Format

Send to:

Choose Destination

Klf4 Kruppel like factor 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 114505, updated on 6-Jan-2019

Summary

Official Symbol
Klf4provided by RGD
Official Full Name
Kruppel like factor 4provided by RGD
Primary source
RGD:621445
See related
Ensembl:ENSRNOG00000016299
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
GKLF
Summary
a transcription factor that works with Sp1 to activate the Laminin gamma1 chain gene [RGD, Feb 2006]
Expression
Biased expression in Lung (RPKM 146.0), Heart (RPKM 78.5) and 8 other tissues See more
Orthologs

Genomic context

See Klf4 in Genome Data Viewer
Location:
5q24
Exon count:
5
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (72283311..72287669, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 5 NC_005104.3 (76447643..76452001, complement)

Chromosome 5 - NC_005104.4Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene RAD23 homolog B, nucleotide excision repair protein Neighboring gene similar to ribosomal protein S18 Neighboring gene uncharacterized LOC102553326

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC93286

Gene Ontology Provided by RGD

Function Evidence Code Pubs
DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II proximal promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
beta-catenin binding IEA
Inferred from Electronic Annotation
more info
 
beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
histone deacetylase binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphatidylinositol 3-kinase regulator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
promoter-specific chromatin binding IEA
Inferred from Electronic Annotation
more info
 
promoter-specific chromatin binding ISO
Inferred from Sequence Orthology
more info
 
proximal promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcription cofactor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
cell differentiation ISO
Inferred from Sequence Orthology
more info
 
cellular response to cycloheximide IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to hydrogen peroxide IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to laminar fluid shear stress IEA
Inferred from Electronic Annotation
more info
 
cellular response to laminar fluid shear stress ISO
Inferred from Sequence Orthology
more info
 
cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
 
cellular response to leukemia inhibitory factor ISO
Inferred from Sequence Orthology
more info
 
cellular response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to peptide IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to retinoic acid IEP
Inferred from Expression Pattern
more info
PubMed 
epidermal cell differentiation IEA
Inferred from Electronic Annotation
more info
 
epidermal cell differentiation ISO
Inferred from Sequence Orthology
more info
 
epidermis morphogenesis IEA
Inferred from Electronic Annotation
more info
 
epidermis morphogenesis ISO
Inferred from Sequence Orthology
more info
 
fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
negative regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
negative regulation of NF-kappaB transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell migration involved in sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of chemokine (C-X-C motif) ligand 2 production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of chemokine (C-X-C motif) ligand 2 production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of heterotypic cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interleukin-8 biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-8 biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of leukocyte adhesion to arterial endothelial cell IEA
Inferred from Electronic Annotation
more info
 
negative regulation of leukocyte adhesion to arterial endothelial cell ISO
Inferred from Sequence Orthology
more info
 
negative regulation of muscle hyperplasia IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of phosphatidylinositol 3-kinase signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of response to cytokine stimulus IEA
Inferred from Electronic Annotation
more info
 
negative regulation of response to cytokine stimulus ISO
Inferred from Sequence Orthology
more info
 
negative regulation of smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cellular protein metabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cellular protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of core promoter binding IEA
Inferred from Electronic Annotation
more info
 
positive regulation of core promoter binding ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of hemoglobin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of hemoglobin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of nitric oxide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of telomerase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of telomerase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
post-embryonic camera-type eye development IEA
Inferred from Electronic Annotation
more info
 
post-embryonic camera-type eye development ISO
Inferred from Sequence Orthology
more info
 
post-embryonic hemopoiesis IEA
Inferred from Electronic Annotation
more info
 
post-embryonic hemopoiesis ISO
Inferred from Sequence Orthology
more info
 
pri-miRNA transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
pri-miRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
regulation of axon regeneration IEA
Inferred from Electronic Annotation
more info
 
regulation of axon regeneration ISO
Inferred from Sequence Orthology
more info
 
regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
 
regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
regulation of phosphatidylinositol 3-kinase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
response to organic substance ISO
Inferred from Sequence Orthology
more info
 
response to retinoic acid ISO
Inferred from Sequence Orthology
more info
 
stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
 
transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
chromatin IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
nuclear chromatin ISO
Inferred from Sequence Orthology
more info
 
nuclear euchromatin IEA
Inferred from Electronic Annotation
more info
 
nuclear euchromatin ISO
Inferred from Sequence Orthology
more info
 
nuclear transcription factor complex IEA
Inferred from Electronic Annotation
more info
 
nuclear transcription factor complex ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Krueppel-like factor 4
Names
Kruppel-like factor 4 (gut)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053713.1NP_446165.1  Krueppel-like factor 4

    See identical proteins and their annotated locations for NP_446165.1

    Status: PROVISIONAL

    Source sequence(s)
    AF390546
    UniProtKB/TrEMBL
    Q923V7
    Related
    ENSRNOP00000022255.2, ENSRNOT00000022255.3
    Conserved Domains (4) summary
    COG5048
    Location:394477
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:401423
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:399423
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:445470
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005104.4 Reference Rnor_6.0 Primary Assembly

    Range
    72283311..72287669 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000073.1 Alternate Rn_Celera

    Range
    69133658..69138016 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center