186920

PMC107891P1 (e-PCR)
- UniSTS:270127

PMC84911P1 (e-PCR)
- UniSTS:273455

PMC139793P1 (e-PCR)
- UniSTS:270897

PMC122089P1 (e-PCR)
- UniSTS:270386

PMC180915P1 (e-PCR)
- UniSTS:271667

PMC108483P1 (e-PCR)
- UniSTS:270139

PMC108612P1 (e-PCR)
- UniSTS:270141

PMC85361P1 (e-PCR)
- UniSTS:273471

PMC133768P1 (e-PCR)
- UniSTS:270660

PMC122623P1 (e-PCR)
- UniSTS:270405

Actb (e-PCR), detects polymorphism
- UniSTS:516679

PMC18465P1 (e-PCR)
- UniSTS:271688

PMC151804P4 (e-PCR)
- UniSTS:271178

PMC133829P1 (e-PCR)
- UniSTS:270667

PMC151817P1 (e-PCR)
- UniSTS:271183

PMC122924P2 (e-PCR)
- UniSTS:270416

Actb (e-PCR), detects polymorphism
- UniSTS:496720

PMC207566P4 (e-PCR)
- UniSTS:271957

PMC85795P4 (e-PCR)
- UniSTS:273493

PMC23951P1 (e-PCR)
- UniSTS:272215

PMC350549P3 (e-PCR)
- UniSTS:273239

PMC23952P1 (e-PCR)
- UniSTS:272216

PMC240671P1 (e-PCR)
- UniSTS:272217

PMC109653P1 (e-PCR)
- UniSTS:270174

PMC109669P1 (e-PCR)
- UniSTS:270176

PMC86032P2 (e-PCR)
- UniSTS:273511

PMC110143P1 (e-PCR)
- UniSTS:270184

PMC187403P1 (e-PCR)
- UniSTS:271725

PMC110672P1 (e-PCR)
- UniSTS:270192

PMC133998P8 (e-PCR)
- UniSTS:270713

PMC356969P12 (e-PCR)
- UniSTS:273274

PMC152551P1 (e-PCR)
- UniSTS:271229

PMC209527P1 (e-PCR)
- UniSTS:271999

PMC20960P1 (e-PCR)
- UniSTS:272003

PMC86650P1 (e-PCR)
- UniSTS:273539

PMC19354P1 (e-PCR)
- UniSTS:271749

PMC193670P1 (e-PCR)
- UniSTS:271752

PMC24561P1 (e-PCR)
- UniSTS:272264

PMC21071P1 (e-PCR)
- UniSTS:272011

PMC24644P4 (e-PCR)
- UniSTS:272270

PMC24644P5 (e-PCR)
- UniSTS:272271

PMC86716P1 (e-PCR)
- UniSTS:273551

PMC125253P1 (e-PCR)
- UniSTS:270485

PMC24942P1 (e-PCR)
- UniSTS:272277

LOC345651 (e-PCR)
- UniSTS:265879

PMC145386P1 (e-PCR)
- UniSTS:270999

PMC30411P1 (e-PCR)
- UniSTS:272535

PMC125345P1 (e-PCR)
- UniSTS:270489

PMC212730P1 (e-PCR)
- UniSTS:272026

PMC37512P3 (e-PCR)
- UniSTS:273307

PMC87052P1 (e-PCR)
- UniSTS:273574

PMC262340P2 (e-PCR)
- UniSTS:272295

PMC125678P1 (e-PCR)
- UniSTS:270504

PMC148838P1 (e-PCR)
- UniSTS:271023

PMC305683P4 (e-PCR)
- UniSTS:272560

PMC135783P1 (e-PCR)
- UniSTS:270773

PMC149351P1 (e-PCR)
- UniSTS:271029

PMC114224P1 (e-PCR)
- UniSTS:270262

PMC114236P1 (e-PCR)
- UniSTS:270264

PMC305873P2 (e-PCR)
- UniSTS:272568

PMC21385P1 (e-PCR)
- UniSTS:272059

PMC196458P4 (e-PCR)
- UniSTS:271808

PMC317352P1 (e-PCR)
- UniSTS:273088

PMC136359P1 (e-PCR)
- UniSTS:270796

PMC115141P1 (e-PCR)
- UniSTS:270285

PMC154439P1 (e-PCR)
- UniSTS:271310

RI01350 (e-PCR)
- UniSTS:463064

Actb (e-PCR), detects polymorphism
- UniSTS:141016

Actb-rs1 (e-PCR), detects polymorphism
- UniSTS:141017

PMC26753P1 (e-PCR)
- UniSTS:272350

PMC96811P1 (e-PCR)
- UniSTS:273633

PMC101699P1 (e-PCR)
- UniSTS:270062

PMC97307P1 (e-PCR)
- UniSTS:273648

PMC224995P1 (e-PCR)
- UniSTS:272113

PMC117216P3 (e-PCR)
- UniSTS:270322

PMC97445P1 (e-PCR)
- UniSTS:273650

STSGM007690 (e-PCR)
- UniSTS:242675

PMC102052P1 (e-PCR)
- UniSTS:270068

PMC97559P2 (e-PCR)
- UniSTS:273652

PMC97568P1 (e-PCR)
- UniSTS:273653

PMC22515P2 (e-PCR)
- UniSTS:272118

PMC117352P1 (e-PCR)
- UniSTS:270329

PMC102156P1 (e-PCR)
- UniSTS:270076

PMC275467P1 (e-PCR)
- UniSTS:272382

PMC129447P1 (e-PCR)
- UniSTS:270591

Homology

Homologs of the Actb gene: The Actb gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, fruit fly, mosquito, rice, and frog.
Orthologs from Annotation Pipeline: 424 organisms have orthologs with human gene Actb
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables Tat protein binding	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinesin binding	ISO Inferred from Sequence Orthology more info
enables nitric-oxide synthase binding	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables structural constituent of postsynaptic actin cytoskeleton	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adherens junction assembly	ISO Inferred from Sequence Orthology more info
involved_in apical protein localization	ISO Inferred from Sequence Orthology more info
