igf1 insulin-like growth factor 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: igf1provided by ZNC
Official Full Name: insulin-like growth factor 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-010607-2
See related: Ensembl:ENSDARG00000094132 AllianceGenome:ZFIN:ZDB-GENE-010607-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: IGF-1; IGF-I; IGF-1L; IGF-1a
Summary: Enables insulin-like growth factor receptor binding activity. Acts upstream of or within dorsal/ventral pattern formation; positive regulation of cell population proliferation; and regulation of lipid metabolic process. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including blood plasma; digestive system; eye; female organism; and musculature system. Human ortholog(s) of this gene implicated in several diseases, including acne; artery disease (multiple); diabetes mellitus (multiple); myopia; and neurodegenerative disease (multiple). Orthologous to human IGF1 (insulin like growth factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	4	NC_133179.1 (17897440..17918791)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (17310187..17327012)

Chromosome 4 - NC_133179.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that a group of epithelial cells expressing insulin-like growth factor binding protein 5a (igfbp5a) take up Ca(2+) and proliferate under low Ca(2+) conditions because of activation of insulin like growth factors (IGF) signaling.
Title: Ca(2+) concentration-dependent premature death of igfbp5a(-/-) fish reveals a critical role of IGF signaling in adaptive epithelial growth.
Results suggest that locally derived intra-ovarian IGF1 may have a role in the differentiation and growth of primary follicles in zebrafish ovary.
Title: IGF1 stimulates differentiation of primary follicles and their growth in ovarian explants of zebrafish (Danio rerio) cultured in vitro.
Study demonstrated that IGF-I can stimulate egfr expression in both follicles cell culture and intact follicles promoting oocyte maturation.
Title: Insulin-like growth factor I promotes oocyte maturation through increasing the expression and phosphorylation of epidermal growth factor receptor in the zebrafish ovary.
IGF-I-induced kitlga expression is inhibited by epidermal growth factor, an oocyte-derived paracrine factor in the zebrafish follicle.
Title: Differential regulation of Kit ligand A expression in the ovary by IGF-I via different pathways.
hypoxia causes PGC migration defect by inhibiting IGF signaling through the induction of IGFBP-1
Title: Hypoxia impairs primordial germ cell migration in zebrafish (Danio rerio) embryos.
amphioxus and zebrafish both share a similar regulatory mechanism of IGF gene expression in response to T(3), providing an evidence for the presence of a vertebrate-like TH/IGF signaling pathway in the protochordate amphioxus.
Title: Expression and regulation by thyroid hormone (TH) of zebrafish IGF-I gene and amphioxus IGFl gene with implication of the origin of TH/IGF signaling pathway.
Whereas hypoxia repressed the Igf1 receptor and its downstream Erk1/2 and Akt signaling activities, re-oxygenation restored their activities
Title: Role of IGF signaling in catch-up growth and accelerated temporal development in zebrafish embryos in response to oxygen availability.
zebrafish primordial germ cells intrinsically require IGF signaling for directional migration in vivo
Title: Paracrine insulin-like growth factor signaling influences primordial germ cell migration: in vivo evidence from the zebrafish model.
IGF signalling influences expression of BMP2b, a gene that plays an important role in zebrafish pattern formation
Title: Insulin-like growth factor (IGF) signalling is required for early dorso-anterior development of the zebrafish embryo.
The insulin-like growth factor 1 gene can be differentially transcribed to yield two distinct IGF-1 mRNA transcripts
Title: Insulin-like growth factor signaling in fish.

Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables insulin-like growth factor receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables insulin-like growth factor receptor binding	IPI Inferred from Physical Interaction more info

Process	Evidence Code	Pubs
involved_in cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin-like growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	NAS Non-traceable Author Statement more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: insulin-like growth factor 1

Names: igf1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131825.2 → NP_571900.1 insulin-like growth factor 1 precursor

See identical proteins and their annotated locations for NP_571900.1

Status: PROVISIONAL

Source sequence(s)

BC114262

UniProtKB/TrEMBL

Q29RD0, Q90VV9

Related

ENSDARP00000017449.7, ENSDART00000004717.8

Conserved Domains (1) summary

cd04368
Location:45 → 112

IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...