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Cdk6 cyclin-dependent kinase 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 114483, updated on 18-Apr-2019

Summary

Official Symbol
Cdk6provided by RGD
Official Full Name
cyclin-dependent kinase 6provided by RGD
Primary source
RGD:621121
See related
Ensembl:ENSRNOG00000009258
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
displays amplification and increased expression in the BDII rat model of endometrial cancer [RGD, Feb 2006]
Expression
Biased expression in Thymus (RPKM 105.7), Kidney (RPKM 87.0) and 9 other tissues See more
Orthologs

Genomic context

See Cdk6 in Genome Data Viewer
Location:
4q13
Exon count:
9
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (27781728..27969653, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 4 NC_005103.3 (27685042..27872388, complement)

Chromosome 4 - NC_005103.4Genomic Context describing neighboring genes Neighboring gene similar to EF hand calcium binding domain 1 Neighboring gene RNA binding motif protein 48 Neighboring gene family with sequence similarity 133, member B Neighboring gene uncharacterized LOC102550744 Neighboring gene uncharacterized LOC108350668 Neighboring gene similar to heterogeneous nuclear ribonucleoprotein A2/B1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • ATM Signaling Pathway, organism-specific biosystem (from WikiPathways)
    ATM Signaling Pathway, organism-specific biosystem
    ATM Signaling Pathway
  • Breast cancer, organism-specific biosystem (from KEGG)
    Breast cancer, organism-specific biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
  • Breast cancer, conserved biosystem (from KEGG)
    Breast cancer, conserved biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Cell cycle, organism-specific biosystem (from KEGG)
    Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
  • Cell cycle, organism-specific biosystem (from WikiPathways)
    Cell cycle, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
  • Cell cycle, conserved biosystem (from KEGG)
    Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
  • Cell cycle - G1/S transition, organism-specific biosystem (from KEGG)
    Cell cycle - G1/S transition, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
  • Cell cycle - G1/S transition, conserved biosystem (from KEGG)
    Cell cycle - G1/S transition, conserved biosystemFunctional set; Cellular processes; Cell signaling
  • Cellular Senescence, organism-specific biosystem (from REACTOME)
    Cellular Senescence, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Cellular responses to stress, organism-specific biosystem (from REACTOME)
    Cellular responses to stress, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Chronic myeloid leukemia, organism-specific biosystem (from KEGG)
    Chronic myeloid leukemia, organism-specific biosystemChronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of a pluripotent stem cell. The natural history of CML has a triphasic clinical course comprising of an initial chronic phase (C...
  • Chronic myeloid leukemia, conserved biosystem (from KEGG)
    Chronic myeloid leukemia, conserved biosystemChronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of a pluripotent stem cell. The natural history of CML has a triphasic clinical course comprising of an initial chronic phase (C...
  • Cyclin D associated events in G1, organism-specific biosystem (from REACTOME)
    Cyclin D associated events in G1, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • G1 Phase, organism-specific biosystem (from REACTOME)
    G1 Phase, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • G1 to S cell cycle control, organism-specific biosystem (from WikiPathways)
    G1 to S cell cycle control, organism-specific biosystemIn the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding C...
  • Glioma, organism-specific biosystem (from KEGG)
    Glioma, organism-specific biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
  • Glioma, conserved biosystem (from KEGG)
    Glioma, conserved biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
  • Hepatitis B, organism-specific biosystem (from KEGG)
    Hepatitis B, organism-specific biosystemHepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and...
  • Measles, organism-specific biosystem (from KEGG)
    Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
  • Measles, conserved biosystem (from KEGG)
    Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
  • Melanoma, organism-specific biosystem (from KEGG)
    Melanoma, organism-specific biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
  • Melanoma, conserved biosystem (from KEGG)
    Melanoma, conserved biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
  • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
    MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • MicroRNAs in cancer, conserved biosystem (from KEGG)
    MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • Mitotic G1-G1/S phases, organism-specific biosystem (from REACTOME)
    Mitotic G1-G1/S phases, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Non-small cell lung cancer, organism-specific biosystem (from KEGG)
    Non-small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heter...
  • Non-small cell lung cancer, conserved biosystem (from KEGG)
    Non-small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heter...
  • Oncogene Induced Senescence, organism-specific biosystem (from REACTOME)
    Oncogene Induced Senescence, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Oxidative Stress Induced Senescence, organism-specific biosystem (from REACTOME)
    Oxidative Stress Induced Senescence, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • Pancreatic cancer, organism-specific biosystem (from KEGG)
    Pancreatic cancer, organism-specific biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
  • Pancreatic cancer, conserved biosystem (from KEGG)
    Pancreatic cancer, conserved biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Senescence-Associated Secretory Phenotype (SASP), organism-specific biosystem (from REACTOME)
    Senescence-Associated Secretory Phenotype (SASP), organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Small cell lung cancer, organism-specific biosystem (from KEGG)
    Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
  • Small cell lung cancer, conserved biosystem (from KEGG)
    Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
  • Viral carcinogenesis, organism-specific biosystem (from KEGG)
    Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
  • Viral carcinogenesis, conserved biosystem (from KEGG)
    Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
  • p53 pathway, organism-specific biosystem (from WikiPathways)
    p53 pathway, organism-specific biosystemp53 (also known as protein 53 or tumor protein 53), is a transcription factor which in humans is encoded by the TP53 gene. p53 is important in multicellular organisms, where it regulates the cell cyc...
  • p53 signaling pathway, organism-specific biosystem (from KEGG)
    p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
  • p53 signaling pathway, conserved biosystem (from KEGG)
    p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...