involved_in axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell motility	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cytochalasin B	ISO Inferred from Sequence Orthology more info
involved_in cellular response to electrical stimulus	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	NAS Non-traceable Author Statement more info	PubMed
involved_in establishment or maintenance of cell polarity	ISO Inferred from Sequence Orthology more info
involved_in histone H2A acetylation	ISO Inferred from Sequence Orthology more info
involved_in histone H4 acetylation	ISO Inferred from Sequence Orthology more info
involved_in histone acetylation	NAS Non-traceable Author Statement more info	PubMed
involved_in morphogenesis of a polarized epithelium	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of cyclin-dependent protein kinase activity	IC Inferred by Curator more info	PubMed
involved_in negative regulation of protein binding	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of T cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of cell population proliferation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of double-strand break repair	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myoblast differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of stem cell population maintenance	NAS Non-traceable Author Statement more info	PubMed
involved_in postsynaptic actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in protein localization to adherens junction	ISO Inferred from Sequence Orthology more info
involved_in regulation of G0 to G1 transition	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of G1/S transition of mitotic cell cycle	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of apoptotic process	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of double-strand break repair	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of mitotic metaphase/anaphase transition	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of norepinephrine uptake	ISO Inferred from Sequence Orthology more info
involved_in regulation of nucleotide-excision repair	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic vesicle endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic vesicle endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of transepithelial transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of GBAF complex	NAS Non-traceable Author Statement more info	PubMed
part_of NuA4 histone acetyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of RSC-type complex	NAS Non-traceable Author Statement more info	PubMed
part_of SWI/SNF complex	NAS Non-traceable Author Statement more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in apical junction complex	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
part_of bBAF complex	NAS Non-traceable Author Statement more info	PubMed
part_of brahma complex	NAS Non-traceable Author Statement more info	PubMed
located_in brush border	IDA Inferred from Direct Assay more info	PubMed
is_active_in calyx of Held	IDA Inferred from Direct Assay more info	PubMed
is_active_in calyx of Held	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in chromatin	NAS Non-traceable Author Statement more info	PubMed
located_in cortical cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in kinetochore	NAS Non-traceable Author Statement more info	PubMed
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in myelin sheath	HDA more info	PubMed
part_of nBAF complex	NAS Non-traceable Author Statement more info	PubMed
part_of npBAF complex	NAS Non-traceable Author Statement more info	PubMed
located_in nuclear matrix	NAS Non-traceable Author Statement more info	PubMed
part_of nucleosome	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in podosome	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info
located_in stress fiber	ISO Inferred from Sequence Orthology more info
located_in tight junction	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: actin, cytoplasmic 1

Names: A-X actin-like protein; actin, beta, cytoplasmic; melanoma X-actin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.