angptl3 angiopoietin-like 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: angptl3provided by ZNC
Official Full Name: angiopoietin-like 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-010817-3
See related: Ensembl:ENSDARG00000044365 AllianceGenome:ZFIN:ZDB-GENE-010817-3
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb60e11; fb66h02; wu:fb60e11; wu:fb66h02; zgc:111943
Summary: Predicted to enable phospholipase inhibitor activity. Acts upstream of or within hepatocyte proliferation and lipid metabolic process. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in liver; liver primordium; male organism; and yolk syncytial layer. Human ortholog(s) of this gene implicated in familial hypobetalipoproteinemia 2. Orthologous to human ANGPTL3 (angiopoietin like 3). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	6	NC_133181.1 (34860861..34871944, complement)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (32344673..32349151, complement)

Chromosome 6 - NC_133181.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of Angptl3 decreases liver size in developing zebrafish.
Title: Angiopoietin-like 3 regulates hepatocyte proliferation and lipid metabolism in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

fb60e11 (e-PCR)
- UniSTS:187286

fb66h02 (e-PCR), detects polymorphism
- UniSTS:187342

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables enzyme inhibitor activity	IEA Inferred from Electronic Annotation more info
enables phospholipase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood coagulation	IEA Inferred from Electronic Annotation more info
involved_in cholesterol homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hepatocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within liver development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid homeostasis	IEA Inferred from Electronic Annotation more info
involved_in triglyceride homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in triglyceride homeostasis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: angiopoietin-related protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131818.3 → NP_571893.2 angiopoietin-related protein 3 precursor

Status: VALIDATED

Source sequence(s)

EH447322, JBMGRA010000006

UniProtKB/TrEMBL

A0A8N7UZN6, F1QYL5

Related

ENSDARP00000117939.1, ENSDART00000140004.3

Conserved Domains (2) summary

cd00087
Location:248 → 461

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

cl25732
Location:111 → 209

SMC_N; RecF/RecN/SMC N terminal domain