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Arhgef7 Rho guanine nucleotide exchange factor 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 114559, updated on 22-Nov-2020

Summary

Official Symbol
Arhgef7provided by RGD
Official Full Name
Rho guanine nucleotide exchange factor 7provided by RGD
Primary source
RGD:620624
See related
Ensembl:ENSRNOG00000012934
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
P85spr; Pak3bp
Summary
Rac/Cdc42-specific guanine nucleotide exchange factor; mediates bFGF-induced neurite outgrowth [RGD, Feb 2006]
Expression
Biased expression in Heart (RPKM 45.3), Lung (RPKM 43.8) and 9 other tissues See more
Orthologs

Genomic context

See Arhgef7 in Genome Data Viewer
Location:
16q12.5
Exon count:
24
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (83006732..83117065, complement)
106 current Rn_Celera (GCF_000002265.2) 16 AC_000084.1 (75472865..75551301, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 16 NC_005115.3 (82479277..82605606, complement)

Chromosome 16 - NC_005115.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553495 Neighboring gene testis expressed 29 Neighboring gene ankyrin repeat domain 10 Neighboring gene inhibitor of growth family, member 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Golgi organization ISO
Inferred from Sequence Orthology
more info
 
astrocyte cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
hematopoietic progenitor cell differentiation IEA
Inferred from Electronic Annotation
more info
 
hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
lamellipodium assembly IEA
Inferred from Electronic Annotation
more info
 
lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
 
lamellipodium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of growth hormone secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of growth hormone secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of lamellipodium morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of protein binding IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
positive regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
PubMed 
postsynaptic actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
presynaptic actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
presynaptic actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of GTP binding ISO
Inferred from Sequence Orthology
more info
 
small GTPase mediated signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
GABA-ergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
GABA-ergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell cortex IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
cytosol TAS
Traceable Author Statement
more info
 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
growth cone IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium IEA
Inferred from Electronic Annotation
more info
 
lamellipodium ISO
Inferred from Sequence Orthology
more info
 
lamellipodium ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
ruffle IEA
Inferred from Electronic Annotation
more info
 
storage vacuole IEA
Inferred from Electronic Annotation
more info
 
storage vacuole ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
rho guanine nucleotide exchange factor 7
Names
PAK-interacting exchange factor beta
Rho guanine nucleotide exchange factor (GEF) 7
beta-Pix

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113521.1NP_001106993.1  rho guanine nucleotide exchange factor 7 isoform a

    See identical proteins and their annotated locations for NP_001106993.1

    Status: VALIDATED

    Source sequence(s)
    BC131844, BM390964, CB792685
    UniProtKB/TrEMBL
    A3KMH4, Q52NK0
    Related
    ENSRNOP00000043761.5, ENSRNOT00000043449.6
    Conserved Domains (6) summary
    cd12061
    Location:1063
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:320400
    PH; PH domain
    pfam16523
    Location:616702
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:456554
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
  2. NM_001113522.1NP_001106994.1  rho guanine nucleotide exchange factor 7 isoform b

    See identical proteins and their annotated locations for NP_001106994.1

    Status: VALIDATED

    Source sequence(s)
    AF044673, BC131844, BM390964, CB792685
    UniProtKB/Swiss-Prot
    O55043
    UniProtKB/TrEMBL
    A3KMH4
    Related
    ENSRNOP00000017947.4, ENSRNOT00000017947.4
    Conserved Domains (6) summary
    cd12061
    Location:1063
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:320400
    PH; PH domain
    pfam16523
    Location:557643
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:456554
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
  3. NM_053740.2NP_446192.2  rho guanine nucleotide exchange factor 7 isoform c

    See identical proteins and their annotated locations for NP_446192.2

    Status: VALIDATED

    Source sequence(s)
    AY034823, BC131844
    UniProtKB/TrEMBL
    A3KMH4, Q923I5
    Conserved Domains (5) summary
    cd12061
    Location:1063
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:320400
    PH; PH domain
    pfam16614
    Location:456554
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005115.4 Reference Rnor_6.0 Primary Assembly

    Range
    83006732..83117065 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008771380.1XP_008769602.1  rho guanine nucleotide exchange factor 7 isoform X4

    See identical proteins and their annotated locations for XP_008769602.1

    UniProtKB/TrEMBL
    Q52NK0
    Conserved Domains (6) summary
    cd12061
    Location:1063
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:320400
    PH; PH domain
    pfam16523
    Location:616702
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:456554
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
  2. XM_008771379.1XP_008769601.1  rho guanine nucleotide exchange factor 7 isoform X4

    See identical proteins and their annotated locations for XP_008769601.1

    UniProtKB/TrEMBL
    Q52NK0
    Conserved Domains (6) summary
    cd12061
    Location:1063
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:320400
    PH; PH domain
    pfam16523
    Location:616702
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:456554
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
  3. XM_008771378.2XP_008769600.1  rho guanine nucleotide exchange factor 7 isoform X3

    Conserved Domains (7) summary
    cd12061
    Location:107160
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:191368
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:399497
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:417497
    PH; PH domain
    pfam16523
    Location:638724
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:516576
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16615
    Location:57103
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
  4. XM_008771376.2XP_008769598.1  rho guanine nucleotide exchange factor 7 isoform X1

    Conserved Domains (7) summary
    cd12061
    Location:107160
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:191368
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:399497
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:417497
    PH; PH domain
    pfam16523
    Location:713799
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:553651
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16615
    Location:57103
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
  5. XM_008771377.2XP_008769599.1  rho guanine nucleotide exchange factor 7 isoform X2

    Conserved Domains (7) summary
    cd12061
    Location:107160
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:191368
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:399497
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:417497
    PH; PH domain
    pfam16523
    Location:654740
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:553651
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16615
    Location:57103
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
  6. XM_017599975.1XP_017455464.1  rho guanine nucleotide exchange factor 7 isoform X5

  7. XM_017599976.1XP_017455465.1  rho guanine nucleotide exchange factor 7 isoform X6

Alternate Rn_Celera

Genomic

  1. AC_000084.1 Alternate Rn_Celera

    Range
    75472865..75551301 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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