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Cdk6 cyclin-dependent kinase 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 114483, updated on 10-Oct-2024

Summary

Official Symbol
Cdk6provided by RGD
Official Full Name
cyclin-dependent kinase 6provided by RGD
Primary source
RGD:621121
See related
EnsemblRapid:ENSRNOG00000009258 AllianceGenome:RGD:621121
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables cyclin binding activity. Predicted to be involved in several processes, including negative regulation of cellular senescence; negative regulation of osteoblast differentiation; and regulation of myeloid cell differentiation. Predicted to act upstream of or within several processes, including hemopoiesis; regulation of gene expression; and regulation of hematopoietic stem cell differentiation. Predicted to be located in several cellular components, including centrosome; nucleoplasm; and ruffle. Predicted to be part of cyclin D2-CDK6 complex and mediator complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in high grade glioma; lung non-small cell carcinoma; pancreatic adenocarcinoma; pancreatic ductal carcinoma; and primary autosomal recessive microcephaly 12. Orthologous to human CDK6 (cyclin dependent kinase 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 105.7), Kidney (RPKM 87.0) and 9 other tissues See more
Orthologs
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Genomic context

See Cdk6 in Genome Data Viewer
Location:
4q13
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (31592384..31784732, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (30637650..30829688, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (27781728..27969653, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700109H08 gene like Neighboring gene RNA binding motif protein 48 Neighboring gene family with sequence similarity 133, member B Neighboring gene uncharacterized LOC134486561 Neighboring gene uncharacterized LOC108350668 Neighboring gene heterogeneous nuclear ribonucleoprotein A1, pseudogene 33

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables FBXO family protein binding ISO
Inferred from Sequence Orthology
more info
 
enables cyclin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cyclin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables cyclin binding ISO
Inferred from Sequence Orthology
more info
 
enables cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in DNA damage response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within T cell differentiation in thymus ISO
Inferred from Sequence Orthology
more info
 
involved_in cell dedifferentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in gliogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within hematopoietic stem cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in hemopoiesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cellular senescence ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of monocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of myeloid cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of hematopoietic stem cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to virus ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in type B pancreatic cell development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
part_of cyclin D1-CDK6 complex ISO
Inferred from Sequence Orthology
more info
 
part_of cyclin D2-CDK6 complex ISO
Inferred from Sequence Orthology
more info
 
part_of cyclin D3-CDK6 complex ISO
Inferred from Sequence Orthology
more info
 
part_of cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of cyclin-dependent protein kinase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in ruffle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cyclin-dependent kinase 6
Names
cell division protein kinase 6
NP_001178790.1
XP_006236081.1
XP_006236082.1
XP_006236083.1
XP_038962838.1
XP_063141463.1
XP_063141464.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191861.3NP_001178790.1  cyclin-dependent kinase 6

    See identical proteins and their annotated locations for NP_001178790.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A8I6A5X3, A6K295, F1MA87
    Related
    ENSRNOP00000012597.5, ENSRNOT00000012597.8
    Conserved Domains (1) summary
    cd07862
    Location:11300
    STKc_CDK6; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    31592384..31784732 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006236021.4XP_006236083.1  cyclin-dependent kinase 6 isoform X1

    Conserved Domains (1) summary
    cd07862
    Location:11300
    STKc_CDK6; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 6
  2. XM_006236019.5XP_006236081.1  cyclin-dependent kinase 6 isoform X1

    See identical proteins and their annotated locations for XP_006236081.1

    UniProtKB/TrEMBL
    A0A8I6A5X3, A6K295, F1MA87
    Conserved Domains (1) summary
    cd07862
    Location:11300
    STKc_CDK6; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 6
  3. XM_063285393.1XP_063141463.1  cyclin-dependent kinase 6 isoform X1

    UniProtKB/TrEMBL
    A6K295, F1MA87
  4. XM_006236020.5XP_006236082.1  cyclin-dependent kinase 6 isoform X1

    See identical proteins and their annotated locations for XP_006236082.1

    UniProtKB/TrEMBL
    A0A8I6A5X3, A6K295, F1MA87
    Conserved Domains (1) summary
    cd07862
    Location:11300
    STKc_CDK6; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 6
  5. XM_063285394.1XP_063141464.1  cyclin-dependent kinase 6 isoform X2

  6. XM_039106910.2XP_038962838.1  cyclin-dependent kinase 6 isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:11179
    PKc_like; Protein Kinases, catalytic domain