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pklr pyruvate kinase L/R [ Danio rerio (zebrafish) ]

Gene ID: 114551, updated on 19-May-2025
Official Symbol
pklrprovided by ZNC
Official Full Name
pyruvate kinase L/Rprovided by ZNC
Primary source
ZFIN:ZDB-GENE-010907-1
See related
Ensembl:ENSDARG00000042010 AllianceGenome:ZFIN:ZDB-GENE-010907-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fd15e01; wu:fi37e08
Summary
Predicted to enable pyruvate kinase activity. Acts upstream of or within liver development. Predicted to be active in cytoplasm. Is expressed in digestive system; female organism; heart; male organism; and muscle. Human ortholog(s) of this gene implicated in Gaucher's disease; congenital nonspherocytic hemolytic anemia; congenital nonspherocytic hemolytic anemia 2; malaria; and type 2 diabetes mellitus. Orthologous to human PKLR (pyruvate kinase L/R). [provided by Alliance of Genome Resources, May 2025]
Orthologs
all
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See pklr in Genome Data Viewer
Location:
chromosome: 16
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 16 NC_133191.1 (59412425..59421063, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 16 NC_007127.7 (54450407..54458866, complement)

Chromosome 16 - NC_133191.1Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 7B Neighboring gene uncharacterized LOC101882339 Neighboring gene cytochrome P450, family 11, subfamily C, polypeptide 1 Neighboring gene CDC-like kinase 2b

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Study on the signaling pathways involved in the anti-hyperglycemic effect of raspberry ketone on zebrafish using integrative transcriptome and metabolome analyses. Zhu X, et al. Food Funct, 2024 Sep 16. PMID 39189875
  2. Programming effects of high-carbohydrate feeding of larvae on adult glucose metabolism in zebrafish, Danio rerio. Fang L, et al. Br J Nutr, 2014 Mar 14. PMID 24112146
  3. Dose-dependent transcriptomic responses of zebrafish eleutheroembryos to Bisphenol A. Martínez R, et al. Environ Pollut, 2018 Dec. PMID 30248606
  4. Conserved glucokinase regulation in zebrafish confirms therapeutic utility for pharmacologic modulation in diabetes. Schmitner N, et al. Commun Biol, 2024 Nov 23. PMID 39580550, Free PMC Article
  5. Shared acquired genomic changes in zebrafish and human T-ALL. Rudner LA, et al. Oncogene, 2011 Oct 13. PMID 21552289, Free PMC Article

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables potassium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables pyruvate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyruvate kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to insulin stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within glycolytic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within liver development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
pyruvate kinase PKLR
Names
pyruvate kinase, liver and RBC
NP_958446.1
XP_021322272.1
XP_068069969.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201289.1 → NP_958446.1  pyruvate kinase PKLR

    See identical proteins and their annotated locations for NP_958446.1

    Status: PROVISIONAL

    Source sequence(s)
    BC055561
    UniProtKB/TrEMBL
    Q7SXK3
    Related
    ENSDARP00000069759.5, ENSDART00000075275.6
    Conserved Domains (2) summary
    cd00288
    Location:48 → 537
    Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
    TIGR01064
    Location:49 → 533
    pyruv_kin; pyruvate kinase

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133191.1 Reference GRCz12tu Primary Assembly

    Range
    59412425..59421063 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021466597.2 → XP_021322272.1  pyruvate kinase PKLR isoform X1

    UniProtKB/TrEMBL
    A0A8M9NZ14
    Conserved Domains (1) summary
    cd00288
    Location:37 → 526
    Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...

  2. XM_068213868.2 → XP_068069969.1  pyruvate kinase PKLR isoform X2

    UniProtKB/TrEMBL
    A0AB32T4X3
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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