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Wnt2 Wnt family member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 114487, updated on 12-Jan-2022

Summary

Official Symbol
Wnt2provided by RGD
Official Full Name
Wnt family member 2provided by RGD
Primary source
RGD:621346
See related
Ensembl:ENSRNOG00000051905
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Wnt
Summary
Predicted to enable cytokine activity and frizzled binding activity. Involved in lung development and positive regulation of endothelial cell proliferation. Located in cytoplasm. Biomarker of visual epilepsy. Human ortholog(s) of this gene implicated in breast carcinoma; hepatocellular carcinoma; and urinary system cancer. Orthologous to human WNT2 (Wnt family member 2). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Uterus (RPKM 59.5), Lung (RPKM 52.3) and 8 other tissues See more
Orthologs
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Genomic context

See Wnt2 in Genome Data Viewer
Location:
4q21
Exon count:
5
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (46328408..46374673, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (45286845..45332899, complement)

Chromosome 4 - NC_051339.1Genomic Context describing neighboring genes Neighboring gene capping actin protein of muscle Z-line subunit alpha 2 Neighboring gene suppression of tumorigenicity 7 Neighboring gene 60S ribosomal protein L23a-like Neighboring gene ankyrin repeat, SAM and basic leucine zipper domain containing 1 Neighboring gene CF transmembrane conductance regulator

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytokine activity ISO
Inferred from Sequence Orthology
more info
 
enables frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables frizzled binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables receptor ligand activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within atrial cardiac muscle tissue morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cardiac epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
involved_in cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell proliferation in midbrain ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-cell signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to transforming growth factor beta stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within labyrinthine layer blood vessel development ISO
Inferred from Sequence Orthology
more info
 
involved_in lung development IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within lung induction ISO
Inferred from Sequence Orthology
more info
 
involved_in mammary gland epithelium development ISO
Inferred from Sequence Orthology
more info
 
involved_in midbrain dopaminergic neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of epithelial cell proliferation involved in lung morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extrinsic component of external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein Wnt-2
Names
wingless-related MMTV integration site 2
wingless-type MMTV integration site 2
wingless-type MMTV integration site family member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051339.1 Reference mRatBN7.2 Primary Assembly

    Range
    46328408..46374673 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_575397.8XP_575397.1  protein Wnt-2

    See identical proteins and their annotated locations for XP_575397.1

    UniProtKB/TrEMBL
    Q2IBD1
    Related
    ENSRNOP00000071025.1, ENSRNOT00000083039.2
    Conserved Domains (1) summary
    pfam00110
    Location:47349
    wnt; wnt family
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