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Dpp3 dipeptidylpeptidase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 114591, updated on 18-Apr-2019

Summary

Official Symbol
Dpp3provided by RGD
Official Full Name
dipeptidylpeptidase 3provided by RGD
Primary source
RGD:621127
See related
Ensembl:ENSRNOG00000031485
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
catalyzes the release of an N-terminal dipeptide from a peptide of four or more residues; catalyzes the hydrolysis of Arg-Arg-2-naphthylamide; binds zinc [RGD, Feb 2006]
Expression
Biased expression in Liver (RPKM 171.3), Kidney (RPKM 150.6) and 9 other tissues See more
Orthologs

Genomic context

See Dpp3 in Genome Data Viewer
Location:
1q43
Exon count:
20
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (220166124..220189762, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (227097122..227120699, complement)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene zinc finger, DHHC-type containing 24 Neighboring gene Bardet-Biedl syndrome 1 Neighboring gene pellino E3 ubiquitin protein ligase family member 3 Neighboring gene mitochondrial ribosomal protein L11

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

General gene information

Markers

Homology

Clone Names

  • MGC124585

Gene Ontology Provided by RGD

Function Evidence Code Pubs
dipeptidyl-peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dipeptidyl-peptidase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
proteolysis ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
nuclear speck IEA
Inferred from Electronic Annotation
more info
 
nuclear speck ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dipeptidyl peptidase 3
Names
DPP III
dipeptidyl aminopeptidase III
dipeptidyl arylamidase III
dipeptidyl peptidase III
dipeptidyl-peptidase 3
dipeptidylpeptidase III
enkephalinase B
NP_446200.1
XP_006230695.1
XP_017444144.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053748.1NP_446200.1  dipeptidyl peptidase 3

    See identical proteins and their annotated locations for NP_446200.1

    Status: PROVISIONAL

    Source sequence(s)
    D89340
    UniProtKB/Swiss-Prot
    O55096
    Related
    ENSRNOP00000026968.5, ENSRNOT00000026968.6
    Conserved Domains (1) summary
    pfam03571
    Location:147704
    Peptidase_M49; Peptidase family M49

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    220166124..220189762 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006230633.3XP_006230695.1  dipeptidyl peptidase 3 isoform X1

    See identical proteins and their annotated locations for XP_006230695.1

    UniProtKB/Swiss-Prot
    O55096
    Conserved Domains (1) summary
    pfam03571
    Location:147704
    Peptidase_M49; Peptidase family M49
  2. XM_017588655.1XP_017444144.1  dipeptidyl peptidase 3 isoform X2

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    199744187..199768442 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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