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Zbtb21 zinc finger and BTB domain containing 21 [ Mus musculus (house mouse) ]

Gene ID: 114565, updated on 8-Dec-2022

Summary

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Official Symbol
Zbtb21provided by MGI
Official Full Name
zinc finger and BTB domain containing 21provided by MGI
Primary source
MGI:MGI:1927240
See related
Ensembl:ENSMUSG00000046962 AllianceGenome:MGI:1927240
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zfp295; Znf295; mKIAA1227; 5430437K12Rik; B430213I24Rik
Summary
Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; POZ domain binding activity; and methyl-CpG binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in brain; early conceptus; genitourinary system; and surface ectoderm. Orthologous to human ZBTB21 (zinc finger and BTB domain containing 21). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 2.0), limb E14.5 (RPKM 1.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zbtb21 in Genome Data Viewer
Location:
16; 16 C4
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (97746993..97763850, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (97945795..97962627, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene PR domain containing 15 Neighboring gene C2 calcium-dependent domain containing 2 Neighboring gene microRNA 6964 Neighboring gene predicted gene, 53924 Neighboring gene RIKEN cDNA C030010L15 gene Neighboring gene RIKEN cDNA B230307C23 gene Neighboring gene vomeronasal 2, receptor, pseudogene 112

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ts65Dn -- localization of the translocation breakpoint and trisomic gene content in a mouse model for Down syndrome. Akeson EC, et al. Cytogenet Cell Genet, 2001. PMID 11528125
  2. Evolutionary breakpoints on human chromosome 21. Davisson MT, et al. Genomics, 2001 Nov. PMID 11707078
  3. ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Medeiros de Araújo JA, et al. Development, 2021 Aug 15. PMID 34351428, Free PMC Article
  4. A gene expression map of human chromosome 21 orthologues in the mouse. Gitton Y, et al. Nature, 2002 Dec 5. PMID 12466855
  5. Human chromosome 21 gene expression atlas in the mouse. Reymond A, et al. Nature, 2002 Dec 5. PMID 12466854

See all (24) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables POZ domain binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables methyl-CpG binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 21
Names
zinc finger protein 295

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081684.2 → NP_001075153.1  zinc finger and BTB domain-containing protein 21 isoform 2

    See identical proteins and their annotated locations for NP_001075153.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks part of the 5' coding region and uses a downstream in-frame start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC226122, AK034057
    Consensus CDS
    CCDS37420.1
    UniProtKB/TrEMBL
    E9Q3R9, Q8CC25
    Related
    ENSMUSP00000068283.8, ENSMUST00000063605.15
    Conserved Domains (5) summary
    sd00017
    Location:551 → 572
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:911 → 931
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:673 → 695
    zf-C2H2; Zinc finger, C2H2 type
    cd18209
    Location:12 → 123
    BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
    pfam18450
    Location:748 → 775
    zf_C2H2_6; Zinc Finger domain

  2. NM_001081685.2 → NP_001075154.1  zinc finger and BTB domain-containing protein 21 isoform 3

    See identical proteins and their annotated locations for NP_001075154.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses alternate splicing in the coding region but maintains the reading frame compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC226122, AK031118, AK034057
    Consensus CDS
    CCDS37419.1
    UniProtKB/TrEMBL
    G3X9A3, Q8BSP5, Q8CC25
    Related
    ENSMUSP00000052127.8, ENSMUST00000052089.9
    Conserved Domains (4) summary
    sd00019
    Location:739 → 759
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18209
    Location:40 → 151
    BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
    pfam00096
    Location:871 → 893
    zf-C2H2; Zinc finger, C2H2 type
    pfam18450
    Location:576 → 603
    zf_C2H2_6; Zinc Finger domain

  3. NM_001320385.1 → NP_001307314.1  zinc finger and BTB domain-containing protein 21 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks part of the 5' coding region, uses a downstream in-frame start codon, and uses alternate splicing in the coding region, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AC226122, AK034057
    Consensus CDS
    CCDS88980.1
    UniProtKB/TrEMBL
    A0A6P7QA81, Q80XC5, Q8CC25
    Related
    ENSMUSP00000156033.2, ENSMUST00000232187.2
    Conserved Domains (3) summary
    sd00019
    Location:225 → 245
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl38908
    Location:12 → 53
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam18450
    Location:62 → 89
    zf_C2H2_6; Zinc Finger domain

