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Chrnb2 cholinergic receptor nicotinic beta 2 subunit [ Mus musculus (house mouse) ]

Gene ID: 11444, updated on 17-Jul-2024

Summary

Official Symbol
Chrnb2provided by MGI
Official Full Name
cholinergic receptor nicotinic beta 2 subunitprovided by MGI
Primary source
MGI:MGI:87891
See related
Ensembl:ENSMUSG00000027950 AllianceGenome:MGI:87891
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Acrb2; Acrb-2; [b]2-nAchR; C030030P04Rik
Summary
Enables acetylcholine-gated cation-selective channel activity. Involved in regulation of synaptic vesicle exocytosis. Acts upstream of or within several processes, including learning or memory; nervous system development; and regulation of circadian sleep/wake cycle, sleep. Located in external side of plasma membrane. Is integral component of postsynaptic specialization membrane and integral component of presynaptic membrane. Part of acetylcholine-gated channel complex. Is active in cholinergic synapse and dopaminergic synapse. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study attention deficit hyperactivity disorder; autism spectrum disorder; and autosomal dominant nocturnal frontal lobe epilepsy 3. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy and autosomal dominant nocturnal frontal lobe epilepsy 3. Orthologous to human CHRNB2 (cholinergic receptor nicotinic beta 2 subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in whole brain E14.5 (RPKM 17.9), cerebellum adult (RPKM 14.9) and 8 other tissues See more
Orthologs
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Genomic context

See Chrnb2 in Genome Data Viewer
Location:
3 F1; 3 39.19 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89660755..89671939, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89753448..89764632, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6071 Neighboring gene STARR-positive B cell enhancer ABC_E2081 Neighboring gene phosphomevalonate kinase Neighboring gene potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 Neighboring gene STARR-seq mESC enhancer starr_08246 Neighboring gene STARR-seq mESC enhancer starr_08247 Neighboring gene STARR-seq mESC enhancer starr_08249 Neighboring gene STARR-positive B cell enhancer ABC_E4555 Neighboring gene adenosine deaminase, RNA-specific Neighboring gene RIKEN cDNA 4632404H12 gene Neighboring gene STARR-positive B cell enhancer ABC_E2082 Neighboring gene ubiquitin-conjugating enzyme E2Q family member 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (7)  1 citation

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetylcholine binding ISO
Inferred from Sequence Orthology
more info
 
enables acetylcholine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables acetylcholine receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables acetylcholine-gated monoatomic cation-selective channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables acetylcholine-gated monoatomic cation-selective channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables acetylcholine-gated monoatomic cation-selective channel activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables acetylcholine-gated monoatomic cation-selective channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables acetylcholine-gated monoatomic cation-selective channel activity ISO
Inferred from Sequence Orthology
more info
 
enables extracellular ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to heterocyclic compound binding ISO
Inferred from Sequence Orthology
more info
 
enables heterocyclic compound binding ISO
Inferred from Sequence Orthology
more info
 
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables quaternary ammonium group binding ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within B cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of B cell proliferation IC
Inferred by Curator
more info
PubMed 
acts_upstream_of B cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in acetylcholine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within acetylcholine receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in acetylcholine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within associative learning IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within behavioral response to nicotine IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in behavioral response to nicotine ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within calcium ion transport IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within central nervous system neuron axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within central nervous system projection neuron axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cognition ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within conditioned taste aversion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of dopamine secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lateral geniculate nucleus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in learning ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in membrane depolarization IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within membrane depolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in memory ISO
Inferred from Sequence Orthology
more info
 
involved_in monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of neuronal action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nervous system process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuronal action potential IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of neuronal action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuronal action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within optic nerve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of B cell proliferation IC
Inferred by Curator
more info
PubMed 
acts_upstream_of_or_within positive regulation of B cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of dopamine secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of synaptic transmission, dopaminergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in presynaptic modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in presynaptic modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of circadian sleep/wake cycle, REM sleep IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of circadian sleep/wake cycle, non-REM sleep IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of dopamine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of dopamine secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of membrane potential IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of synapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of synaptic transmission, dopaminergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to acetylcholine ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to cocaine IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to ethanol IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to nicotine IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within response to nicotine IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to nicotine ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within smooth muscle contraction IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within social behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within synaptic transmission involved in micturition IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in synaptic transmission, cholinergic ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within vestibulocochlear nerve development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within visual learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in visual learning ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within visual perception IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of acetylcholine-gated channel complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of acetylcholine-gated channel complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of acetylcholine-gated channel complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cholinergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cholinergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in cholinergic synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in dopaminergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in dopaminergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in plasma membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynaptic specialization membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic specialization membrane ISO
Inferred from Sequence Orthology
more info
 
located_in presynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynaptic membrane IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
neuronal acetylcholine receptor subunit beta-2
Names
acetylcholine receptor beta 2 neural
cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009602.4NP_033732.2  neuronal acetylcholine receptor subunit beta-2 precursor

    See identical proteins and their annotated locations for NP_033732.2

    Status: VALIDATED

    Source sequence(s)
    AK051742, BC065103, BY123599
    Consensus CDS
    CCDS17515.1
    UniProtKB/Swiss-Prot
    Q8BGP7, Q9ERK7
    UniProtKB/TrEMBL
    Q9R291
    Related
    ENSMUSP00000029562.4, ENSMUST00000029562.5
    Conserved Domains (3) summary
    TIGR00860
    Location:29478
    LIC; Cation transporter family protein
    pfam02931
    Location:29234
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:241477
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    89660755..89671939 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162861.1XP_036018754.1  neuronal acetylcholine receptor subunit beta-2 isoform X1

    UniProtKB/TrEMBL
    Q9R291
    Conserved Domains (3) summary
    TIGR00860
    Location:2418
    LIC; Cation transporter family protein
    cd03558
    Location:95109
    LGIC_ECD; Cys-loop [structural motif]
    cl28912
    Location:1174
    LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))
  2. XM_030252389.2XP_030108249.1  neuronal acetylcholine receptor subunit beta-2 isoform X1

    UniProtKB/TrEMBL
    Q9R291
    Conserved Domains (3) summary
    TIGR00860
    Location:2418
    LIC; Cation transporter family protein
    cd03558
    Location:95109
    LGIC_ECD; Cys-loop [structural motif]
    cl28912
    Location:1174
    LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))