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CGB1 chorionic gonadotropin subunit beta 1 [ Homo sapiens (human) ]

Gene ID: 114335, updated on 23-Nov-2021

Summary

Official Symbol
CGB1provided by HGNC
Official Full Name
chorionic gonadotropin subunit beta 1provided by HGNC
Primary source
HGNC:HGNC:16721
See related
Ensembl:ENSG00000267631 MIM:608823
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The beta subunit of chorionic gonadotropin (CGB) is encoded by six highly homologous and structurally similar genes that are arranged in tandem and inverted pairs on chromosome 19q13.3, and contiguous with the luteinizing hormone beta (LHB) subunit gene. The CGB genes are primarily distinguished by differences in the 5' untranscribed region. This gene was originally thought to be one of the two pseudogenes (CGB1 and CGB2) of CGB subunit, however, detection of CGB1 and CGB2 transcripts in vivo, and their presence on the polysomes, suggested that these transcripts are translated. To date, a protein product corresponding to CGB1 has not been isolated. The deduced sequence of the hypothetical protein of 132 aa does not share any similarity with that of functional CGB subunits (PMID:8954017). However, a 155 aa protein, translated from a different frame, is about the same size, and shares 98% identity with other CGB subunits. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward placenta (RPKM 22.7) See more
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Genomic context

See CGB1 in Genome Data Viewer
Location:
19q13.33
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (49035569..49036895, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (49538826..49540152, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene small NF90 (ILF3) associated RNA G2 Neighboring gene chorionic gonadotropin subunit beta 2 Neighboring gene small NF90 (ILF3) associated RNA G1 Neighboring gene neurotrophin 6 beta (pseudogene)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables hormone activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
choriogonadotropin subunit beta variant 1
Names
chorionic gonadotropin beta subunit 1
chorionic gonadotropin, beta polypeptide 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001382421.1NP_001369350.1  choriogonadotropin subunit beta variant 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC008687
    Related
    ENSP00000472896.2, ENST00000601167.1
    Conserved Domains (1) summary
    smart00068
    Location:11117
    GHB; Glycoprotein hormone beta chain homologues
  2. NM_033377.2NP_203695.2  choriogonadotropin subunit beta variant 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_203695.2

    Status: REVIEWED

    Source sequence(s)
    AC008687
    Consensus CDS
    CCDS12751.2
    UniProtKB/Swiss-Prot
    A6NKQ9
    Related
    ENSP00000301407.6, ENST00000301407.8
    Conserved Domains (1) summary
    smart00068
    Location:23129
    GHB; Glycoprotein hormone beta chain homologues

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    49035569..49036895 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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