  4. NM_175428.4 → NP_780637.2  zinc finger and BTB domain-containing protein 21 isoform 1

    See identical proteins and their annotated locations for NP_780637.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC226122, AK034057
    Consensus CDS
    CCDS37418.1
    UniProtKB/TrEMBL
    E9Q444, Q8CC25
    Related
    ENSMUSP00000109363.3, ENSMUST00000113734.9
    Conserved Domains (6) summary
    sd00017
    Location:579 → 600
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:939 → 959
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18209
    Location:40 → 151
    BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
    pfam00096
    Location:701 → 723
    zf-C2H2; Zinc finger, C2H2 type
    pfam18450
    Location:776 → 803
    zf_C2H2_6; Zinc Finger domain
    cd20908
    Location:576 → 629
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    97746993..97763850 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159740.1 → XP_036015633.1  zinc finger and BTB domain-containing protein 21 isoform X3

    UniProtKB/TrEMBL
    G3X9A3
    Conserved Domains (4) summary
    sd00019
    Location:739 → 759
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18209
    Location:40 → 151
    BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
    pfam00096
    Location:871 → 893
    zf-C2H2; Zinc finger, C2H2 type
    pfam18450
    Location:576 → 603
    zf_C2H2_6; Zinc Finger domain

  2. XM_006522858.5 → XP_006522921.1  zinc finger and BTB domain-containing protein 21 isoform X1

    See identical proteins and their annotated locations for XP_006522921.1

    UniProtKB/TrEMBL
    E9Q444
    Conserved Domains (6) summary
    sd00017
    Location:579 → 600
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:939 → 959
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18209
    Location:40 → 151
    BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
    pfam00096
    Location:701 → 723
    zf-C2H2; Zinc finger, C2H2 type
    pfam18450
    Location:776 → 803
    zf_C2H2_6; Zinc Finger domain
    cd20908
    Location:576 → 629
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  3. XM_006522861.5 → XP_006522924.1  zinc finger and BTB domain-containing protein 21 isoform X8

    UniProtKB/TrEMBL
    A0A6P7QL59
    Conserved Domains (3) summary
    sd00019
    Location:253 → 273
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl38908
    Location:40 → 81
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam18450
    Location:90 → 117
    zf_C2H2_6; Zinc Finger domain

  4. XM_030248925.1 → XP_030104785.1  zinc finger and BTB domain-containing protein 21 isoform X4

    UniProtKB/TrEMBL
    Q8R0A4
    Conserved Domains (4) summary
    sd00019
    Location:711 → 731
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:843 → 865
    zf-C2H2; Zinc finger, C2H2 type
    cd18209
    Location:12 → 123
    BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
    pfam18450
    Location:548 → 575
    zf_C2H2_6; Zinc Finger domain

  5. XM_030248928.2 → XP_030104788.1  zinc finger and BTB domain-containing protein 21 isoform X9

    UniProtKB/TrEMBL
    A0A6P7QA81, Q80XC5
    Conserved Domains (3) summary
    sd00019
    Location:225 → 245
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl38908
    Location:12 → 53
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam18450
    Location:62 → 89
    zf_C2H2_6; Zinc Finger domain

  6. XM_030248924.1 → XP_030104784.1  zinc finger and BTB domain-containing protein 21 isoform X3

    UniProtKB/TrEMBL
    G3X9A3
    Conserved Domains (4) summary
    sd00019
    Location:739 → 759
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18209
    Location:40 → 151
    BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
    pfam00096
    Location:871 → 893
    zf-C2H2; Zinc finger, C2H2 type
    pfam18450
    Location:576 → 603
    zf_C2H2_6; Zinc Finger domain