General gene information

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP binding ISO
Inferred from Sequence Orthology
more info
PubMed 
FBXO family protein binding IEA
Inferred from Electronic Annotation
more info
 
FBXO family protein binding ISO
Inferred from Sequence Orthology
more info
PubMed 
cyclin binding IPI
Inferred from Physical Interaction
more info
PubMed 
cyclin binding ISO
Inferred from Sequence Orthology
more info
PubMed 
cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
T cell differentiation in thymus IEA
Inferred from Electronic Annotation
more info
 
T cell differentiation in thymus ISO
Inferred from Sequence Orthology
more info
PubMed 
cell dedifferentiation IEA
Inferred from Electronic Annotation
more info
 
cell dedifferentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
gliogenesis IEA
Inferred from Electronic Annotation
more info
 
gliogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
hematopoietic stem cell differentiation IEA
Inferred from Electronic Annotation
more info
 
hematopoietic stem cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
hemopoiesis ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of cellular senescence IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cellular senescence ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of monocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of monocyte differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of myeloid cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
PubMed 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of erythrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
regulation of erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of gene expression ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of hematopoietic stem cell differentiation IEA
Inferred from Electronic Annotation
more info
 
regulation of hematopoietic stem cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
response to virus IEA
Inferred from Electronic Annotation
more info
 
response to virus ISO
Inferred from Sequence Orthology
more info
PubMed 
type B pancreatic cell development IEA
Inferred from Electronic Annotation
more info
 
type B pancreatic cell development ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
centrosome IEA
Inferred from Electronic Annotation
more info
 
centrosome ISO
Inferred from Sequence Orthology
more info
PubMed 
cyclin D2-CDK6 complex IEA
Inferred from Electronic Annotation
more info
 
cyclin D2-CDK6 complex ISO
Inferred from Sequence Orthology
more info
PubMed 
cyclin-dependent protein kinase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
ruffle IEA
Inferred from Electronic Annotation
more info
 
ruffle ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
cyclin-dependent kinase 6
Names
cell division protein kinase 6
NP_001178790.1
XP_006236081.1
XP_006236082.1
XP_006236083.1
XP_008760901.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191861.1NP_001178790.1  cyclin-dependent kinase 6

    See identical proteins and their annotated locations for NP_001178790.1

    Status: PROVISIONAL

    Source sequence(s)
    AABR07059622, AABR07059623, AABR07059625, AABR07059626
    UniProtKB/TrEMBL
    F1MA87
    Related
    ENSRNOP00000012597.5, ENSRNOT00000012597.6
    Conserved Domains (2) summary
    smart00220
    Location:13300
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07862
    Location:11300
    STKc_CDK6; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 6

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005103.4 Reference Rnor_6.0 Primary Assembly

    Range
    27781728..27969653 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006236021.2XP_006236083.1  cyclin-dependent kinase 6 isoform X1

    See identical proteins and their annotated locations for XP_006236083.1

    UniProtKB/TrEMBL
    F1MA87
    Conserved Domains (2) summary
    smart00220
    Location:13300
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07862
    Location:11300
    STKc_CDK6; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 6
  2. XM_006236019.3XP_006236081.1  cyclin-dependent kinase 6 isoform X1

    See identical proteins and their annotated locations for XP_006236081.1

    UniProtKB/TrEMBL
    F1MA87
    Conserved Domains (2) summary
    smart00220
    Location:13300
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07862
    Location:11300
    STKc_CDK6; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 6
  3. XM_008762679.2XP_008760901.1  cyclin-dependent kinase 6 isoform X1

    See identical proteins and their annotated locations for XP_008760901.1

    UniProtKB/TrEMBL
    F1MA87
    Conserved Domains (2) summary
    smart00220
    Location:13300
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07862
    Location:11300
    STKc_CDK6; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 6
  4. XM_006236020.3XP_006236082.1  cyclin-dependent kinase 6 isoform X1

    See identical proteins and their annotated locations for XP_006236082.1

    UniProtKB/TrEMBL
    F1MA87
    Conserved Domains (2) summary
    smart00220
    Location:13300
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07862
    Location:11300
    STKc_CDK6; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 6

Alternate Rn_Celera

Genomic

  1. AC_000072.1 Alternate Rn_Celera

    Range
    26070823..26248747 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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