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Dok4 docking protein 4 [ Mus musculus (house mouse) ]

Gene ID: 114255, updated on 11-Apr-2024

Summary

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Official Symbol
Dok4provided by MGI
Official Full Name
docking protein 4provided by MGI
Primary source
MGI:MGI:2148865
See related
Ensembl:ENSMUSG00000040631 AllianceGenome:MGI:2148865
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Acts upstream of or within nervous system development; positive regulation of MAPK cascade; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; dorsal root ganglion; heart; retina; and spleen primordium. Orthologous to human DOK4 (docking protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in colon adult (RPKM 63.0), large intestine adult (RPKM 54.8) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Dok4 in Genome Data Viewer
Location:
8 C5; 8 46.93 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (95590456..95602940, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (94863828..94876312, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene cytokine induced apoptosis inhibitor 1 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene coenzyme Q9 Neighboring gene STARR-positive B cell enhancer ABC_E10518 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide C Neighboring gene coiled-coil domain containing 102A Neighboring gene STARR-positive B cell enhancer mm9_chr8:97441323-97441623 Neighboring gene adhesion G protein-coupled receptor G5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Pleckstrin homology and phosphotyrosine-binding domain-dependent membrane association and tyrosine phosphorylation of Dok-4, an inhibitory adapter molecule expressed in epithelial cells. Bedirian A, et al. J Biol Chem, 2004 Apr 30. PMID 14963042
  2. New insights into Dok-4 PTB domain structure and function. Hooker E, et al. Biochem Biophys Res Commun, 2012 Oct 12. PMID 22982678
  3. Binding and inhibition of the ternary complex factor Elk-4/Sap1 by the adapter protein Dok-4. Hooker E, et al. Biochem J, 2017 Apr 19. PMID 28275114
  4. The Calcium Channel Subunit Alpha2delta2 Suppresses Axon Regeneration in the Adult CNS. Tedeschi A, et al. Neuron, 2016 Oct 19. PMID 27720483
  5. Endocardiogenesis in embryoid bodies: novel markers identified by gene expression profiling. Narumiya H, et al. Biochem Biophys Res Commun, 2007 Jun 15. PMID 17462595

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dok-4 can target Elk-4 activity through multiple mechanisms, including binding of the transactivation domain, nuclear exclusion and protein destabilization.
    Title: Binding and inhibition of the ternary complex factor Elk-4/Sap1 by the adapter protein Dok-4.
  2. the current study have explored in more detail the structure and function of the Dok-4 PTB domain.
    Title: New insights into Dok-4 PTB domain structure and function.
  3. Dok-4 is a constitutively membrane-localized adapter molecule that may function as an inhibitor of tyrosine kinase signaling in epithelial cells.
    Title: Pleckstrin homology and phosphotyrosine-binding domain-dependent membrane association and tyrosine phosphorylation of Dok-4, an inhibitory adapter molecule expressed in epithelial cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway IPI
Inferred from Physical Interaction
more info
 PubMed 
acts_upstream_of_or_within nervous system development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
docking protein 4
Names
downstream of tyrosine kinase 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053246.3 → NP_444476.1  docking protein 4

    See identical proteins and their annotated locations for NP_444476.1

    Status: VALIDATED

    Source sequence(s)
    AC129606
    Consensus CDS
    CCDS40443.1
    UniProtKB/Swiss-Prot
    Q3U0X3, Q99KE3
    Related
    ENSMUSP00000043554.8, ENSMUST00000046461.9
    Conserved Domains (2) summary
    cd13164
    Location:133 → 235
    PTB_DOK4_DOK5_DOK6; Downstream of tyrosine kinase 4, 5, and 6 proteins phosphotyrosine-binding domain (PTBi)
    cd14678
    Location:9 → 113
    PH_DOK4_DOK5_DOK6; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 4, 5, and 6 proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    95590456..95602940 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530579.5 → XP_006530642.1  docking protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006530642.1

    UniProtKB/Swiss-Prot
    Q3U0X3, Q99KE3
    Conserved Domains (2) summary
    cd13164
    Location:133 → 235
    PTB_DOK4_DOK5_DOK6; Downstream of tyrosine kinase 4, 5, and 6 proteins phosphotyrosine-binding domain (PTBi)
    cd14678
    Location:9 → 113
    PH_DOK4_DOK5_DOK6; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 4, 5, and 6 proteins

  2. XM_036153721.1 → XP_036009614.1  docking protein 4 isoform X1

    UniProtKB/Swiss-Prot
    Q3U0X3, Q99KE3
    Related
    ENSMUSP00000148355.2, ENSMUST00000212810.2
    Conserved Domains (2) summary
    cd13164
    Location:133 → 235
    PTB_DOK4_DOK5_DOK6; Downstream of tyrosine kinase 4, 5, and 6 proteins phosphotyrosine-binding domain (PTBi)
    cd14678
    Location:9 → 113
    PH_DOK4_DOK5_DOK6; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 4, 5, and 6 proteins

  3. XM_030243242.2 → XP_030099102.1  docking protein 4 isoform X1

    UniProtKB/Swiss-Prot
    Q3U0X3, Q99KE3
    Conserved Domains (2) summary
    cd13164
    Location:133 → 235
    PTB_DOK4_DOK5_DOK6; Downstream of tyrosine kinase 4, 5, and 6 proteins phosphotyrosine-binding domain (PTBi)
    cd14678
    Location:9 → 113
    PH_DOK4_DOK5_DOK6; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 4, 5, and 6 proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99KE3.1 GenPept UniProtKB/Swiss-Prot:Q99KE3

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