  7. XM_030248927.2 → XP_030104787.1  zinc finger and BTB domain-containing protein 21 isoform X8

    UniProtKB/TrEMBL
    A0A6P7QL59
    Conserved Domains (3) summary
    sd00019
    Location:253 → 273
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl38908
    Location:40 → 81
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam18450
    Location:90 → 117
    zf_C2H2_6; Zinc Finger domain

  8. XM_036159738.1 → XP_036015631.1  zinc finger and BTB domain-containing protein 21 isoform X1

    UniProtKB/TrEMBL
    E9Q444
    Conserved Domains (6) summary
    sd00017
    Location:579 → 600
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:939 → 959
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18209
    Location:40 → 151
    BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
    pfam00096
    Location:701 → 723
    zf-C2H2; Zinc finger, C2H2 type
    pfam18450
    Location:776 → 803
    zf_C2H2_6; Zinc Finger domain
    cd20908
    Location:576 → 629
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  9. XM_036159742.1 → XP_036015635.1  zinc finger and BTB domain-containing protein 21 isoform X6

    Conserved Domains (5) summary
    sd00017
    Location:245 → 266
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:605 → 625
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl38908
    Location:12 → 52
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam18450
    Location:442 → 469
    zf_C2H2_6; Zinc Finger domain
    cd20908
    Location:242 → 295
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  10. XM_036159743.1 → XP_036015636.1  zinc finger and BTB domain-containing protein 21 isoform X7

    Conserved Domains (3) summary
    sd00019
    Location:433 → 453
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl38908
    Location:40 → 80
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam18450
    Location:270 → 297
    zf_C2H2_6; Zinc Finger domain

  11. XM_036159741.1 → XP_036015634.1  zinc finger and BTB domain-containing protein 21 isoform X5

    Conserved Domains (4) summary
    sd00017
    Location:273 → 294
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:633 → 653
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl38908
    Location:40 → 80
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam18450
    Location:470 → 497
    zf_C2H2_6; Zinc Finger domain

  12. XM_006522860.5 → XP_006522923.1  zinc finger and BTB domain-containing protein 21 isoform X2

    See identical proteins and their annotated locations for XP_006522923.1

    UniProtKB/TrEMBL
    E9Q3R9
    Conserved Domains (5) summary
    sd00017
    Location:551 → 572
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:911 → 931
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:673 → 695
    zf-C2H2; Zinc finger, C2H2 type
    cd18209
    Location:12 → 123
    BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
    pfam18450
    Location:748 → 775
    zf_C2H2_6; Zinc Finger domain

  13. XM_036159739.1 → XP_036015632.1  zinc finger and BTB domain-containing protein 21 isoform X1

    UniProtKB/TrEMBL
    E9Q444
    Conserved Domains (6) summary
    sd00017
    Location:579 → 600
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:939 → 959
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18209
    Location:40 → 151
    BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
    pfam00096
    Location:701 → 723
    zf-C2H2; Zinc finger, C2H2 type
    pfam18450
    Location:776 → 803
    zf_C2H2_6; Zinc Finger domain
    cd20908
    Location:576 → 629
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  14. XM_030248926.2 → XP_030104786.1  zinc finger and BTB domain-containing protein 21 isoform X4

    UniProtKB/TrEMBL
    Q8R0A4
    Conserved Domains (4) summary
    sd00019
    Location:711 → 731
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:843 → 865
    zf-C2H2; Zinc finger, C2H2 type
    cd18209
    Location:12 → 123
    BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
    pfam18450
    Location:548 → 575
    zf_C2H2_6; Zinc Finger domain

  15. XM_030248923.2 → XP_030104783.1  zinc finger and BTB domain-containing protein 21 isoform X1

    UniProtKB/TrEMBL
    E9Q444
    Conserved Domains (6) summary
    sd00017
    Location:579 → 600
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:939 → 959
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18209
    Location:40 → 151
    BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
    pfam00096
    Location:701 → 723
    zf-C2H2; Zinc finger, C2H2 type
    pfam18450
    Location:776 → 803
    zf_C2H2_6; Zinc Finger domain
    cd20908
    Location:576 → 629
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
Nucleotide Protein Strain
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