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Chrng cholinergic receptor, nicotinic, gamma polypeptide [ Mus musculus (house mouse) ]

Gene ID: 11449, updated on 8-Dec-2022

Summary

Official Symbol
Chrngprovided by MGI
Official Full Name
cholinergic receptor, nicotinic, gamma polypeptideprovided by MGI
Primary source
MGI:MGI:87895
See related
Ensembl:ENSMUSG00000026253 AllianceGenome:MGI:87895
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Acrg; Achr-3
Summary
Enables acetylcholine-gated cation-selective channel activity. Acts upstream of or within regulation of membrane potential. Located in postsynaptic membrane. Part of acetylcholine-gated channel complex. Is expressed in several structures, including diaphragm; embryo mesenchyme; limb bud; skeletal musculature; and tongue. Human ortholog(s) of this gene implicated in multiple pterygium syndrome. Orthologous to human CHRNG (cholinergic receptor nicotinic gamma subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in limb E14.5 (RPKM 16.1), CNS E11.5 (RPKM 1.2) and 1 other tissue See more
Orthologs
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Genomic context

See Chrng in Genome Data Viewer
Location:
1 C5; 1 44.07 cM
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (87133533..87139557)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (87205811..87211835)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene protease, serine 56 Neighboring gene cholinergic receptor, nicotinic, delta polypeptide Neighboring gene eukaryotic translation initiation factor 4E member 2 Neighboring gene predicted gene, 53571 Neighboring gene predicted gene, 26187

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in acetylcholine receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within chemical synaptic transmission IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within chemical synaptic transmission, postsynaptic IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within excitatory postsynaptic potential IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within monoatomic cation transmembrane transport IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in monoatomic cation transport ISO
Inferred from Sequence Orthology
more info
 
involved_in monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in nervous system process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of membrane potential IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in skeletal muscle contraction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of acetylcholine-gated channel complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of acetylcholine-gated channel complex ISO
Inferred from Sequence Orthology
more info
 
part_of acetylcholine-gated channel complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
acetylcholine receptor subunit gamma
Names
nicotinic acetylcholine receptor gamma subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411849.1NP_001398778.1  acetylcholine receptor subunit gamma isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC102611
  2. NM_009604.4NP_033734.3  acetylcholine receptor subunit gamma isoform 1 precursor

    See identical proteins and their annotated locations for NP_033734.3

    Status: VALIDATED

    Source sequence(s)
    AC102611
    Consensus CDS
    CCDS35651.1
    UniProtKB/TrEMBL
    F8VQK4
    Related
    ENSMUSP00000027470.8, ENSMUST00000027470.14
    Conserved Domains (3) summary
    TIGR00860
    Location:23497
    LIC; Cation transporter family protein
    pfam02931
    Location:26241
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:248494
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    87133533..87139557
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529078.3XP_006529141.1  acetylcholine receptor subunit gamma isoform X1

    Conserved Domains (2) summary
    cd19029
    Location:71263
    LGIC_ECD_nAChR_G; extracellular domain of nicotinic acetylcholine receptor subunit gamma (CHRNG)
    pfam02932
    Location:270515
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region